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Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience Cover

Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience

Open Access
|Jul 2021

Figures & Tables

A recent study at McMaster Children's Hospital concludes that using WAPPS-generated pharmacokinetic data to personalise prophylaxis recommendations both validates clinical practice and supports patient-centred care
A recent study at McMaster Children's Hospital concludes that using WAPPS-generated pharmacokinetic data to personalise prophylaxis recommendations both validates clinical practice and supports patient-centred care

Figure 1

Change in hours per week where factor level is under 1% pre- and post-PK testing using WAPPS. Error bars represent the standard error.
Change in hours per week where factor level is under 1% pre- and post-PK testing using WAPPS. Error bars represent the standard error.

Data extracted from chart review

DATA EXTRACTED FROM CHART REVIEW
Patient demographics:
  • Age

  • Weight

  • Height

  • Baseline factor level

PK estimates calculated by the WAPPS tool
Prophylaxis regimen before PK testing
Prophylaxis regimen after PK testing
Reason for changing the prophylaxis regimen (if available)
Reason for not changing the prophylaxis regimen (if available)

Patient demographics

PATIENTS WHO HAVE CHANGED THEIR PROPHYLAXIS REGIMEN AFTER PK TESTINGPATIENTS WHO HAVE NOT CHANGED THEIR PROPHYLAXIS REGIMEN AFTER PK TESTING
Age
Mean ± SD10.61 ± 4.169.89 ± 3.26
(Minimum, Maximum)(2, 15)(3, 15)

Weight (kg)
Mean ± SD45.72 ± 20.8337.52 ± 14.53
(Minimum, Maximum)(14, 76.9)(14.5, 66.2)

Height (cm)
Mean ± SD149.12 ± 31.89140.99 ± 20.75
(Minimum, Maximum)(81, 184)(95.8, 175)

Changes to prophylaxis regimen after WAPPS

CHANGES TO PROPHYLAXIS REGIMEN
DOSAGEFREQUENCYDRUGNUMBER OF PATIENTS (N)
8
1
1
1
1
Changed1
DOI: https://doi.org/10.17225/jhp00179 | Journal eISSN: 2055-3390
Language: English
Page range: 80 - 85
Published on: Jul 13, 2021
Published by: Haemnet Ltd
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2021 Celia Kwan, Mihir D. Bhatt, Karen Strike, Kay Decker, Davide Matino, Anthony K.C. Chan, published by Haemnet Ltd
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.