Autoanti-C in a patient with primary sclerosing cholangitis and autoimmune hemolytic anemia: a rare presentation

M. Bajpai; A. Maheshwari; S. Gupta; C. Bihari

doi:10.21307/immunohematology-2019-054

Autoanti-C in a patient with primary sclerosing cholangitis and autoimmune hemolytic anemia: a rare presentation

Immunohematology

Volume 32 (2016): Issue 3 (September 2016)

By: M. Bajpai, A. Maheshwari, S. Gupta and C. Bihari

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Abstract

Primary sclerosing cholangitis (PSC) is rarely associated with autoimmune hemolytic anemia (AIHA), and the presence of specific autoantibodies has not been reported previously. We present a unique case report of PSC associated with AIHA implicating autoanti-C. A 17-year-old girl was admitted to our hospital with PSC along with AIHA. Her blood sample demonstrated a positive direct antiglobulin test and a positive autocontrol in the antihuman globulin phase, confirming the patient had warm-reactive AIHA. Further testing showed the possibility of anti-C. The patient’s Rh phenotype was C+D+E–c– e+. Further testing with select cells, serial alloadsorption, and an elution confirmed anti-C specificity. The patient was transfused with two C–, crossmatch-compatible packed red blood cell units. The patient’s hemoglobin level and general condition showed improvement. This unique case report shows PSC associated with AIHA caused by autoanti-C. Usually, warm AIHA presents with a panreactive pattern, and it is difficult to find compatible blood. In this rare case, we could determine the specific antibody; efforts should always be made in cases of AIHA to identify the specificity of autoantibody. Immunohematology2016;32:104–107.

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Articles in this issue

DOI: https://doi.org/10.21307/immunohematology-2019-054 | Journal eISSN: 1930-3955 | Journal ISSN: 0894-203X

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Language: English

Page range: 104 - 107

Published on: Oct 9, 2019

Published by: American National Red Cross

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

autoimmune hemolytic anemia,

primary sclerosing cholangitis,

Related subjects:

© 2019 M. Bajpai, A. Maheshwari, S. Gupta, C. Bihari, published by American National Red Cross
This work is licensed under the Creative Commons License.

Volume 32 (2016): Issue 3 (September 2016)