An update on Rodgers and Chido, the antigenic determinants of human C4

Giles, C.M.

doi:10.21307/immunohematology-2019-1057

Abstract

Rodgers (Rg) and Chido (Ch) blood groups are antigenic determinants of the fourth component of human complement (C4). Nine determinants have been defined by means of hemagglutination-inhibition (HAI) with polyspecific human antiserums. The association of C4A isotypes with Rg and of C4B isotypes with Ch is strong but not complete. Derived amino acid sequences from the C4d region of selected C4 allotypes of known antigenic expression have provided support for the previously reported complex serologic interrelationships. A structural model for antigenic determinants at four polymorphic sites, incorporating sequential and conformational epitopes, was subsequently proposed. Allotype and Rg/Ch data obtained from donors and patients, many with accompanying families, have augmented the model and revealed no exceptions. The antigenic determinants, therefore, make an important contribution to the complex polymorphism of C4.

References

Harris JP, Tegoli J, Swanson J, Fisher N, Gavin J, Noades J. A nebulous antibody responsible for cross-matching difficulties (Chido). Vox Sang 1967; 12:140–2.10.1111/j.1423-0410.1967.tb03078.x
Search in Google Scholar Back to article
Longster G, Giles CM. A new antibody specificity, anti-Rg^a, reacting with a red cell and serum antigen. Vox Sang 1976;30:175–80.10.1111/j.1423-0410.1976.tb02810.x
Search in Google Scholar Back to article
Middleton J, Crookston MC, Falk JA, et al. Linkage of Chido and HLA. Tissue Antigens 1974;4:366–73.10.1111/j.1399-0039.1974.tb00262.x
Search in Google Scholar Back to article
Giles CM, Gedde-Dahl T Jr, Robson EB, et al. Rg^a (Rodgers) and the HLA region; linkage and associations. Tissue Antigens 1974;8:143–9.10.1111/j.1399-0039.1976.tb00578.x
Search in Google Scholar Back to article
Middleton J, Crookston MC. Chido-substance in plasma. Vox Sang 1972;23:256–61.10.1111/j.1423-0410.1972.tb03459.x
Search in Google Scholar Back to article
Giles CM, Serologically difficult red cell antibodies with special reference to Chido and Rodgers blood groups. In: Human blood groups. Proc 5th Int Convoc Immunol, Buffalo, 1976. Basel: Karger, 1977:268–76.
Search in Google Scholar Back to article
O’Neill GJ, Yang SY, Tegoli J, Berger R, Dupont B. Chido and Rodgers blood groups are distinct antigenic components of human complement C4. Nature 1978;273:668–70.10.1038/273668a0
Search in Google Scholar Back to article
Rittner C, Hauptmann G, Grosse-Wilde H, Grosshans E, Tongio MM, Mayer S. Linkage between HL-A (major histocompatibility complex) and gene(s) controlling the synthesis of the fourth component of complement. In Histocompatibility testing. Copenhagen: Munksgaard, 1975:945–54.
Search in Google Scholar Back to article
Teisberg P, Akesson I, Olaisen B, Gedde-Dahl T Jr, Thorsby E. Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6. Nature 1976;264:253–4.10.1038/264253a0
Search in Google Scholar Back to article
O’Neill GJ, Yang SY, Dupont B. Two HLA-linked loci controlling the fourth component of human complement. Proc Natl Acad Sci (USA) 1978;75:5165–9.10.1073/pnas.75.10.5165
Search in Google Scholar Back to article
Rittner C, Giles CM, Roos MH, Demant P, Mollenhauer E. Genetics of human C4 polymorphism: detection and segregation of rare and duplicated haplotypes. Immunogenetics 1984;19:321–33.10.1007/BF00345405
Search in Google Scholar Back to article
Roos MH, Giles CM, Demant P, Mollenhauer E, Rittner C. Rodgers (Rg) and Chido (Ch) determinants on human C4: characterization of two C4B5 subtypes, one of which contains Rg and Ch determinants. J Immunol 1984; 133:2634–40.10.4049/jimmunol.133.5.2634
Search in Google Scholar Back to article
Giles CM. ‘Partial inhibition’ of anti-Rg and anti-Ch reagents. II. Demonstration of separable antibodies for different determinants. Vox Sang 1985;48:167–73.
Search in Google Scholar Back to article
Giles CM. Three Chido determinants detected on the B5Rg ⁺ allotype of human C4: their expression in Ch-typed donors and families. Hum Immunol 1987;18:111–22.10.1016/0198-8859(87)90009-7
Search in Google Scholar Back to article
Giles CM, Jones JW. A new antigenic determinant for C4 of relatively low frequency. Immunogenetics 1987;26:392–4.10.1007/BF00343713
Search in Google Scholar Back to article
Mauff G, Alper CA, Awdeh Z, et al. Statement on the nomenclature of human C4 allotypes. Immunobiology 1983;164:184–91.10.1016/S0171-2985(83)80009-6
Search in Google Scholar Back to article
Giles CM, Batchelor JR, Dodi IA, et al. C4 and HLA haplotypes associated with partial inhibition of anti-Rg and anti-Ch. J Immunogenet 1984;11:305–17.10.1111/j.1744-313X.1984.tb00817.x
Search in Google Scholar Back to article
Giles CM, Hoffman M, Moulds M, Harris M, Dalmasso A. Alloanti-Chido in a Ch-positive patient. Vox Sang 1987;52:129–33.10.1111/j.1423-0410.1987.tb03008.x3604158
Search in Google Scholar Back to article
Giles CM, Swanson JL. Anti-C4 in the serum of a transfused C4-deficient patient with systemic lupus erythematosus. Vox Sang 1984;46:291–9.10.1111/j.1423-0410.1984.tb00089.x6730425
Search in Google Scholar Back to article
Giles CM. Antigenic determinants of human C4, Rodgers and Chido. Exp Clin Immunogenet 1988;5:99–114.
Search in Google Scholar Back to article
Tilley CA, Romans DG, Crookston MC. Localisation of Chido and Rodgers determinants to the C4d fragment of human C4. Nature 1978;276:713–5.10.1038/276713a083538
Search in Google Scholar Back to article
Giles CM. ‘Partial inhibition’ of anti-Rg and anti-Ch reagents. I. Assessment for Rg/Ch typing by inhibition. Vox Sang 1985;48:160–6.
Search in Google Scholar Back to article
Roos MH, Mollenhauer E, Demant P. Rittner C. A molecular basis for the two locus model of human complement component C4. Nature 1982;298:854–6.10.1038/298854a06180321
Search in Google Scholar Back to article
Giles CM, Fielder AHL, Lord DK, Robson T, O’Neill GJ. Two monoclonal anti-C4d reagents react with epitopes closely related to Rg:1 and Ch:1. Immunogenetics 1987;26:309–12.10.1007/BF003465282443448
Search in Google Scholar Back to article
Sklarin PM, Awdeh ZL, Alper CA. An immunoblotting technique for direct visualization of Chido and Rodgers reactivity on C4 variants after electrophoresis. Vox Sang 1988;54:43–6.10.1111/j.1423-0410.1988.tb01611.x2450426
Search in Google Scholar Back to article
Hauptmann G, Goetz J, Uring-Lambert B, Grosshans E. Complement deficiencies 2. The fourth component. In: Progr Allergy. Karger, Basel 1986;39:232–49.
Search in Google Scholar Back to article
Giles CM, Walport MJ, David J, Darke C. Expression of MHC class I determinants on erythrocytes of SLE patients. Clin Exp Immunol 1987;69:368–74.
Search in Google Scholar Back to article
Giles CM, Uring-Lambert B, GoetzJ, et al. Antigenic determinants expressed by human C4 allotypes; a study of 325 families provides evidence for the structural antigenic model. Immunogenetics 1988;27:442–8.10.1007/BF003644312453461
Search in Google Scholar Back to article
Yu CY, Belt KT, Giles CM, Campbell RD, Porter RR. Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity. EMBO J 1986;5:2873–81.10.1002/j.1460-2075.1986.tb04582.x11672372431902
Search in Google Scholar Back to article
Belt KT, Yu CY, Carroll MC, Porter, RR. Polymorphism of human complement component C4. Immunogenetics 1985;21:173–80.10.1007/BF003648693838531
Search in Google Scholar Back to article
Yu CY, Campbell RD, Porter RR. A structural model for the location of the Rodgers and the Chido antigenic determinants and their correlation with the human complement component C4A/C4B isotypes. Immunogenetics 1988;27:399–405.10.1007/BF003644252453459
Search in Google Scholar Back to article
Schendel DJ, Wank R, O’Neill GJ. C4 phenotypic variation suggests an unusual class III gene organization. Vox Sang 1985;48:110–15.10.1111/j.1423-0410.1985.tb00154.x3878038
Search in Google Scholar Back to article
Giles CM, Tokunaga K, Zhang WJ, Tanaka H, Endoh N, Juji T. The antigenic determinants, Rg/Ch/WH, expressed by Japanese C4 allotypes. J Immunogenet 1988 (in press).10.1111/j.1744-313X.1988.tb00430.x
Search in Google Scholar Back to article
Carroll MC, Alpher CA. Polymorphism and molecular genetics of human C4. Br Med Bull 1987;43:50–65.10.1093/oxfordjournals.bmb.a0721763315101
Search in Google Scholar Back to article
Porter RR. Complement polymorphism, the major histocompatibility complex and associated diseases: a speculation. Mol Biol Med 1983;1:161–8.
Search in Google Scholar Back to article
Mevag B, Olaisen B, Teisbeig P. Electrophoretic polymorphism of human C4 is due to charge differences in the α-chain, presumably in the C4d fragment. Scand J Immunol 1981;14:303–7.10.1111/j.1365-3083.1981.tb00568.x7330601
Search in Google Scholar Back to article
Dodds AW; Law SKA, Porter RR. The purification and properties of some less common allotypes of the fourth component of human complement. Immunogenetics 1986;24:279–85.10.1007/BF003955322430883
Search in Google Scholar Back to article

An update on Rodgers and Chido, the antigenic determinants of human C4

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