Valproate Hepatotoxicity in Children with Epilepsy

J Gordon Millichap

doi:10.15844/pedneurbriefs-1-1-2

Valproate Hepatotoxicity in Children with Epilepsy

Pediatric Neurology Briefs

Volume 1 (1987): Issue 1

By: J Gordon Millichap

Open Access

|Jun 1987

Abstract

Authors from the University Children’s Hospital in Heidelberg estimate the incidence of fatal valproate (VPA) hepatotoxicity in West Germany at around 1 in 5000 and find it hard to justify the use of VPA as a drug of first choice for children with generalised epilepsies.

References

Scheffner D Fatal liver failure in children on valproate Lancet 1986 Aug 30 2 8505 511 10.1016/S0140-6736(86)90376-4 2875255
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Scheffner D König S Valproate hepatotoxicity Lancet 1987 Feb 14 1 8529 389 90 10.1016/S0140-6736(87)91767-3 2880197
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Dreifuss FE Santilli N Neurology 1986 36 Suppl 1 175
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Dreifuss FE Santilli N Langer DH Sweeney KP Moline KA Menander KB Valproic acid hepatic fatalities: a retrospective review Neurology 1987 Mar 37 3 379 85 10.1212/WNL.37.3.379 3102998
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Jeavons PM Non-dose-related side effects of valproate Epilepsia 1984 25 Suppl 1 S50 5 10.1111/j.1528-1157.1984.tb05638.x 6425047
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Articles in this issue

DOI: https://doi.org/10.15844/pedneurbriefs-1-1-2 | Journal eISSN: 2166-6482

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Language: English

Page range: 1 - 2

Published on: Jun 1, 1987

Published by: Pediatric Neurology Briefs Publishers

In partnership with: Paradigm Publishing Services

Keywords:

Fatal Valproate,

Single High-Risk,

Polytherapy

© 1987 J Gordon Millichap, published by Pediatric Neurology Briefs Publishers
This work is licensed under the Creative Commons Attribution 4.0 License.

Volume 1 (1987): Issue 1