Baseline characteristics of male pilots included in the study
| Characteristics | Invasive cases only (n=51) | Invasive + in situ cases (n=114) | Controls (n=102) |
|---|---|---|---|
| Age (in years) at diagnosis, mean (SD) | 47 (10.1) | 49 (11.3) | 48.6 (11.3) |
| Age group, n (%) | |||
| <50 | 30 (59) | 57 (50) | 60 (59) |
| 50+ | 21 (41) | 57 (50) | 42 (41) |
| State of residence, n (%) | |||
| QLD | 19 (37) | 45 (40) | 29 (28) |
| NSW | 12 (24) | 27 (24) | 33 (32) |
| VIC | 10 (20) | 20 (18) | 15 (15) |
| Other States | 10 (20) | 22 (19) | 25 (25) |
| Total flying hours, median (IQR) | 6108 (1900-14200) | 6900 (2215-15060) | 7500 (2725-14150) |
| Hours flown in last 6 months, median (IQR) | 200 (54-350) | 200 (70-328) | 206 (80-323) |
Association between flying hours and melanoma risk among class 1 male pilots
| Total flying hours | Invasive cases only OR (95% CI) (n=51) | Invasive + in situ cases OR (95% CI) (n=114) |
|---|---|---|
| Crude analyses | ||
| Total flying hours (per 1000hrs)1 | 0.99 (0.94-1.04) | 1.00 (0.96-1.04) |
| Total flying hours (Tertile groups [median, range])2 | ||
| T1 [1680 (5, 4500)] | Reference | Reference |
| T2 [7500 (4800, 12378)] | 0.94 (0.42-2.13) | 0.88 (0.46-1.69) |
| T3 [16490 (12470, 28000)] | 0.89 (0.39-2.03) | 0.90 (0.47-1.73) |
| Adjusted analyses3 | ||
| Total flying hours (per 1000hrs)1 | 1.00 (0.94-1.06) | 1.00 (.95-1.04) |
| Total flying hours (Tertile groups) | ||
| T1 | Reference | Reference |
| T2 | 1.08 (0.45-2.57) | 0.85 (0.43-1.67) |
| T3 | 1.18 (0.44-3.15) | 0.85 (0.40-1.79) |
Association between flying hours and melanoma risk among class 1 male pilots ages less than 50 years at time of diagnosis
| Total flying hours | Invasive cases only OR (95% CI) (n=30) | Invasive + in situ cases OR (95% CI) (n=57) |
|---|---|---|
| Total flying hours (per 1000hrs)1,2 | 0.93 (0.84-1.02) | 0.94 (0.86-1.02) |
| Total flying hours (Tertile groups [median, range])2,3 | ||
| T1 [893 (5, 3100)] | Reference | Reference |
| T2 [5000 (3200, 9800)] | 1.04 (0.38-2.89) | 1.12 (0.46-2.73) |
| T3 [12985 (10060, 20561)] | 0.37 (0.09-1.36) | 0.42 (0.14-1.28) |
Association between flying hours and melanoma risk among class 1 male pilots diagnosed with melanoma in 2011-2012
| Total flying hours | Year of Diagnosis 2011-2012 | |
|---|---|---|
| Invasive cases only OR (95% CI) (n=22) | Invasive + in situ cases OR (95% CI) (n=45) | |
| Hours flown in last 6 months (per 50hrs)1,2 | 0.85 (0.68-1.05) | 0.98 (0.85-1.13) |
| Hours flown in last 6 months (Tertile groups [Tertile groups])2,3 | ||
| T1 [0.48 (0, 114)] | Reference | Reference |
| T2 [200 (120, 270)] | 0.45 (0.11-1.86) | 0.76 (0.26-2.24) |
| T3 [350 (300-690)] | 0.39 (0.09-1.69) | 0.66 (0.22-2.05) |
Association between flying hours and melanoma risk among class 1 male pilots diagnosed with melanoma on head and neck and upper limbs
| Total flying hours | Head & Neck & Upper Limb | |
|---|---|---|
| Invasive cases only OR (95% CI) (n=13) | Invasive + in situ cases OR (95% CI) (n=38) | |
| Total flying hours (per 1000hrs)1,2 | 1.01 (0.91-1.11) | 0.99 (0.93-1.05) |
| Total flying hours (Tertile groups)2 | ||
| T1 | Reference | Reference |
| T2 | 0.61 (0.13-2.83) | 0.85 (0.33-2.18) |
| T3 | 0.99 (0.20-4.91) | 0.81 (0.29-2.20) |