Stroke Prevention Trials in Sickle Cell Anemia

J Gordon Millichap

doi:10.15844/pedneurbriefs-20-6-10

Stroke Prevention Trials in Sickle Cell Anemia

Pediatric Neurology Briefs

Volume 20 (2006): Issue 6

By: J Gordon Millichap

Open Access

|Jun 2006

Abstract

As part of an International Pediatric Stroke Study launched in 2002, the Stroke Prevention Trial in Sickle Cell Anemia (STOP) reports a reduction in the number of overt clinical strokes in children with critically high transcranial Doppler velocities (>200 cm/sec) who were regularly transfused.

References

Adams RJ McKie VC Hsu L Files B Vichinsky E Pegelow C Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography N Engl J Med 1998 Jul 339 1 5 11 10.1056/NEJM199807023390102 9647873
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Adams RJ Brambilla D Optimizing Primary Stroke Prevention in Sickle Cell Anemia (STOP 2) Trial Investigators Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease N Engl J Med 2005 Dec 353 26 2769 2778 10.1056/NEJMoa050460 16382063
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Kirkham FJ Lerner NB Noetzel M DeBaun MR Datta AK Rees DC Trials in sickle cell disease Pediatr Neurol 2006 Jun 34 6 450 458 10.1016/j.pediatrneurol.2005.10.017 16765823
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Millichap JG Sickle cell disease and electroencephalography hyperventilation Ann Neurol 2005 Dec 58 6 972 10.1002/ana.20695 16315282
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-20-6-10 | Journal eISSN: 2166-6482

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Language: English

Page range: 48 - 48

Published on: Jun 1, 2006

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Stroke Prevention Trial in Sickle Cell Anemia,

Doppler Screening,

Hyperventilation

© 2006 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 20 (2006): Issue 6