Table 1.
Clinical features noted in patients with Anti-NMDAR receptor encephalitis
| Focal neurological signs | Weakness in limbs, seizures, altered behaviour, memory loss, confusion |
| Psychiatric signs | Auditory, visual and olfactory hallucinations; irritability, agitation, aggression and violent behaviour; catatonia |
| Autonomic instability | Fever, tachycardia/bradycardia, hypotension/hypertension, hypoventilation |
Table 2.
Clinical presentations, treatments and outcome of cases seen at our hospital
| Case | Symptoms | Treatment | Adjunct therapies | Complications | Outcomes |
|---|---|---|---|---|---|
| F, 25, A | Aphasia, posturing (rigid), myoclonus jerks, tonic-clonic seizures, opsoclonus, decreased level of consciousness, respiratory difficulties, loss of tone, agitation, aggression | Bilateral Oopherectomy | ECT, Methylprednisolone, IVIG, Rituximab, Tetrabenzene, Quetiapine, Haloperidol, Olanzapine, Ketamine and Cyclophosphamide | Intubation, ventilator associated pneumonia, bacteremia, status epilepticus, febrile neutropenia | Complex care rehab, discharged home |
| F, 22, B | Confusion, hallucinations, global aphasia, agnosia, prosopagnosia, memory deficits, posturing, myoclonus and seizures Behavioural issues like cursing, spitting, yelling, agitation and aggression | Bilateral Oopherectomy | AEDs, Acyclovir, IVIG, plasmapheresis, methylprednisolone | Manic symptoms, psychosis (Psychiatry consulted for unresolved mania) | Repatriation, cognitive rehab, discharged home |
| F, 30, C | Brocca’s aphasia progressed to global aphasia, parasthesia in arms, generalized seizures, hallucinations, sensitivity to light and noise, agnosia, prosopagnosia, falling spells and wandering | Right Oopherectomy RRR | Methylprednisolone, IVIG | UTI, allergic reaction to methylprednisolon e (Psychiatry consulted for unresolved catatonia) | Cognitive rehab, discharged home |
Save the Date!
2019 ANNA National Conference
17-18 October 2019
Wellington New Zealand
The 2019 ANNA National Conference will be an action-packed two days of professional development and networking at the Intercontinental Hotel in Wellington, New Zealand!
Block out Thursday 17 and Friday 18 October, 2019 in your calendar now and stay tuned for more information about what is shaping up to be a fantastic National Conference
We look forward to seeing you there
