Valproate (VPA)-Associated Hepatotoxicity

J Gordon Millichap

doi:10.15844/pedneurbriefs-7-5-12

Valproate (VPA)-Associated Hepatotoxicity

Pediatric Neurology Briefs

Volume 7 (1993): Issue 5

By: J Gordon Millichap

Open Access

|May 1993

Abstract

The metabolic pattern of VPA in 170 epileptic patients without symptoms or signs of hepatic side effects was compared to that in 11 patients with early symptoms and signs of hepatotoxicity and in 5 children with fulminant liver failure.

References

Siemes H Nau H Schultze K Wittfoht W Drews E Penzien J Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity Epilepsia 1993 Mar-Apr 34 2 332 46 8453944 10.1111/j.1528-1157.1993.tb02419.x
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Appleton RE Farrell K Applegarth DA Dimmick JE Wong LT Davidson AG The high incidence of valproate hepatotoxicity in infants may relate to familial metabolic defects Can J Neurol Sci 1990 May 17 2 145 8 2113424
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-7-5-12 | Journal eISSN: 2166-6482

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Language: English

Page range: 40 - 40

Published on: May 1, 1993

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Hepatic Side Effects,

Potential Hepatotoxin,

Valproate

© 1993 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 7 (1993): Issue 5