Reversible Valproate Hepatotoxicity and Associated Mitochondrial Disease

J Gordon Millichap

doi:10.15844/pedneurbriefs-22-2-4

Reversible Valproate Hepatotoxicity and Associated Mitochondrial Disease

Pediatric Neurology Briefs

Volume 22 (2008): Issue 2

By: J Gordon Millichap

Open Access

|Feb 2008

Abstract

A 2-year-old boy with seizures complicated by reversible valproate-induced hepatic failure was subsequently found to have mitochondrial polymerase g gene (POLG1) mutations typical of Alpers-Huttenlocher disease, in a study at Newcastle University, UK.

References

McFarland R Hudson G Taylor RW Green SH Hodges S McKiernan PJ Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1) Arch Dis Child 2008 Feb 93 2 151 3 10.1136/adc.2007.122911 18208989
Open DOI Search in Google Scholar Back to article
Wiltshire E Davidzon G DiMauro S Akman HO Sadleir L Haas L Juvenile Alpers disease Arch Neurol 2008 Jan 65 1 121 4 10.1001/archneurol.2007.14 18195149
Open DOI Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-22-2-4 | Journal eISSN: 2166-6482

Journal RSS Feed

Language: English

Page range: 12 - 12

Published on: Feb 1, 2008

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Hepatotoxicity,

Mitochondrial,

Alpers-Huttenlocher Syndrome

© 2008 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 22 (2008): Issue 2