Mechanism of Anticonvulsant Action of ACTH

J Gordon Millichap

doi:10.15844/pedneurbriefs-15-3-10

Mechanism of Anticonvulsant Action of ACTH

Pediatric Neurology Briefs

Volume 15 (2001): Issue 3

By: J Gordon Millichap

Open Access

|Mar 2001

Abstract

The hypothesis that systemic or intraventricular administration of corticotropin (ACTH) acts directly on limbic neurons to modulate corticotropin-releasing hormone (CRH) gene expression, independently of adrenal stimulation, was tested and confirmed in experiments on developing rats (9-11 days postnatal) at the University of California, Irvine.

References

Brunson KL Khan N Eghbal-Ahmadi M Baram TZ Corticotropin (ACTH) acts directly on amygdala neurons to down-regulate corticotropin-releasing hormone gene expression Ann Neurol 2001 Mar 49 3 304 312 10.1002/ana.66 11261504
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Snead OC 3rd How does ACTH work against infantile spasms? Bedside to bench Ann Neurol 2001 Mar 49 3 288 289 10.1002/ana.63 11261501
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-15-3-10 | Journal eISSN: 2166-6482

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Language: English

Page range: 24 - 24

Published on: Mar 1, 2001

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Administration of Corticotropin,

Corticotropin-Releasing Hormone,

Melanocortin Receptors

© 2001 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 15 (2001): Issue 3