Abstract
Introduction: In European couples infertility varies 5–24%. The progesterone receptor (PGR) encoded by the PGR gene plays a key role in many reproductive pathways. In our study, for the first time among European populations, the potential association of PGR rs1042838 with spontaneous abortions (SA), was investigated.
Materials and methods: The TaqMan SNP assay was used in a group of 154 women with SA and 154 controls – mothers with at least 1 live-born child for genotyping the rs1042838 of
Results: The prevalence of genotypes GG, GT, TT in women with and without SAs were: 72.8%, 22.7%, 4.5% and 61.0%, 34.4% and 4.6%, respectively (p = 0.080).
Conclusions: Due to the fact that in some populations rs1042838 is rare, its confirmation as a genetic marker of SA requires further studies in larger groups and different populations.