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Improvement in school absence after factor replacement in students with haemophilia in Upper Assam, India Cover

Improvement in school absence after factor replacement in students with haemophilia in Upper Assam, India

Open Access
|Nov 2020

Figures & Tables

In countries with limited resources, a regimen of low dose prophylaxis or access to on-demand therapy with factor replacement can help to improve bleeding rates, joint health and functional ability for children with haemophilia, thereby improving school attendance.
In countries with limited resources, a regimen of low dose prophylaxis or access to on-demand therapy with factor replacement can help to improve bleeding rates, joint health and functional ability for children with haemophilia, thereby improving school attendance.

Characteristics of participants

VARIABLEPROPHYLAXIS MEAN (±SD)ON-DEMAND MEAN (±SD)
Age at enrolment (years)13.1(±4.5)11.7(+4.5)
Duration of prophylaxis (years)1.4(±0.2)
Haemophilia type
Haemophilia A2110
Haemophilia B52

Correlation between school absences and ABR, HJHS and FISH during prophylaxis and on-demand treatment

BEFORE ENROLMENTP-VALUEAFTER ENROLMENTP-VALUE
Prophylaxis
ABR0.5140.0090.639<0.001
HJHS0.3250.1120.1560.446
FISH−0.751<0.001−0.694<0.001
On-demand
ABR0.874<0.0010.3960.203
HJHS0.6900.0130.1970.539
FISH−0.7980.002−0.5800.048

Days of school absence (per month) in the year before and after enrolment with HTC

VARIABLEBEFORE ENROLMENT MEAN(±SD)AFTER ENROLMENT MEAN(±SD)P-VALUE*
Number of days absent (prophylaxis)15(+6)4(+3)<0.001
Number of days absent (on-demand)10(+5)3(+2)0.477
Scores during prophylaxis
ABR37.8(±20.0)5.8(±4.6)<0.001
HJHS31.1(±18.1)4.7(±4.6)<0.001
FISH21.4(±4.2)27.9(±3.3)<0.001
Scores during on-demand treatment
ABR25.5(±19.9)8.7(±6.2)0.006
HJHS13.8(±11.4)3.1(±4.2)0.002
FISH24.6(±4.5)29.1(±2.6)<0.001
DOI: https://doi.org/10.17225/jhp00166 | Journal eISSN: 2055-3390
Language: English
Page range: 136 - 142
Published on: Nov 19, 2020
Published by: Haemnet Ltd
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2020 Anupam Dutta, Dipjyoti Boruah, Taniya Sarkar Dutta, Angshuman Boruah, Bhabani Shankar Dhal, published by Haemnet Ltd
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.