Genetic Factors Associated with Phenytoin-Related Skin Reactions

J Gordon Millichap; John J Millichap

doi:10.15844/pedneurbriefs-28-9-1

Genetic Factors Associated with Phenytoin-Related Skin Reactions

Pediatric Neurology Briefs

Volume 28 (2014): Issue 9

By: J Gordon Millichap and John J Millichap

Open Access

|Sep 2014

Abstract

Investigators at the Taipei Medical University Hospital and other centers in Taiwan conducted a case-control study in 2002-2014 among 105 cases with phenytoin-related severe cutaneous adverse reactions (n = 61 Stevens-Johnson syndrome/toxic epidermal necrolysis and n = 44 drug reactions with eosinophilia and systemic symptoms), 78 cases with maculopapular exanthema, 130 phenytoin-tolerant control participants, and 3655 population controls from Taiwan, Japan, and Malaysia.

References

Chung WH Chang WC Lee YS Wu YY Yang CH Ho HC for the Taiwan Severe Cutaneous Adverse Reaction Consortium and the Japan Pharmacogenomics Data Science Consortium Genetic variants associated with phenytoin-related severe cutaneous adverse reactions JAMA 2014 Aug 6 312 5 525 34 10.1001/jama.2014.7859 25096692
Open DOI Search in Google Scholar Back to article
Gau SS Chao PF Lin YJ Chang CJ Gau CS The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study J Clin Psychopharmacol 2008 Oct 28 5 509 17 10.1097/JCP.0b013e3181845610 18794645
Open DOI Search in Google Scholar Back to article
Khafaga YM Jamshed A Allam AA Mourad WA Ezzat A Al Eisa A Stevens-Johnson syndrome in patients on phenytoin and cranial radiotherapy Acta Oncol 1999 38 1 111 6 10.1080/028418699431898 10090698
Open DOI Search in Google Scholar Back to article
Young B Rapp RP Norton JA Haack D Walsh JW Failure of prophylactically administered phenytoin to prevent post-traumatic seizures in children Child's Brain 1983 10 3 185 92 10.1159/000120113 6409521
Open DOI Search in Google Scholar Back to article
Rapp RP Norton JA Young B Tibbs PA Cutaneous reactions in head-injured patients receiving phenytoin for seizure prophylaxis Neurosurgery 1983 Sep 13 3 272 5 6225961
Search in Google Scholar Back to article
Locharernkul C Loplumlert J Limotai C Korkij W Desudchit T Tongkobpetch S Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population Epilepsia 2008 Dec 49 12 2087 91 10.1111/j.1528-1167.2008.01719.x 18637831
Open DOI Search in Google Scholar Back to article
Wang W Hu FY Wu XT An DM Yan B Zhou D Genetic predictors of Stevens-Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population Epilepsy Behav 2014 Jun 17 37C 16 19 10.1016/j.yebeh.2014.05.025 24949577
Open DOI Search in Google Scholar Back to article
He XJ Jian LY He XL Tang M Wu Y Xu YY Association of ABCB1, CYP3A4, EPHX1, FAS, SCN1A, MICA, and BAG6 polymorphisms with the risk of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Chinese Han patients with epilepsy Epilepsia 2014 Aug 55 8 1301 6 10.1111/epi.12655 24861996
Open DOI Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-28-9-1 | Journal eISSN: 2166-6482

Journal RSS Feed

Language: English

Page range: 65 - 66

Published on: Sep 1, 2014

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Phenytoin-Related,

Stevens-Johnson Syndrome,

Toxic Epidermal Necrolysis

© 2014 J Gordon Millichap, John J Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 28 (2014): Issue 9