Have a personal or library account? Click to login
Multi-faceted function of vitamin K with particular consideration of vitamin K2 – literature review Cover

Multi-faceted function of vitamin K with particular consideration of vitamin K2 – literature review

Open Access
|Mar 2020

References

  1. 1. Kosińska J, Billing-Marczak K, Krotkiewski M. Nowopoznana rola witaminy K w patogenezie chorób cywilizacyjnych. Med Rodz 2008;2:48-60.
  2. 2. Ostrowicz A. Rola i znaczenie witaminy K w organizmie człowieka. http://treepharma.pl/wp-content/uploads/2016/02/Rola-i-znaczenie-Witaminy-K-w-organizmie.pdf (12.03.2018).
  3. 3. Solgar. Witamina K. https://solgar.pl/leksykon/witamina-k2 (12.03.2018).
  4. 4. Thijssen HH, Vervoort LM, Schurgers LJ, Shearer MJ. Menadione is a metabolite of oral vitamin K. Br J Nutr 2006;95(2):260-6.10.1079/BJN20051630
  5. 5. Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, et al. Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC). J Nutr 2017;147(5):888-95.10.3945/jn.117.249375
  6. 6. van Ballegooijen AJ, Cepelis A, Visser M, Brouwer IA, van Schoor NM, Beu-lens JW. Joint association of low vitamin D and vitamin K status with blood pressure and hypertension. Hypertension 2017;69(6):1165-72.10.1161/HYPERTENSIONAHA.116.08869
  7. 7. Garcia AA, Reitsma PH. VKORC1 and the vitamin K cycle. Vitam Horm 2008;78:23-33.10.1016/S0083-6729(07)00002-7
  8. 8. Ciurus T, Lelonek M. Znaczenie polimorfizmów genów VKORC1 oraz CYP2C9 dla leczenia przeciwzakrzepowego doustnymi pochodnymi kumaryny – przegląd doniesień. Folia Cardiologica Excerpta 2012;7(4):189-93.
  9. 9. Owen RP, Gong L, Sagreiya H, Klein TE, Altman RB. VKORC1 pharmacog-enomics summary. Pharmacogenet Genomics 2010;20(10):642-4.10.1097/FPC.0b013e32833433b6308604319940803
  10. 10. Tsugawa N, Uenishi K, Ishida H, Minekami T, Doi A, Koike S, et al. A novel method based on curvature analysis for estimating the dietary vitamin K requirement in adolescents. Clin Nutr 2012;31(2):255-60.10.1016/j.clnu.2011.10.00622078785
  11. 11. Lombardi G, Perego S, Luzi L, Banfi G. A four-season molecule: osteocalcin. Updates in its physiological roles. Endocrine 2015;48(2):394-404.10.1007/s12020-014-0401-025158976
  12. 12. Centi AJ, Booth SL, Gundberg CM, Saltzman E, Nicklas B, Shea MK. Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women. Endocrine 2015;50(3):627-32.10.1007/s12020-015-0618-6464341425963022
  13. 13. Atkins GJ, Welldon KJ, Wijenayaka AR, Bonewald LF, Findlay DM. Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by γ-carboxylation-dependent and -independent mechanisms. Am J Physiol Cell Physiol 2009;297(6):C1358-67.10.1152/ajpcell.00216.200919675304
  14. 14. Palermo A, Tuccinardi D, D’Onofrio L, Watanabe M, Maggi D, Maurizi AR, et al. Vitamin K and osteoporosis: Myth or reality? Metabolism 2017;70:57-71.
  15. 15. Ryan-Harshman M, Aldoori W. Bone health. New role for vitamin K? Can Fam Physician 2004;50:993-7.
  16. 16. Finnes TE, Lofthus CM, Meyer HE, Søgaard AJ, Tell GS, Apalset EM, et al. A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study. Osteoporos Int 2016;27(4):1645-52.10.1007/s00198-015-3435-026630974
  17. 17. Fang Y, Hu C, Tao X, Wan Y, Tao F. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials. J Bone Miner Metab 2012;30(1):60-8.10.1007/s00774-011-0287-321674202
  18. 18. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int 2015;26(3):1175-86.10.1007/s00198-014-2989-625516361
  19. 19. Hao G, Zhang B, Gu M, Chen C, Zhang Q, Zhang G, et al. Vitamin K intake and the risk of fractures: A meta-analysis. Medicine (Baltimore) 2017;96(17):e6725.10.1097/MD.0000000000006725541325428445289
  20. 20. Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S. Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J Mol Endocrinol 2007;39(4):239-47.10.1677/JME-07-004817909264
  21. 21. Ebina K, Noguchi T, Hirao M, Kaneshiro S, Tsukamoto Y, Yoshikawa H. Comparison of the effects of 12 months of monthly minodronate monotherapy and monthly minodronate combination therapy with vitamin K2 or eldecalcitol in patients with primary osteoporosis. J Bone Miner Metab 2016;34(3):243-50.10.1007/s00774-015-0710-226303222
  22. 22. Iwamoto J, Takeda T, Sato Y. Prevention and treatment of corticosteroid--induced osteoporosis. Yonsei Med J 2005;46(4):456-63.10.3349/ymj.2005.46.4.456281582816127768
  23. 23. Sanguineti R, Monacelli F, Parodi A, Furfaro AL, Borghi R, Pacini D, et al. Vitamins D3 and K2 may partially counterbalance the detrimental effects of pentosidine in ex vivo human osteoblasts. J Biol Regul Homeost Agents 2016;30(3):713-26.
  24. 24. Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S. Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. J Biol Chem 2006;281(25):16927-34.10.1074/jbc.M60089620016606623
  25. 25. Zhang Y, Weng S, Yin J, Ding H, Zhang C, Gao Y. Vitamin K2 promotes mesenchymal stem cell differentiation by inhibiting miR-133a expression. Mol Med Rep 2017;15(5):2473-80.10.3892/mmr.2017.6308542886728447758
  26. 26. Sung B, Oyajobi B, Aggarwal BB. Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling. Mol Cancer Ther 2012;11(2):350-9.10.1158/1535-7163.MCT-11-0731327766322090419
  27. 27. Neogi T, Booth SL, Zhang YQ, Jacques PF, Terkeltaub R, Aliabadi P, et al. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum 2006;54(4):1255-61.10.1002/art.2173516572460
  28. 28. Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh CK, et al. The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study. Osteoarthritis Cartilage 2015;23(3):370-8.10.1016/j.joca.2014.12.008433950725528106
  29. 29. Rafael MS, Cavaco S, Viegas CS, Santos S, Ramos A, Willems BA, et al. Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status. Mol Nutr Food Res 2014;58(8):1636-46.10.1002/mnfr.20130094124867294
  30. 30. Han JM, Jo AN, Lee SM, Bae HS, Jun DW, Cho YK, et al. Associations between intakes of individual nutrients or whole food groups and non-alcoholic fatty liver disease among Korean adults. J Gastroenterol Hepatol 2014;29(6):1265-72.10.1111/jgh.1252024955455
  31. 31. Mizuta T, Ozaki I, Eguchi Y, Yasutake T, Kawazoe S, Fujimoto K, et al. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer 2006;106(4):867-72.10.1002/cncr.2166716400650
  32. 32. Enokimura N, Shiraki K, Kawakita T, Saitou Y, Inoue H, Okano H, et al. Vitamin K analog (compound 5) induces apoptosis in human hepatocellular carcinoma independent of the caspase pathway. Anticancer Drugs 2005;16(8):837-44.10.1097/01.cad.0000175583.78574.d716096431
  33. 33. Ide Y, Zhang H, Hamajima H, Kawaguchi Y, Eguchi Y, Mizuta T, et al. Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. Oncol Rep 2009;22(3):599-604.
  34. 34. Azuma K, Urano T, Ouchi Y, Inoue S. Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor. Endocr J 2009;56(7):843-9.10.1507/endocrj.K09E-108
  35. 35. Ha TY, Hwang S, Hong HN, Choi YI, Yoon SY, Won YJ, et al. Synergistic effect of sorafenib and vitamin K on suppression of hepato-cellular carcinoma cell migration and metastasis. Anticancer Res 2015;35(4):1985-95.
  36. 36. Wei G, Wang M, Hyslop T, Wang Z, Carr BI. Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo. Int J Cancer 2010;127(12):2949-58.10.1002/ijc.25498295518521351273
  37. 37. Yoshiji H, Noguchi R, Toyohara M, Ikenaka Y, Kitade M, Kaji K, et al. Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. J Hepatol 2009;51(2):315-21.10.1016/j.jhep.2009.04.01119501932
  38. 38. Zhang H, Ozaki I, Hamajima H, Iwane S, Takahashi H, Kawaguchi Y, et al. Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation. Oncol Rep 2011;25(1):159-66.
  39. 39. Avior Y, Levy G, Zimerman M, Kitsberg D, Schwartz R, Sadeh R, et al. Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes. Hepatology 2015;62(1):265-78.10.1002/hep.2780325808545
  40. 40. Zhang YS, Chu JH, Cui SX, Song ZY, Qu XJ. Des-γ-carboxy prothrombin (DCP) as a potential autologous growth factor for the development of hepatocellular carcinoma. Cell Physiol Biochem 2014;34(3):903-15.10.1159/00036630825200250
  41. 41. Hitomi M, Nonomura T, Yokoyama F, Yoshiji H, Ogawa M, Nakai S, et al. In vitro and in vivo antitumor effects of vitamin K5 on hepatocellular carcinoma. Int J Oncol 2005;26(5):1337-44.10.3892/ijo.26.5.1337
  42. 42. Hitomi M, Yokoyama F, Kita Y, Nonomura T, Masaki T, Yoshiji H, et al. Anti-tumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. Int J Oncol 2005;26(3):713-20.
  43. 43. Setoguchi S, Watase D, Matsunaga K, Matsubara M, Kubo Y, Kusuda M, et al. Enhanced antitumor effects of novel intracellular delivery of an active form of menaquinone-4, menahydroquinone-4, into hepatocellular carcinoma. Cancer Prev Res (Phila) 2015;8(2):129-38.10.1158/1940-6207.CAPR-14-029225416411
  44. 44. Caviglia GP, Abate ML, Gaia S, Petrini E, Bosco C, Olivero A, et al. A Risk of hepatocellular carcinoma in HBV cirrhotic patients assessed by the combination of miR-122, AFP and PIVKA-II. Panminerva Med 2017;59(4):283-9.10.23736/S0031-0808.17.03353-528650134
  45. 45. Saitta C, Raffa G, Alibrandi A, Brancatelli S, Lombardo D, Tripodi G, et al. PIVKA-II is a useful tool for diagnostic characterization of ultra-sound-detected liver nodules in cirrhotic patients. Medicine (Baltimore) 2017;96(26):e7266.10.1097/MD.0000000000007266550004328658121
  46. 46. Ismail MM, Morsi HK, Abdulateef NA, Noaman MK, Abou El-Ella GA. Evaluation of prothrombin induced by vitamin K absence, macrophage migration inhibitory factor and Golgi protein-73 versus alpha fetoprotein for hepatocellular carcinoma diagnosis and surveillance. Scand J Clin Lab Invest 2017;77(3):175-83.10.1080/00365513.2017.128668428276727
  47. 47. Nanashima A, Taura N, Abo T, Ichikawa T, Sakamoto I, Nagayasu T, et al. Tumor marker levels before and after curative treatment of hepatocellular carcinoma as predictors of patient survival. Dig Dis Sci 2011;56(10):3086-100.10.1007/s10620-011-1796-621706206
  48. 48. Hayashi M, Shimizu T, Hirokawa F, Inoue Y, Komeda K, Asakuma M, et al. Clinicopathological risk factors for recurrence within one year after initial hepatectomy for hepatocellular carcinoma. Am Surg 2011;77(5):572-8.10.1177/000313481107700516
  49. 49. Bae HM, Lee JH, Yoon JH, Kim YJ, Heo DS, Lee HS. Protein induced by vita-min K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation. BMC Cancer 2011;11:435.10.1186/1471-2407-11-435321010821985636
  50. 50. Takada Y, Uemoto S. Liver transplantation for hepatocellular carcinoma: the Kyoto experience. J Hepatobiliary Pancreat Sci 2010;17(5):527-32.10.1007/s00534-009-0162-y19707711
  51. 51. Kaibori M, Ishizaki M, Matsui K, Kwon AH. Predictors of microvascular invasion before hepatectomy for hepatocellular carcinoma. J Surg Oncol 2010;102(5):462-810.1002/jso.2163120872949
  52. 52. Krzyżanowska P, Drzymała-Czyż S, Pogorzelski A, Duś-Żuchowska M, Skorupa W, Bober L, et al. Vitamin K status in cystic fibrosis patients with liver cirrhosis. Dig Liver Dis 2017;49(6):672-5.10.1016/j.dld.2017.01.15528185838
  53. 53. Głowacki Ł. Działanie plejotropowe witaminy K – suplementować czy nie suplementować? http://biotechnologia.pl/farmacja/dzialanie-plejotropowe-witaminy-k-suplementowac-czy-nie-suplementowac,17226 (19.07.2017).
  54. 54. Sakaue M, Mori N, Okazaki M, Kadowaki E, Kaneko T, Hemmi N, et al. Vita-min K has the potential to protect neurons from methylmercury-induced cell death in vitro. J Neurosci Res 2011;89(7):1052-8.10.1002/jnr.2263021488088
  55. 55. Delwar ZM, Avramidis D, Follin E, Hua Y, Siden Å, Cruz M, et al. Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells. Invest New Drugs 2012;30(4):1302-10.10.1007/s10637-011-9680-y21553345
  56. 56. Tsujioka T, Miura Y, Otsuki T, Nishimura Y, Hyodoh F, Wada H, et al. The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 2006;91(5):613-9.
  57. 57. Kiely M, Hodgins SJ, Merrigan BA, Tormey S, Kiely PA, O’Connor EM. Real--time cell analysis of the inhibitory effect of vitamin K2 on adhesion and proliferation of breast cancer cells. Nutr Res 2015;35(8):736-43.10.1016/j.nutres.2015.05.01426082424
DOI: https://doi.org/10.21164/pomjlifesci.477 | Journal eISSN: 2719-6313 | Journal ISSN: 2450-4637
Language: English
Page range: 39 - 44
Published on: Mar 16, 2020
Published by: Pomeranian Medical University
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2020 Aleksandra Niemiec, Urszula Stasiak, Anna Wasilewska, Dawid Przybylski, Małgorzata Marchelek-Myśliwiec, Monika Nowosiad-Magda, published by Pomeranian Medical University
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.