Figure 1
Figure 2
Figure 3
Predictors of severe hypoglycaemia in a fully adjusted negative binomial model_
| VARIABLES | HR | 95% C.I. | P-VALUE |
|---|---|---|---|
| Age (years) | 0.99 | 0.96, 1.02 | 0.556 |
| Female gender | 0.80 | 0.36, 1.78 | 0.585 |
| HbA1c (%) | 1.01 | 0.98, 1.04 | 0.441 |
| Diabetes duration (years) | 1.02 | 0.94, 1.11 | 0.594 |
| Type of insulin therapy | |||
| Short-acting (reference) | - | - | - |
| Long-acting | 0.54 | 0.10, 3.07 | 0.489 |
| Long and short-acting | 0.70 | 0.21, 2.28 | 0.550 |
| Mixed | NC | NC | NC |
| Other | 0.36 | 0.08, 1.57 | 0.175 |
| Blood glucose testing (per day) | 1.08 | 0.84, 1.38 | 0.555 |
| Hypoglycaemia unawareness | 1.00 | 0.44, 2.24 | 0.996 |
| Fear of hypoglycaemia | 1.20 | 1.05, 1.37 | 0.009 |
| Diabetes type 2 | 0.72 | 0.20, 2.67 | 0.627 |
Baseline characteristics of patients included_
| DM type 1 | DM type 2 | |
|---|---|---|
| N=84 | N=227 | |
| Age (years) | 49±13 | 64±10 |
| Gender (male/female, %) | 57/43 | 62/38 |
| Diabetes duration (years) | 21±11 | 16±9 |
| Insulin therapy duration (years) | 19±12 | 6 (3, 10) Non-normally distributed variables are represented as median (25th, 75th percentile) |
| HbA1c (%) | 9.2±2.7 | 9.3±2.8 |
| Employed/unemployed/retired/other (%) | 65/5/28/12 | 15/8/75/2 |
| Diabetes treatment | ||
| Short-acting insulin | 85.7 | 48.9 |
| Long-acting insulin | 60.7 | 63.1 |
| Pre-mixed insulin | 1.2 | 35.1 |
| Oral therapy | 4.8 | 24.9 |
| Injectable non-insulin therapy | 3.6 | 10.2 |
| Insulin pump | 32.1 | 4.9 |
| Self-measurement of blood glucose (%) | 98.8 | 99.6 |
| Continuous glucose measurement (%) | 34.2 | 38.4 |
| Hypoglycaemia experience (%) | 98.8 | 89.2 |