Have a personal or library account? Click to login
Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih Cover

Endocrine and Metabolic Effects of Adipose Tissue in Children and Adolescents / Endokrina in Presnovna Funkcija Maščobnega Tkiva Pri Otrocih in Mladostnikih

Open Access
|Mar 2015

References

  1. 1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.10.1038/372425a0
  2. 2. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ. et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-5.10.1016/S0092-8674(00)81294-5
  3. 3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-6.10.1126/science.76247777624777
  4. 4. Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995; 1: 950-3.10.1038/nm0995-9507585223
  5. 5. Caprio S, Tamborlane WV, Silver D, Robinson C, Leibel R, McCarthy S. et al. Hyperleptinemia: an early sign of juvenile obesity: relations to body fat depots and insulin concentrations. Am J Physiol 1996; 271: E626-30.10.1152/ajpendo.1996.271.3.E6268843759
  6. 6. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C. et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-103.10.1172/JCI0215693
  7. 7. Fiorenza CG, Chou SH, Mantzoros CS. Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol 2011; 7: 137-50.10.1038/nrendo.2010.199315073521079616
  8. 8. Hebebrand J, Muller TD, Holtkamp K, Herpertz-Dahlmann B. The role of leptin in anorexia nervosa: clinical implications. Mol Psychiatry 2007; 12: 23-35.10.1038/sj.mp.400190917060920
  9. 9. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-5.10.1056/NEJM1996020133405038532024
  10. 10. Holm JC, Gamborg M, Kaas-Ibsen K, Gammeltoft S, Ward L, Heitmann BL. et al. Time course and determinants of leptin decline during weight loss in obese boys and girls. Int J Pediatr Obes 2007; 2: 2-10.10.1080/1747716060099150917763005
  11. 11. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W. et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100: 808-13.10.1172/JCI119595
  12. 12. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T. et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999; 282: 1568-75.10.1001/jama.282.16.1568
  13. 13. Steinberg GR, Parolin ML, Heigenhauser GJ, Dyck DJ. Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance. Am J Physiol Endocrinol Metab 2002; 283: E187-92.10.1152/ajpendo.00542.2001
  14. 14. Steinberg GR, Smith AC, Van Denderen BJ, Chen Z, Murthy S, Campbell DJ. et al. AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females. J Clin Endocrinol Metab 2004; 89: 4575-80.10.1210/jc.2004-0308
  15. 15. Yoshinaga M, Sameshima K, Tanaka Y, Wada A, Hashiguchi J, Tahara H. et al. Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children. Circ J 2008; 72: 1874-8.10.1253/circj.CJ-08-0180
  16. 16. Kim IK, Kim J, Kang JH, Song J. Serum leptin as a predictor of fatty liver in 7-year-old Korean children. Ann Nutr Metab 2008; 53: 109-16.10.1159/000165360
  17. 17. Fantuzzi G. Three questions about leptin and immunity. Brain Behav Immun 2009; 23: 405-10.10.1016/j.bbi.2008.10.007
  18. 18. Reseland JE, Gordeladze JO. Role of leptin in bone growth: central player or peripheral supporter? FEBS Lett 2002; 528: 40-2.
  19. 19. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100: 197-207.10.1016/S0092-8674(00)81558-5
  20. 20. Lang K, Ratke J. Leptin and adiponectin: new players in the field of tumor cell and leukocyte migration. Cell Commun Signal 2009; 7: 27.10.1186/1478-811X-7-27280460420030801
  21. 21. von SJ, Moss A, Nagel SA. et al. Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism. Horm Res Paediatr 2012; 77: 127-33.10.1159/00033600322343341
  22. 22. von SJ, Moss A, Nagel SA, Muehleder H, Debatin KM, Farooqi IS. et al. Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism. Horm Res Paediatr 2012; 77: 127-33.10.1159/00033600322343341
  23. 23. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S. et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579-86.10.1172/JCI25977129725016322796
  24. 24. Misra M. Obesity pharmacotherapy: current perspectives and future directions. Curr Cardiol Rev 2013; 9: 33-54.
  25. 25. Retnakaran R, Youn BS, Liu Y, Hanley AJ, Lee NS, Park JW. et al. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Clin Endocrinol (Oxf) 2008; 69: 885-93.10.1111/j.1365-2265.2008.03264.x18410550
  26. 26. Cambuli VM, Musiu MC, Incani M, Paderi M, Serpe R, Marras V. et al. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol Metab 2008; 93: 3051-7.10.1210/jc.2008-047618492759
  27. 27. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697-703.10.1074/jbc.271.18.106978631877
  28. 28. Matsubara M, Maruoka S, Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol 2002; 147: 173-80.10.1530/eje.0.147017312153737
  29. 29. Bauche IB, El Mkadem SA, Pottier AM, Senou M, Many MC, Rezsohazy R. et al. Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation. Endocrinology 2007; 148: 1539-49.10.1210/en.2006-083817204560
  30. 30. Horenburg S, Fischer-Posovszky P, Debatin KM, Wabitsch M. Influence of sex hormones on adiponectin expression in human adipocytes. Horm Metab Res 2008; 40: 779-86.10.1055/s-0028-108378018792884
  31. 31. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S. et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423: 762-9.10.1038/nature0170512802337
  32. 32. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006; 116: 1784-92.10.1172/JCI29126148317216823476
  33. 33. Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H. et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003; 361: 226-8.10.1016/S0140-6736(03)12255-6
  34. 34. Nakashima R, Kamei N, Yamane K, Nakanishi S, Nakashima A, Kohno N. Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J Clin Endocrinol Metab 2006; 91: 3873-7.10.1210/jc.2006-1158
  35. 35. Fisher FM, Trujillo ME, Hanif W, Barnett AH, McTernan PG, Scherer PE. et al. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo- Asian males. Diabetologia 2005; 48:1084-7.10.1007/s00125-005-1758-7
  36. 36. Panagopoulou P, Galli-Tsinopoulou A, Fleva A, Pavlitou-Tsiontsi E, Vavatsi-Christaki N, Nousia-Arvanitakis S. Adiponectin and insulin resistance in childhood obesity. J Pediatr Gastroenterol Nutr 2008; 47: 356-62.10.1097/MPG.0b013e31817fcb67
  37. 37. Murphy MJ, Hosking J, Metcalf BS, Voss LD, Jeffery AN, Sattar N. et al. Distribution of adiponectin, leptin, and metabolic correlates of insulin resistance: a longitudinal study in British children; 1: prepuberty (EarlyBird 15). Clin Chem 2008; 54: 1298-306.10.1373/clinchem.2008.103499
  38. 38. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K. et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002; 51: 536-40.10.2337/diabetes.51.2.536
  39. 39. Poitou C, Lacorte JM, Coupaye M, Bertrais S, Bedel JF, Lafon N. et al. Relationship between single nucleotide polymorphisms in leptin, IL6 and adiponectin genes and their circulating product in morbidly obese subjects before and after gastric banding surgery. Obes Surg 2005; 15: 11-23.10.1381/0960892052993431
  40. 40. Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA. et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002; 360: 57-8.10.1016/S0140-6736(02)09335-2
  41. 41. Kubota N, Terauchi Y, Kubota T, Kumagai H, Itoh S, Satoh H. et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 2006; 281: 8748-55.10.1074/jbc.M50564920016431926
  42. 42. Motoshima H, Wu X, Mahadev K, Goldstein BJ. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004; 315: 264-71.10.1016/j.bbrc.2004.01.04914766203
  43. 43. Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 2004; 40: 46-54.
  44. 44. Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: a systematic review. Br J Cancer 2006; 94: 1221-5.10.1038/sj.bjc.6603051236139716570048
  45. 45. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schon MR. et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 2005; 54: 2911-6.10.2337/diabetes.54.10.291116186392
  46. 46. Pagano C, Pilon C, Olivieri M, Mason P, Fabris R, Serra R. et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans. J Clin Endocrinol Metab 2006; 91: 3165-70.10.1210/jc.2006-036116720654
  47. 47. Haider DG, Holzer G, Schaller G, Weghuber D, Widhalm K, Wagner O. et al. The adipokine visfatin is markedly elevated in obese children. J Pediatr Gastroenterol Nutr 2006; 43: 548-9.10.1097/01.mpg.0000235749.50820.b317033537
  48. 48. Jin H, Jiang B, Tang J, Lu W, Wang W, Zhou L. et al. Serum visfatin concentrations in obese adolescents and its correlation with age and high-density lipoprotein cholesterol. Diabetes Res Clin Pract 2008; 79: 412-8.10.1016/j.diabres.2007.09.01918241953
  49. 49. Belo VA, Souza-Costa DC, Lacchini R, Sertório JT, Lanna CM, Carmo VP. et al. Adiponectin associates positively with nitrite levels in children and adolescents. Int J Obes (Lond) 2013; 37: 740-3.10.1038/ijo.2012.10422751257
  50. 50. Li RZ, Ma X, Hu XF, Kang SX, Chen SK, Cianflone K. et al. Elevated visfatin levels in obese children are related to proinflammatory factors. J Pediatr Endocrinol Metab 2013; 26: 111-8.
  51. 51. Taskesen D, Kirel B, Us T. Serum visfatin levels, adiposity and glucose metabolism in obese adolescents. J Clin Res Pediatr Endocrinol 2012; 4: 76-81. 10.4274/Jcrpe.547
  52. 52. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K. et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426-30.10.1126/science.109724315604363
  53. 53. Varma V, Yao-Borengasser A, Rasouli N, Bodles AM, Phanavanh B, Lee MJ. et al. Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation. J Clin Endocrinol Metab 2007; 92: 666-72.10.1210/jc.2006-1303289341617090638
  54. 54. Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A. et al. Nampt/PBEF/ Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007; 6: 363-75.10.1016/j.cmet.2007.09.003209869817983582
  55. 55. Spinnler R, Gorski T, Stolz K, Schuster S, Garten A, Beck-Sickinger AG. et al. The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PLoS One 2013; 8: e54106.10.1371/journal.pone.0054106
  56. 56. Haider DG, Schaller G, Kapiotis S, Maier C, Luger A, Wolzt M. The release of the adipocytokine visfatin is regulated by glucose and insulin. Diabetologia 2006; 49: 1909-14.10.1007/s00125-006-0303-7
  57. 57. Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, Ludvik B. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. J Clin Endocrinol Metab 2006; 91: 1578-81.10.1210/jc.2005-2248
  58. 58. Pfutzner A, Marx N, Walcher D, Lobig M, Seidel D, Forst T. Impact of rosiglitazone on visfatin and adiponectin plasma concentrations in patients with type 2 diabetes and coronary artery disease. Clin Lab 2008; 54: 237-41.
  59. 59. Friebe D, Neef M, Kratzsch J, Erbs S, Dittrich K, Garten A. et al. Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/ visfatin linking obesity and inflammation in humans. Diabetologia 2011; 54: 1200-11.10.1007/s00125-010-2042-z
  60. 60. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C. et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 2003; 300: 472-6.10.1016/S0006-291X(02)02841-3
  61. 61. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C. et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 2003; 300: 472-6.10.1016/S0006-291X(02)02841-3
  62. 62. Nieva-Vazquez A, Pérez-Fuentes R, Torres-Rasgado E, López-López JG, Romero JR. Serum resistin levels are associated with adiposity and insulin sensitivity in obese Hispanic subjects. Metab Syndr Relat Disord 2014; 12: 143-8.10.1089/met.2013.0118399713924266722
  63. 63. Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV. et al. Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001; 50: 2199-202.10.2337/diabetes.50.10.219911574398
  64. 64. Sentinelli F, Romeo S, Arca M, Filippi E, Leonetti F, Banchieri M. et al. Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study. Diabetes 2002; 51: 860-2.10.2337/diabetes.51.3.86011872692
  65. 65. Azuma K, Oguchi S, Matsubara Y, Mamizuka T, Murata M, Kikuchi H. et al. Novel resistin promoter polymorphisms: association with serum resistin level in Japanese obese individuals. Horm Metab Res 2004; 36: 564-70.10.1055/s-2004-82576215326567
  66. 66. Ortega L, Riestra P, Navarro P, Gavela-Perez T, Soriano-Guillen L, Garces C. Resistin levels are related to fat mass, but not to body mass index in children. Peptides 2013; 49: 49-52.10.1016/j.peptides.2013.08.01924012666
  67. 67. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM. et al. The hormone resistin links obesity to diabetes. Nature 2001; 409: 307-12.10.1038/3505300011201732
  68. 68. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y. et al. Regulation of fasted blood glucose by resistin. Science 2004; 303: 1195-8.10.1126/science.109234114976316
  69. 69. Hivert MF, Sullivan LM, Fox CS, Nathan DM, D’Agostino RB, Sr., Wilson PW. et al. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance. J Clin Endocrinol Metab 2008; 93: 3165-72.10.1210/jc.2008-0425251508718492747
  70. 70. Geyikli I, Keskin M, Kor Y, Akan M. Increased resistin serum concentrations in patientswith type 1 diabetes mellitus. J Clin Res Pediatr Endocrinol 2013; 5: 189-93.10.4274/Jcrpe.1072381453424072088
  71. 71. Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H. et al. The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. Am J Hum Genet 2004; 75: 678-86.10.1086/424761118205515338456
  72. 72. Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun 2003; 309: 286-90.10.1016/j.bbrc.2003.07.00312951047
  73. 73. 73 gawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R. et al. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 2003; 88: 5452-5.10.1210/jc.2002-02180814602788
  74. 74. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM. et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005; 436: 356-62.10.1038/nature0371116034410
  75. 75. Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR. et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006; 354: 2552-63.10.1056/NEJMoa05486216775236
  76. 76. Janke J, Engeli S, Boschmann M, Adams F, Bohnke J, Luft FC. et al. Retinol-binding protein 4 in human obesity. Diabetes 2006; 55: 2805-10.10.2337/db06-061617003346
  77. 77. Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ. et al. Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone. J Clin Endocrinol Metab 2007; 92: 2590-7.10.1210/jc.2006-0816289341517595259
  78. 78. Ulgen F, Herder C, Kuhn MC, Willenberg HS, Schott M, Scherbaum WA. et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem 2010; 116: 57-62.10.3109/1381345100363142120222849
  79. 79. Bobbert T, Raila J, Schwarz F, Mai K, Henze A, Pfeiffer AF. et al. Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness. Atherosclerosis 2010; 213: 549-51.10.1016/j.atherosclerosis.2010.07.06320832065
  80. 80. Sasaki M, Otani T, Kawakami M, Ishikawa SE. Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction. Metabolism 2010; 59: 527-32.10.1016/j.metabol.2009.08.01519846170
  81. 81. Aeberli I, Biebinger R, Lehmann R, L’allemand D, Spinas GA, Zimmermann MB. Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children. J Clin Endocrinol Metab 2007; 92: 4359-65.10.1210/jc.2007-046817726085
  82. 82. Reinehr T, Stoffel-Wagner B, Roth CL. Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss. J Clin Endocrinol Metab 2008; 93: 2287-93.10.1210/jc.2007-2745272918118397979
  83. 83. Yeste D, Vendrell J, Tomasini R, Gallart LL, Clemente M, Simon I. et al. Retinol-binding protein 4 levels in obese children and adolescents with glucose intolerance. Horm Res Paediatr 2010; 73: 335-40.10.1159/00030816520389103
  84. 84. Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu FB. et al. Elevated retinolbinding protein 4 levels are associated with metabolic syndrome in Chinese people. J Clin Endocrinol Metab 2007; 92: 4827-34.10.1210/jc.2007-121917878249
  85. 85. Lim S, Yoon JW, Choi SH, Park YJ, Lee JJ, Park JH. et al. Combined impact of adiponectin and retinol-binding protein 4 on metabolic syndrome in elderly people: the Korean Longitudinal Study on Health and Aging. Obesity (Silver Spring) 2010; 18: 826-32.10.1038/oby.2009.23219661959
  86. 86. Wu Y, Li H, Loos RJ, Qi Q, Hu FB, Liu Y. et al. RBP4 variants are significantly associated with plasma RBP4 levels and hypertriglyceridemia risk in Chinese Hans. J Lipid Res 2009; 50: 1479-86.10.1194/jlr.P900014-JLR200269434619287041
  87. 87. Haider DG, Schindler K, Prager G, Bohdjalian A, Luger A, Wolzt M. et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 2007; 92: 1168-71.10.1210/jc.2006-183917164313
  88. 88. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab 2007; 92: 1971-4. 10.1210/jc.2006-271217341558
  89. 89. Promintzer M, Krebs M, Todoric J, Luger A, Bischof MG, Nowotny P. et al. Insulin resistance is unrelated to circulating retinol binding protein and protein C inhibitor. J Clin Endocrinol Metab 2007; 92: 4306-12.10.1210/jc.2006-252217726077
  90. 90. von EM, Lepper PM, Liu D, Lang K, Baumann M, Nawroth PP. et al. Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease. Diabetologia 2007; 50: 1930-7.10.1007/s00125-007-0743-817639305
  91. 91. Ribel-Madsen R, Friedrichsen M, Vaag A, Poulsen P. Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action. Diabetes 2009; 58: 54-60.10.2337/db08-1019260689318852328
  92. 92. Chavez AO, Coletta DK, Kamath S, Cromack DT, Monroy A, Folli F. et al. Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans. Am J Physiol Endocrinol Metab 2009; 296: E758-64.10.1152/ajpendo.90737.200819190263
  93. 93. Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010; 314: 1-16.10.1016/j.mce.2009.07.03119682539
  94. 94. Kotnik P, Keuper M, Wabitsch M, Fischer-Posovszky P. Interleukin-1beta downregulates RBP4 secretion in human adipocytes. PLoS One 2013; 8: e57796.10.1371/journal.pone.0057796358403623460908
  95. 95. Sell H, Eckel J. Regulation of retinol binding protein 4 production in primary human adipocytes by adiponectin, troglitazone and TNFalpha. Diabetologia 2007; 50: 2221-3.10.1007/s00125-007-0764-317661007
  96. 96. Cho YM, Youn BS, Lee H, Lee N, Min SS, Kwak SH. et al. Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes. Diabetes Care 2006; 29: 2457-61.10.2337/dc06-036017065684
  97. 97. Jia W, Wu H, Bao Y, Wang C, Lu J, Zhu J. et al. Association of serum retinol-binding protein 4 and visceral adiposity in Chinese subjects with and without type 2 diabetes. J Clin Endocrinol Metab 2007; 92: 3224-9.10.1210/jc.2007-020917550959
  98. 98. Kim IK, Lee HJ, Kang JH, Song J. Relationship of serum retinolbinding protein 4 with weight status and lipid profile among Korean children and adults. Eur J Clin Nutr 2011; 65: 226-33.10.1038/ejcn.2010.25121102613
  99. 99. Tan BK, Chen J, Lehnert H, Kennedy R, Randeva HS. Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids. J Clin Endocrinol Metab 2007; 92: 2764-72.10.1210/jc.2007-009117456573
  100. 100. Kos K, Wong S, Tan B, Kerrigan D, Randeva H, Pinkney J. et al. Human RBP4 adipose tissue expression is gender specific and influenced by leptin. Clin Endocrinol (Oxf) 2011; 74: 197-205.10.1111/j.1365-2265.2010.03892.x21039728
  101. 101. Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Schleicher E. et al. High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans. Diabetes Care 2007; 30: 1173-8.10.2337/dc06-234217259477
  102. 102. Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Retinol binding protein-4 levels and clinical features of type 2 diabetes patients. J Clin Endocrinol Metab 2007; 92: 2712-9.10.1210/jc.2006-124917440021
  103. 103. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H. et al. Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 2002; 51: 2734-41.10.2337/diabetes.51.9.273412196466
  104. 104. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, Heinze E. et al. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 2001; 25: 8-15.10.1038/sj.ijo.080152011244452
  105. 105. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD. et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007; 282: 28175-88.10.1074/jbc.M70079320017635925
  106. 106. Shin HY, Lee DC, Chu SH, Jeon JY, Lee MK, Im JA. et al. Chemerin levels are positively correlated with abdominal visceral fat accumulation. Clin Endocrinol (Oxf.) 2012; 77: 47-50.
  107. 107. Reyman M, Verrijn Stuart AA, van Summeren M, Rakhshandehroo M, Nuboer R, de Boer FK. et al. Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity. Int J Obes (Lond) 2014; 38: 46-52.10.1038/ijo.2013.7523736361
  108. 108. Chu SH, Lee MK, Ahn KY, Im JA, Park MS, Lee DC. et al. Chemerin and adiponectin contribute reciprocally to metabolic syndrome. PLoS One 2012; 7: e34710.10.1371/journal.pone.0034710332450422509348
  109. 109. Landgraf K, Friebe D, Ullrich T, Kratzsch J, Dittrich K, Herberth G. et al. Chemerin as a mediator between obesity and vascular inflammation in children. J Clin Endocrinol Metab 2012; 97: E556-64.10.1210/jc.2011-293722438234
DOI: https://doi.org/10.1515/sjph-2015-0020 | Journal eISSN: 1854-2476 | Journal ISSN: 0351-0026
Language: English
Page range: 131 - 138
Submitted on: Nov 6, 2014
Accepted on: Jan 14, 2015
Published on: Mar 13, 2015
Published by: National Institute of Public Health, Slovenia
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2015 Primož Kotnik, Pamela Fischer Posovszky, Martin Wabitsch, published by National Institute of Public Health, Slovenia
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.