The diagnostic significance of enamel pits in shed deciduous teeth from 20 patients with tuberous sclerosis was investigated at the University of Copenhagen, Denmark. Examination with a surface microscope found enamel pits in all 87 teeth obtained from 20 tuberous sclerosis patients, but none in 253 deciduous teeth from 142 patients with cerebral palsy, phenylketonuria and Down syndrome, as well as healthy controls. The facial surfaces of the central incisor, lateral incisor and canine teeth were most frequently affected. [1]
COMMENT. The occurrence of enamel pits in deciduous and permanent teeth may be a useful diagnostic criterion for tuberous sclerosis. Examination of the labial surfaces of the cleaned central and lateral incisors and canine teeth, using a magnifying glass, may be as important as the search for hypopigmented macules on the skin.