Motor Impairments in Angelman Syndrome

Of 33 children and adolescents (median age 6 years) investigated for learning disability, epilepsy, and motor dysfunction to detect suspected Angelman syndrome (AS), in a study at Goteborg University, Sweden, 23 fulfilled criteria for AS. Distal lower limb spasticity, ataxic like gait with hand flapping, and muscle weakness, milder than findings in most CP, were significantly more frequent in AS than in a comparison group. [1]