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Cannabis Use Characteristics and PTSD-Related Outcomes Among Canadian Veterans With Chronic Pain Cover

Cannabis Use Characteristics and PTSD-Related Outcomes Among Canadian Veterans With Chronic Pain

Open Access
|Jan 2025

Figures & Tables

Table 1

Frequency Count and Percentage of Categorical Demographic Variables.

VARIABLENON-CANNABIS USERSNO CANNABIS USE IN PAST 6 MONTHSCURRENT CANNABIS USERSCOMBINED
N%N%N%N%
Total11522.427013.6532863.94513100
Sex
    Female2118.261420.004513.728015.59
    Male9380.875680.0028085.3742983.63
    Non-disclosed10.8700.0030.9140.77
Race
    White10492.866492.7529089.7845890.87
    Black00.0000.0030.9330.60
    Indigenous54.4645.80216.50305.95
    Asian/Pacific Islander00.0000.0010.3110.20
    Hispanic00.0000.0010.3110.20
    South Asian00.0011.4500.0010.20
    Mixed race32.6800.0072.17101.98
Marital Status
    Single97.9645.80237.01367.06
    Common law1815.931014.493310.066111.96
    Married6456.644362.3220361.8931060.78
    Divorced/separated1715.04913.046218.908817.25
    Widowed54.4234.3572.13152.94
Survey language
    English9784.356491.4331395.4347492.40
    French1815.6568.57154.57397.60
Highest level of education
    No highschool degree1513.3968.57267.98479.25
    Highschool2219.642231.437924.2312324.21
    College/trade school4338.393042.8616450.3123746.65
    Undergrad degree2017.86811.434212.887013.78
    Graduate degree1210.7145.71154.60316.10
CAF branch
    Army7162.834260.8719962.5831262.40
    Navy2118.58811.595717.928617.20
    Air Force2118.581927.546219.5010220.40
Rank upon release
    Junior NCM4338.392942.0316252.4323447.76
    NCO3934.823246.3811737.8618838.37
    Commissioned3026.79811.59309.716813.88
Employment
    Unemployed1815.651724.2911033.5414528.72
    Student/training10.8711.4361.8381.56
    Employed2723.482130.005316.1610119.69
    Retired6960.003144.2915948.4825950.49
Disability
    No8271.304462.8617453.0530058.48
    Yes3328.702637.1415446.9521341.52
Mental health condition
    No3933.912231.437221.9513325.93
    Yes7666.094868.5725678.0538074.07

[i] Note. NCM = Non-commissioned member, NCO = Non-commissioned officer. All percentages are calculated as valid percentages (i.e., the proportion of non-missing cases that fall into a certain category).

Table 2

Mean and Standard Deviation of Continuous Demographic Variables.

VARIABLENON-CANNABIS USERSNO CANNABIS USE IN PAST 6 MONTHSCURRENT CANNABIS USERSCOMBINED
Age60.07 (8.63)58.25 (8.59)57.35 (8.35)58.08 (8.50)
Year joined CAF1983 (10.50)1984 (10.21)1986 (10.36)1985 (10.40)
Year released from CAF2003 (15.49)2004 (13.93)2005 (12.67)2004 (13.50)
Total years of service20.43 (11.57)20.98 (11.12)19.72 (10.73)20.04 (10.96)
Years since release20.33 (15.49)19.20 (13.93)18.07 (12.67)18.71 (13.50)

[i] Notes. Numerical data format: Mean (Standard Deviation). Missing cases were excluded.

Table 3

Frequency and Impact of Cannabis Use on Mental Health Conditions in Canadian Veterans Who Use Cannabis, Have Chronic Pain, and Have a History of Trauma.

CONDITIONHAS CANNABIS USE HELPED THE FOLLOWING CONDITIONS
CANNABIS USE FOR BELOW CONDITIONSNO CHANGEHELPFULMADE IT WORSE
N%N%N%N%
PTSD17458.594023.9512776.0500.00
Depression14247.811410.0012589.2910.71
Anxiety18562.29158.1516489.1352.72
Sleep Problems22876.77177.5620792.0010.44

[i] Note. All percentages are calculated as valid percentages (i.e., the proportion of non-missing cases that fall into a certain category).

Table 4

Mean and Standard Deviation of PCL-5, PHQ-ADS, ISI, and PCL-5 Symptom Cluster Scores across Predictor Variables in Canadian Veterans with Chronic Pain and a History of Trauma.

VARIABLEnPCL-5PCL-BPCL-CPCL-DPCL-EPHQ-ADSISI
Cannabis use
    Never11432.88 (17.57)7.92 (5.03)3.67 (2.32)11.00 (6.71)10.29 (5.32)20.55 (10.54)14.78 (6.14)
    Non-current7034.54 (17.72)7.75 (5.05)3.60 (2.59)12.11 (6.96)11.08 (5.04)21.58 (10.65)15.24 (4.91)
    Current32537.00 (16.82)8.51 (4.73)4.01 (2.23)12.79 (6.54)11.69 (5.20)22.47 (10.17)15.39 (5.88)
Sex
    Female8039.09 (15.89)8.69 (4.87)4.32 (2.29)14.12 (6.15)11.97 (4.59)24.29 (8.99)16.77 (4.61)
    Male42935.12 (17.35)8.20 (4.84)3.80 (2.30)11.95 (6.71)11.17 (5.34)21.48 (10.51)14.94 (5.97)
Talk therapy attendance
    No24428.63 (15.65)6.74 (4.55)3.12 (2.21)9.58 (6.05)9.19 (4.74)18.22 (9.39)14.19 (5.57)
    Yes26542.29 (15.88)9.69 (4.68)4.58 (2.17)14.79 (6.22)13.23 (4.91)25.32 (9.99)16.19 (5.88)

[i] Notes. Numeical data format: Mean (Standard Deviation). Those who did not disclose their sex (n = 4) were excluded from analysis due to this group’s inclusion violating assumptions of the MATS (i.e., their inclusion created factor level combinations with less than two observations).

Table 5

Mean and Standard Deviation of PCL-5, PHQ-ADS, ISI, and PCL-5 Symptom Cluster Scores across Predictor Variables in Canadian Veterans Who Use Cannabis, Have Chronic Pain, and Have a History of Trauma.

NPCL-5PCL-BPCL-CPCL-DPCL-EPHQ-ADSISI
Cannabis Prescription
    No6832.48 (17.01)7.38 (4.77)3.68 (2.24)11.13 (6.37)10.29 (4.99)21.42 (9.46)14.54 (5.79)
    Yes25738.30 (16.60)8.82 (4.68)4.11 (2.22)13.27 (6.52)12.10 (5.21)22.78 (10.32)15.56 (6.04)
Preferred route of administration
    Inhaled10036.08 (16.34)8.38 (4.55)3.90 (2.18)12.64 (6.30)11.16 (5.28)22.35 (9.79)14.77 (6.27)
    Ingested10136.07 (16.19)8.09 (4.49)3.71 (2.29)12.29 (6.33)11.98 (5.16)21.90 (9.83)15.61 (5.89)
    Absorbed2933.28 (20.62)7.06 (5.12)4.09 (2.56)11.18 (8.35)10.95 (5.66)20.96 (11.37)14.79 (6.02)
    Multiple9540.38 (16.48)9.56 (4.92)4.46 (2.08)14.09 (6.27)12.27 (5.03)23.75 (10.47)15.86 (5.82)
THC:CBD ratio
    Low8237.55 (16.68)8.60 (4.79)4.02 (2.23)13.11 (6.59)11.83 (4.79)22.25 (8.66)16.08 (5.08)
    Equal12335.66 (17.12)8.57 (4.76)3.99 (2.27)11.91 (6.64)11.19 (5.43)21.62 (10.81)15.08 (6.26)
    High12038.23 (16.66)8.41 (4.70)4.06 (2.21)13.57 (6.33)12.18 (5.24)23.55 (10.37)15.13 (6.29)
Grams/day
    <3 grams15235.37 (17.35)8.08 (5.09)3.70 (2.34)12.15 (6.62)11.44 (5.09)22.00 (10.30)15.11 (5.95)
    3 grams6438.70 (17.18)8.68 (4.53)4.33 (2.16)13.33 (6.65)12.36 (5.61)23.59 (10.02)15.81 (6.42)
    >3 grams10938.52 (15.76)9.03 (4.30)4.29 (2.07)13.48 (6.30)11.72 (5.14)22.55 (10.05)15.42 (5.83)

[i] Notes. Numerical data format: Mean (Standard Deviation). Those who did not disclose their sex (n = 3) were excluded from analysis due to this group’s inclusion violating assumptions of the MATS (i.e., their inclusion created factor level combinations with less than two observations).

Table 6

MANOVAs Investigating How Cannabis Use, Talk Therapy, and Sex Impact PCL-5, PHQ-ADS, ISI, and PCL-5 Symptom Cluster Scores in Canadian Veterans Who Have Chronic Pain and a History of Trauma.

PREDICTORMANOVA
MATSap
Cannabis use MANOVA for PCL-5, PHQ-ADS, and ISI
    Cannabis use10.29.287
    Talk therapy88.78<.001
    Sex4.00.332
    Cannabis use * Talk therapy15.00.138
    Cannabis use * Sex9.04.340
    Talk therapy * Sex1.28.712
    Cannabis use * Talk therapy *Sex15.41.136
Cannabis use MANOVA for PCL-5 symptom cluster scores
    Cannabis use21.95.094
    Talk therapy166.71<.001
    Sex4.15.415
    Cannabis use * Talk therapy29.78.043
    Cannabis use * Sex3.78.797
    Talk therapy * Sex4.69.370
    Cannabis use * Talk therapy *Sex34.75.029

[i] Note. Those who did not disclose their sex (n = 4) were excluded from analysis due to this group’s inclusion violating assumptions of the MATS (i.e., their inclusion created factor level combinations with less than two observations). Statistically significant p values are bolded (i.e., p < .05).

aA MATS score quantifies the relative difference between two means and performs well with data that has homogeneous variances/covariances and non-normal distributions.

Table 7

Post hoc Analysis on Main Effect of Talk Therapy Attendance on Participants’ PCL-5, PHQ-ADS, ISI, and PCL-5 Symptom ClusterScores in Canadian Veterans Who Have Chronic Pain and a History of Trauma.

MEASUREMEAN DIFFERENCE95% CIp
Talk therapy
Yes – No
PCL-5 Total13.66[10.93, 16.40]<.001
    PCL B2.95[2.15, 3.75]<.001
    PCL C1.47[1.09, 1.85]<.001
    PCL D5.21[4.14, 6.27]<.001
    PCL E4.04[3.20, 4.88]<.001
PHQ-ADS7.10[5.42, 8.79]<.001
ISI2.01[1.01, 3.00]<.001

[i] Note. Shown p values were adjusted by the Benjamini-Hochberg adjustment to control for family-wise error rate.

Table 8

Multiple MANOVAs Investigating the Impact of Cannabis Prescription, Route of Administration, THC:CBD Ratio, and Grams/day on PCL-5, PHQ-ADS, ISI, and PCL-5 Symptom Cluster Scores in Canadian Veterans Who Use Cannabis, Have Chronic Pain, and Have a History of Trauma.

PREDICTORMANOVA
MATSaP
2 × 2 MANOVAs for cannabis prescription and sex
    Outcomes: PCL-5, PHQ-ADS, and ISI
        Cannabis prescription15.66.017
        Sex0.91.776
        Prescription * Sex3.71.317
    Outcomes: PCL-5 symptom clusters
        Cannabis prescription23.29.017
        Sex1.63.707
        Prescription * Sex2.59.547
2 × 4 MANOVAs for route of administration and sex
    Outcomes: PCL-5, PHQ-ADS, and ISI
        Cannabis route12.07.292
        Sex1.43.639
        Route * Sex6.02.697
    Outcomes: PCL-5 symptom clusters
        Cannabis route27.51.099
        Sex1.34.680
        Route * Sex9.87.571
2 × 4 MANOVAs for THC:CBD ratio and sex
    Outcomes: PCL-5, PHQ-ADS, and ISI
        THC:CBD19.18.027
        Sex5.20.182
        THC:CBD * Sex17.65.036
    Outcomes: PCL-5 symptom clusters
        THC:CBD31.96.013
        Sex3.68.377
        THC:CBD * Sex34.15.010
2 × 4 MANOVAs for grams/day and sex
    Outcomes: PCL-5, PHQ-ADS, and ISI
        Grams/day1.08.973
        Sex1.32.688
        Grams/day * Sex3.59.723
    Outcomes: PCL-5 symptom clusters
        Grams/day6.07.575
        Sex2.66.511
        Grams/day * Sex7.50.467

[i] Note. Those who did not disclose their sex (n = 3) were excluded from analysis due to this group’s inclusion violating assumptions of the MATS (i.e., their inclusion created factor level combinations with less than two observations). Statistically significant p values are bolded (i.e., p < .05).

aA MATS score quantifies the relative difference between two means and performs well with data that has homogeneous variances/covariances and non-normal distributions.

Table 9

Post hoc Analysis of the Main Effect of Cannabis Prescription on PCL-5 and Relevant PCL-5 Symptom Clustersin Canadian Veterans Who Use Cannabis, Have Chronic Pain, and Have a History of Trauma.

MEASUREMEAN DIFFERENCE95% CIp
Cannabis prescription
Yes – No
PCL-5 total5.83[1.28, 10.38].042
    PCL B1.44[0.16, 2.72].041
    PCL D2.14[0.42, 3.86].034
    PCL E1.81[0.46, 3.16].034

[i] Note. Shown p values were adjusted by the Benjamini-Hochberg adjustment to control for family-wise error rate.

jvs-11-1-582-g1.png
Language: English
Page range: 30 - 46
Submitted on: Jul 6, 2024
Accepted on: Nov 23, 2024
Published on: Jan 27, 2025
Published by: Virginia Tech Publishing
In partnership with: Paradigm Publishing Services

© 2025 Mitchell R. Sheehy, David P. Storey, Joshua A. Rash, Greg K. Tippin, Vikas Parihar, Nick Harris, published by Virginia Tech Publishing
This work is licensed under the Creative Commons Attribution 4.0 License.