Fifty-Five years of Pediatric Endocrinology and 50 years of the Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases in Slovenia / 55 Let Pediatrične Endokrinologije in 50 Let Kliničnega Oddelka Za Endokrinologijo, Diabetes in Presnovne Bolezni Pediatrične Klinike

Tadej Battelino

doi:10.1515/sjph-2015-0009

Abstract

Paediatric endocrinology started its independent development early in the general development of this specialty, with a strong focus on research and clinical excellence. Slovenian paediatric endocrinology was an integral part of the European paediatric endocrinology from its beginnings and a founding member of the first ‘International Study Group for Diabetes in Children and Adolescents’. After the pioneering work of Prof. Lev Matajc, Prof. Ciril Kržišnik firmly integrated the Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases at the University Children’s Hospital in Ljubljana in the international scientific community. In the last decade, the department participates in cutting-edge research and provides clinical services at highest international standards.

References

1. Matajc l, Brus L, Kržišnik C. et al. Health protection of diabetic children in Yugoslavia. Diab Croat 1978; 7: 65-8.
Search in Google Scholar
2. Kržišnik C. Forty years (1960-2000) of pediatric endocrinology in Slovenia. Slov Pediatr 2000; 7: 91-4.
Search in Google Scholar
3. Phillip M, Battelino T, Atlas E, Kordonouri O, Bratina N, Miller S.et al. Nocturnal glucose control with an artificial pancreas at a diabetes camp. N Engl J Med 2013; 368: 824-33.10.1056/NEJMoa120688123445093
Search in Google Scholar
4. de Schepper J, Rasmussen MH, Gucev Z, Eliakim A, Battelino T. Long-acting pegylated human GH in children with GH deficiency: a single-dose, dose-escalation trial investigating safety, tolerability, pharmacokinetics and pharmacodynamics. Eur J Endocrinol 2011; 165: 401-9.10.1530/EJE-11-053621724838
Search in Google Scholar
5. Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J. et al. Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia. J Clin Endocrinol Metab 2012; 97: E694-9.10.1210/jc.2011-2938331917822319038
Search in Google Scholar
6. Kotnik P, Keuper M, Wabitsch M, Fischer-Posovszky P. Interleukin-1β downregulates RBP4 secretion in human adipocytes. PLoS One 2013; 8: e57796.10.1371/journal.pone.0057796358403623460908
Search in Google Scholar
7. Sedej K, Kotnik P, Avbelj Stefanija M, Grošelj U, Širca Čampa A, Lusa L. et al. Decreased prevalence of hypercholesterolaemia and stabilisation of obesity trends in 5-year-old children: possible effects of changed public health policies. Eur J Endocrinol 2014; 170: 293-300.10.1530/EJE-13-056624225029
Search in Google Scholar
8. Groselj U, Murko S, Zerjav Tansek M, Kovac J, Trampus Bakija A, Repic Lampret B. et al. Comparison of tandem mass spectrometry and amino acid analyzer for phenylalanine and tyrosine monitoring-Implications for clinical management of patients with hyperphenylalaninemia. Clin Biochem 2015; 48: 14-8.10.1016/j.clinbiochem.2014.09.01425261586
Search in Google Scholar
9. Groselj U, Tansek MZ, Smon A, Angelkova N, Anton D, Baric I. et al. Newborn screening in southeastern Europe. Mol Genet Metab 2014; 113: 42-5.10.1016/j.ymgme.2014.07.02025174966
Search in Google Scholar
10. Dovc K, Telic SS, Lusa L, Bratanic N, Zerjav-Tansek M, Kotnik P. et al. Improved metabolic control in pediatric patients with type 1 diabetes: a nationwide prospective 12-year time trends analysis. Diabetes Technol Ther 2014; 16: 33-40.10.1089/dia.2013.0182388740424131373
Search in Google Scholar
11. Kovač J, Podkrajšek KT, Lukšič MM, Battelino T. Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder. Eur Child Adolesc Psychiatry 2015; 24: 75-82.10.1007/s00787-014-0537-824671236
Search in Google Scholar
12. Smigoc Schweiger D, Mendez A, Kunilo Jamnik S, Bratanic N, Bratina N, Battelino T. et al. Genetic risk for co-occurrence of type 1 diabetes and celiac disease is modified by HLA-C and killer immunoglobulinlike receptors. Tissue Antigens 2014; 84: 471-8.10.1111/tan.1245025329633
Search in Google Scholar
13. Hovnik T, Bratanič N, Podkrajšek KT, Kovač J, Paro D, Podnar T. et al.Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation. Eur J Pediatr 2013; 172: 1125-9.10.1007/s00431-012-1901-723229189
Search in Google Scholar
14. Tansek MZ, Groselj U, Murko S, Kobe H, Lampret BR, Battelino T. Assessment of tetrahydrobiopterin (BH(4))-responsiveness and spontaneous phenylalanine reduction in a phenylalanine hydroxylase deficiency population. Mol Genet Metab 2012; 107: 37-42.10.1016/j.ymgme.2012.07.01022917871
Search in Google Scholar
15. Groselj U, Tansek MZ, Kovac J, Hovnik T, Podkrajsek KT, Battelino T. Five novel mutations and two large deletions in a population analysis of the phenylalanine hydroxylase gene. Mol Genet Metab 2012; 106: 142-8.10.1016/j.ymgme.2012.03.01522513348
Search in Google Scholar
16. Kotnik P, Debeljak M, Avbelj M, Hovnik T, Ursic Bratina N, Krzisnik C. et al. Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto’s thyroiditis in young subjects with type 1 diabetes. Horm Res Paediatr 2010; 73: 244-7.10.1159/00028438820215770
Search in Google Scholar
17. Hovnik T, Dolzan V, Bratina NU, Podkrajsek KT, Battelino T. Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes. Diabetes Care 2009; 32: 2258-62.10.2337/dc09-0852278298719752172
Search in Google Scholar
18. Podkrajsek KT, Milenković T, Odink RJ, Claasen-van der Grinten HL, Bratanic N, Hovnik T. et al. Detection of a complete autoimmune regulator gene deletion and two additional novel mutations in a cohort of patients with atypical phenotypic variants of autoimmune polyglandular syndrome type 1. Eur J Endocrinol 2008; 159: 633-9.10.1530/EJE-08-032818682433
Search in Google Scholar
19. Cihakova D, Trebusak K, Heino M, Fadeyev V, Tiulpakov A, Battelino T. et al. Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED. Hum Mutat 2001; 18: 225-32.10.1002/humu.117811524733
Search in Google Scholar

Fifty-Five years of Pediatric Endocrinology and 50 years of the Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases in Slovenia / 55 Let Pediatrične Endokrinologije in 50 Let Kliničnega Oddelka Za Endokrinologijo, Diabetes in Presnovne Bolezni Pediatrične Klinike

Abstract

Paradigm

My account