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Predictors of treatment adherence in patients with chronic disease using the Multidimensional Adherence Model: unique considerations for patients with haemophilia Cover

Predictors of treatment adherence in patients with chronic disease using the Multidimensional Adherence Model: unique considerations for patients with haemophilia

The Journal of Haemophilia Practice
Volume 7 (2020): Issue 1 (January 2020)
By: Karen Strike,  Anthony Chan,  Alfonso Iorio,  Monica R. Maly,  Paul W. Stratford and  Patricia Solomon  
Open Access
|Jul 2020

Figures & Tables

Adherence to prophylaxis among people with haemophilia is known to be variable. A retrospective study of patients treated at an urban haemophilia treatment centre in Canada suggests there may be predictors of adherence beyond the WHO's inclusive Multidimensional Adherence Model.© Shutterstock
Adherence to prophylaxis among people with haemophilia is known to be variable. A retrospective study of patients treated at an urban haemophilia treatment centre in Canada suggests there may be predictors of adherence beyond the WHO's inclusive Multidimensional Adherence Model.© Shutterstock

Figure 1

World Health Organization Multidimensional Adherence Model[15]
World Health Organization Multidimensional Adherence Model[15]

Characteristics of outcome and explanatory variables

VARIABLENMEAN/SDMIN/MAX (%)
Objective measure of adherence†8793.55/24.750/154%
NMEDIAN1ST & 3RD QUARTILES
Subjective measure of adherence‡878151, 98
ABR§8720, 4
Age872110, 36
Distance from HTC††875126, 71
HJHS‡‡7610.51, 23.5
CATEGORIESCOUNTSPERCENTAGE OF SAMPLE
Infusion frequency§§189%
22023%
32124%
43034%
522%
611%
756%

Correlation matrixCorrelation co-efficient of the explanatory variables with both measures of adherence

SUBJECTIVEOBJECTIVEHJHSAGEFREQUENCYABRDISTANCE
Subjective‡1.0000
Objective†0.45681.0000
HJHS‡‡−0.02280.06511.0000
Age0.01280.03750.85731.0000
Frequency§§0.0402−0.1959−0.0250−0.03511.0000
ABR§−0.08610.03100.34380.2597−0.02361.0000
Distance††0.0977−0.03070.04420.0690−0.03460.20381.0000

Full model stepwise regression for the objective measure of adherence

VARIABLEβ-COEFFICIENTSTD ERRORP-VALUE95%CI
Frequency−672.394324.5060.041−1317.599, −27.189
_cons†11536.881147.5660.0009255.207, 13818.54
DOI: https://doi.org/10.17225/jhp00152 | Journal eISSN: 2055-3390
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Language: English
Page range: 92 - 101
Published on: Jul 25, 2020
Published by: Haemnet Ltd
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Treatment adherence and compliance,
chronic disease,
haemophilia A,
haemophilia B,
model, theoretical,
prophylaxis
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other,
Pharmacy,
Pharmacology

© 2020 Karen Strike, Anthony Chan, Alfonso Iorio, Monica R. Maly, Paul W. Stratford, Patricia Solomon, published by Haemnet Ltd
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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