Effect of Neonatal Exposure to AED on Synaptic Maturation

J Gordon Millichap

doi:10.15844/pedneurbriefs-26-11-9

Effect of Neonatal Exposure to AED on Synaptic Maturation

Pediatric Neurology Briefs

Volume 26 (2012): Issue 11

By: J Gordon Millichap

Open Access

|Nov 2012

Abstract

Pharmacologists at Georgetown University, Washington, DC examined functional synaptic maturation in striatal medium spiny neurons from neonatal rats exposed to antiepileptic drugs (AED) with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proapoptotic action (levetiracetam).

References

Forcelli PA Janssen MJ Vicini S Gale K Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development Ann Neurol 2012 Sep 72 3 363 72 10.1002/ana.23600 22581672
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Putnam TJ Merritt HH EXPERIMENTAL DETERMINATION OF THE ANTICONVULSANT PROPERTIES OF SOME PHENYL DERIVATIVES Science 1937 May 28 85 2213 525 6 10.1126/science.85.2213.525 17750072
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-26-11-9 | Journal eISSN: 2166-6482

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Language: English

Page range: 86 - 87

Published on: Nov 1, 2012

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Phenobarbital,

Phenytoin,

Lamotrigine

© 2012 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 26 (2012): Issue 11