Studies of cerebral oxidative metabolism were carried out by phosphorus magnetic resonance spectroscopy during the first week of life in 52 infants with birth asphyxia admitted to the Neonatal Unit at University College Hospital, London. Cerebral phosphocreatine/inorganic phosphate concentration ratio was used as an index of oxidative metabolism and correlated with neurodevelopmental outcome and head growth at 1 year. [1]
COMMENT. The use of these neuroimaging and biochemical techniques should help in the prediction of outcome following neonatal encephalopathy. However, the complexity of the techniques may detract from their value in practice. [2]
Central diabetes insipidus as an unusual complication of hypoxic brain damage is described in 2 children at the Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan [3]. Both patients developed cardiopulmonary arrest after choking and both had hypernatremia and low urinary antidiuretic hormone concentrations in the terminal stages. The most common causes of central diabetes insipidus are tumors or trauma in the neurohypophyseal area.