Incidence of Rodgers-negative individuals in systemic lupus erythematosus patients

Moulds, J.M.

doi:10.21307/immunohematology-2019-1051

Abstract

Early reports of anti-Rodgers (anti-Rg) noted that there was an increased number of the HLA-B8 phenotype among this group. This HLA type has recently been linked to a C4A (Rg) gene deletion found with increased frequency among systemic lupus erythematosus (SLE) patients. Healthy controls (n=176) and SLE patients (n=102) were studied for their HLA haplotype and C4 allotype as well as their Rg phenotype Six of 53 white and 3 of 49 black SLE patients were C44-null and Rodgers-negative, a significant difference from controls (p = .002). A retrospective study of patients who produced anti-Rg showed that one third had symptoms often associated with SLE but none had SLE as a primary diagnosis.

References

Harris JP, Tegoli J, Swanson J, Fisher N, Gavin J, Noades J. A nebulous antibody responsible for crossmatching difficulties (Chido). Vox Sang 1967;12:140–2.10.1111/j.1423-0410.1967.tb03078.x6016836
Search in Google Scholar Back to article
Longster G, Giles CM. A new antibody specificity, anti-Rg^a, reacting with a red cell and serum antigen. Vox Sang 1976; 30:175–80.10.1111/j.1423-0410.1976.tb02810.x1251581
Search in Google Scholar Back to article
Giles CM, Gedde-Dahl T, Jr, Robson EB, et al. Rg^a (Rodgers) and the HLA region: linkage and associations. Tissue Antigens 1976;8:143–9.10.1111/j.1399-0039.1976.tb00578.x
Search in Google Scholar Back to article
O’Neill GJ, Yang SY, Tegoli J, Berger R, Dupont B. Chido and Rodgers blood groups are distinct antigenic components of human complement C4. Nature 1978;273:668–70.10.1038/273668a078453
Search in Google Scholar Back to article
Yu CY, Campbell RD, Porter RR. A structural model for the location of the Rodgers and the Chido antigenic determinants and their correlation with the human complement component C4A/C4B isotypes. Immunogenetics 1988;27:399–405.10.1007/BF003644252453459
Search in Google Scholar Back to article
Giles CM, Uring-Lambert B, Goetz J, et al. Antigenic determinants expressed by human C4 allotypes; a study of 325 families provides evidence for the structural antigenic model. Immunogenetics 1988;27:442–8.10.1007/BF003644312453461
Search in Google Scholar Back to article
Carroll MC, Palsdotirr A, Belt KT, Porter RR. Deletion of complement C4 and 21-hydroxylase genes in the HLA class III region. EMBOJ 1985;4:2547–52.10.1002/j.1460-2075.1985.tb03969.x5545422996881
Search in Google Scholar Back to article
Fielder AHL, Walport MJ, Batchelor JR, et al. Family study of the major histocompatibility complex in a patient with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility. Br J Med 1983; 286:425–8.10.1136/bmj.286.6363.42515467686401549
Search in Google Scholar Back to article
9- Reveille J, Arnett FC, Wilson RW, Bias WB, McLean RH. Null alleles of the fourth component of complement and HLA haplotypes in familiar systemic lupus erythematosus. Immunogenetics 1985;21:299–311.10.1007/BF004307963873410
Search in Google Scholar Back to article
Dunckley H, Gatenby PA, Hawkins B, Naito S, Serjeantson SW. Deficiency of C4A is a genetic determinant of systemic lupus erythematosus in three ethnic groups. J Immunogenet 1987; 14:209–18.10.1111/j.1744-313X.1987.tb00383.x
Search in Google Scholar Back to article
Wilson WA, Perez MC, Armatis PE. Partial C4A deficiency is associated with susceptibility to systemic lupus erythematosus in black Americans. Arthritis Rheum 1988;31:1171–5.10.1002/art.1780310913
Search in Google Scholar Back to article
Kemp ME, Atkinson JP, Skanes VM, Levine RP, Chaplin DD. Deletion of C4A genes in patients with systemic lupus erythematosus. Arthritis Rheum 1987;30:1015–22.10.1002/art.1780300908
Search in Google Scholar Back to article
Goldstein R, Arnett FC, McLean RH, Bias WB, Duvic M. Molecular heterogeneity of complement component C4 “null” and 21-hydroxylase genes in systemic lupus erythematosus. Arthritis Rheum 1988;3L736–44.10.1002/art.1780310606
Search in Google Scholar Back to article
Olsen ML, Goldstein R, Arnett FC, Duvic M, Pollack M, Reveille J. C4A gene deletion and HLA associations in black Americans with systemic lupus erythematosus. Immunogenetics 1989; 30:27–33.10.1007/BF02421466
Search in Google Scholar Back to article
Bias WB, Hsu SH, Pollard MK, et al. HLA-DR characterization of a Chippewa Indian subpopulation with high prevalence of rheumatoid arthritis. Hum Immunol 1981;2:155–63.10.1016/0198-8859(81)90062-8
Search in Google Scholar Back to article
Middleton J, Crookston MC. Chido substance in plasma. Vox Sang 1972;23:256–61.10.1111/j.1423-0410.1972.tb03459.x
Search in Google Scholar Back to article
Mauff G, Alper CA, Awdeh ZL, et al. Statement on the nomenclature of human C4 allotypes. Immunobiology 1983; 164:184–91.10.1016/S0171-2985(83)80009-6
Search in Google Scholar Back to article
Sim E, Cross SJ. Phenotyping of human complement component C4, a class III HLA-antigen. Biochem J 1986;239:763–7.10.1042/bj239076311473523103606
Search in Google Scholar Back to article
Budowle B, Roseman JM, Go RCP, Louv W, Barger BO, Acton RT. Phenotypes of the fourth complement component (C4) in black Americans from the southeastern United States. J Immunogenet 1983;10:199–204.10.1111/j.1744-313X.1983.tb00795.x
Search in Google Scholar Back to article
Howard PF, Hochberg MC, Bias WB, Arnett FC, McLean RH. Relationship beween C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasians and black Americans. Am J Med l986;8l:I87-93.
Search in Google Scholar Back to article
James J, Stiles P, Boyce F, Wright J. The HLA type of Rg(a-) individuals. Vox Sang 1976;30:214–6.10.1111/j.1423-0410.1976.tb02817.x1251587
Search in Google Scholar Back to article

Incidence of Rodgers-negative individuals in systemic lupus erythematosus patients

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