Multicystic changes in the gyrus rectus of the left frontal lobe were demonstrated by brain magnetic resonance imaging in an 11-year-old boy with Tourette syndrome reported from Children’s Regional Hospital at Cooper Hospital/University Medical Center, Camden, NJ. Symptoms and signs of comorbid ADHD or obsessive compulsive disorder were absent. Tics responded to low dose clonidine therapy. [1]
COMMENT. Neurobiologic studies of Tourette syndrome (TS) have previously demonstrated that the prefrontal and cingulate gyrus, midbrain, corpus callosum, limbic system, and thalamus may be involved in the pathophysiology of TS. The above case-report suggests that the gyrus rectus may also be implicated in TS, independent of the basal ganglia. (see Progress in Pediatric Neurology III. PNB Publ, 1997;pp321-323).