Anti-Vel alloimmunization and severe hemolytic disease of the fetus and newborn

Moise, K.J.; Morales, Y.; Bertholf, M.F.; Rossmann, S.N.; Bai, Y.

doi:10.21307/immunohematology-2019-021

Abstract

Only rare cases of anti-Vel–associated mild-to-moderate hemolytic disease of the fetus and newborn have been previously reported. No case of fetal anemia requiring prenatal therapy has been noted to date. We report such a case recently encountered at our Fetal Center. Strategies are discussed for managing pregnancy complicated with alloimmunization to an antibody to a high-prevalence antigen, including sources of red blood cells for intrauterine transfusions. Immunohematology2017;33:152–154.

References

Sussman LN, Miller EB. [New blood factor: Vel.] Rev Hematol 1952;7:368–71.
Search in Google Scholar Back to article
Sussman LN, Pretshold H. The Vel blood group system. Haematologia (Budap) 1972;6:129–33.
Search in Google Scholar Back to article
Drachmann O, Lundsgaard A. Prenatal assessment of blood group antibodies against “public” antigens: an example of anti-Ve (Vel) in pregnancy. Scand J Haematol 1970;7:37–42.10.1111/j.1600-0609.1970.tb01866.x
Search in Google Scholar Back to article
Williams CK, Williams B, Pearson J, Steane SM, Steane EA. An example of anti-Vel causing mild haemolytic disease of the newborn. Transfusion 1985;25:462.
Search in Google Scholar Back to article
Stiller RJ, Lardas O, Haynes de Regt R. Vel isoimmunization in pregnancy. Am J Obstet Gynecol 1990;162:1071–2.10.1016/0002-9378(90)91319-8
Search in Google Scholar Back to article
Le Masne A, Vachée A, Horbey C, et al. [Severe form of neonatal hemolytic disease by anti-Vel allo-immunization.] Arch Fr Pediatr 1992;49:899–901.
Search in Google Scholar Back to article
van Gammeren AJ, Overbeeke MA, Idema RN, van Beek RH, Ten Kate-Booij MJ, Ermens AA. Haemolytic disease of the newborn because of rare anti-Vel. Transfus Med 2008;18:197–8.10.1111/j.1365-3148.2008.00863.x18598283
Search in Google Scholar Back to article
Mari G, Deter RL, Carpenter RL, et al. Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization: Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med 2000;342:9–14.10.1056/NEJM20000106342010210620643
Search in Google Scholar Back to article
Toivanen P, Hirvonen T. Fetal development of red cell antigens K, k, Lu^a, Lu^b, Fy^a, Fy^b, Vel and Xg^a. Scand J Haematol 1969;6:49–55.10.1111/j.1600-0609.1969.tb01803.x5804712
Search in Google Scholar Back to article
Linz WJ, Fueger JT, Allen S, Johnson ST. Role for serial prenatal anti-Vel quantitative serologic monitoring with 2-ME serum treatment during pregnancy: case report. Immunohematology 2010;26:8–10.10.21307/immunohematology-2019-194
Search in Google Scholar Back to article
Gonsoulin WJ, Moise KJ Jr, Milam JD, Sala JD, Weber VW, Carpenter RJ Jr. Serial maternal blood donations for intrauterine transfusion. Obstet Gynecol 1990;75:158–62.
Search in Google Scholar Back to article

Anti-Vel alloimmunization and severe hemolytic disease of the fetus and newborn

Abstract

Paradigm

My account