Drug-Transporter Gene and Refractory Epilepsy

J Gordon Millichap

doi:10.15844/pedneurbriefs-17-5-1

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Drug-Transporter Gene and Refractory Epilepsy

Pediatric Neurology Briefs

Volume 17 (2003): Issue 5

By: J Gordon Millichap

Open Access

|May 2003

Abstract

The drug-transporter gene ABCB1 polymorphism (C to T) at position 3435 was typed in 315 patients with epilepsy, classified as drug-resistant in 200 and drug-responsive in 115, and 200 controls without epilepsy, in a study at the Institute of Neurology, London, UK.

References

Siddiqui A Kerb R Weale ME Brinkmann U Smith A Goldstein DB Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 N Engl J Med 2003 Apr 10 348 15 1442 8 10.1056/NEJMoa021986 12686700
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Pedley TA Hirano M Is refractory epilepsy due to genetically determined resistance to antiepileptic drugs? N Engl J Med 2003 Apr 10 348 15 1480 2 10.1056/NEJMe030023 12686705
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Remy S Gabriel S Urban BW Dietrich D Lehmann TN Elger CE A novel mechanism underlying drug resistance in chronic epilepsy Ann Neurol 2003 Apr 53 4 469 79 10.1002/ana.10473 12666114
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-17-5-1 | Journal eISSN: 2166-6482

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Language: English

Page range: 33 - 34

Published on: May 1, 2003

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Antiepileptic Drugs,

Drug-Responsive Patients,

C Polymorphism

© 2003 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 17 (2003): Issue 5