Improved strength and functional abilities following IV immunoglobulin treatment for chronic dermatomyositis is reported in two children from the University of Mississippi Medical Center, Jackson, MS. Both patients had developed side effects during prior treatment with prednisone and immunosuppressive agents. The response to IVIG was slow and occurred in a stepwise fashion after repeated monthly courses (2 g/kg). The rash on the face and hands also resolved. [1]
COMMENT. The authors consider IVIG a useful adjuvant therapy for dermatomyositis, permitting reduction in steroid dosage and lessening of treatment morbidity.