The Impact of the Gene Variants FV Leiden, FII G20210A, MTHFR C677T and PAI-1 4G/5G on Pregnancy Loss in Women from Central Serbia
References
- 1 Mitić G, Považan L, Lazić R, Spasić D, Maticki-Sekulić M. Deficiency of the natural anticoagulantproteins in women with related venous thromboembolism. Med pregl. 2009; 62(1-2):53-62.
- 2 Stevens SM, Woller SC, Bauer KA, et al. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. Journal of Thrombosis and Thrombolysis. 2016; 41:154-164.
- 3 Versteeg HH, Heemskerk JW, Levi M, Reitsma PH. New fundamentals in hemostasis. Physiol Rev. 2013; 93(1):327-358.
- 4 Đorđević V, Rakićević LB, Spasić M, Miljić P, Miković D, Kovač M, et al. Factor V Leiden, FII G20210A, MTHFR C677T mutations as risk factors for venous thrombosis during pregnancy and puerperium. Vojnosanit pregl. 2005; 62(3):201-205.
- 5 Đorđević V, Gvozdenov M, Pruner I, Tomić B, Kovač M, Antonijević N, et al. The prevalence of PAI-1 4G/5G gene variant in Serbian population. Medicinski glasnik. 2013;18(49):28-41.
- 6 Đorđević V, Pruner I, Radojković D. Molecular basis of thrombophila. J Med Biochem 2014;33(1):22-7.
- 7 ClinVar [page on the internet]. Bethesda, U.S: National Center for Biotechnology Information National Library of Medicine, [Cited 2017 November]. Available from: https://www.ncbi.nlm.nih.gov/clinvar/
- 8 Sparić R, Lazović B, Stajić Z, Mazić S, Đelić M, Kadija S. Thromboembolic complications during pregnancy and delivery. Med pregl. 2013;66(9-10):417-423.
- 9 Simcox LE, Ormesher L, Tower C, Greer IA. Thrombophilia and Pregnancy Complications. Int J Mol Sci. 2015;16(12):28418-28428.
- 10 Husar D, Đelmiš J. Thrombophilia and its influence on the pregnancy outcome. Perinatol. 2008;17(3):150–156.
- 11 Mitić G, Novakov-Mikić A, Považan L, Mitreski A, Kopitović V, Vejnović T. Thromboprophylaxis implementation during pregnancy in women with recurrent fetal losses and thrombophilia. Med pregl. 2011; 64(9-10):471-475.
- 12 Ford HB, Schust DJ. Recurrent Pregnancy Loss: Etiology, Diagnosis, and Therapy. Reviews in Obstetrics and Gynecology. 2009; 2(2):76-83.
- 13 Mazzucconi MG, De Sanctis V, Alfò M, Amendolea MA, Conti L, Santoro C, Baldacci E, Peraino M, Masala C. Maternal thrombophilia and adverse pregnancy outcome: a case-control study. Acta Haematol. 2015;133(2):242-248.
- 14 Mitic G, Kovac M, Povazan L, Magic Z, Djordjevic V, Salatic I, Mitic I, Novakov-Mikic A. Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population. Clin Appl Thromb Hemost. 2010 Aug;16(4):435-9
- 15 Đorđević V, Pruner I, Rakičević L, Kovač M, Miković D, Miljić P, et al. FV Leiden, FII G20210A and MTHFR C677T mutations in patients with lower or upper limb deep vein thrombosis. Genetika. 2011;43(2):371-380.
- 16 Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY, editors. Williams Obstetrics. 23rd edition. United States of America: The McGraw-Hill Companies, Inc.2010.1385p.
- 17 Djordjevic V, Rakicevic LJ, Mikovic D, Kovac M, Miljic P, Radojkovic D, Savic A. Prevalence of factor V leiden, factor V cambridge, factor II G20210A and methylenetetrahydrofolate reductase C677T mutations in healthy and thrombophilic Serbian populations. Acta Haematol. 2004;112(4):227-229.
- 18 Kovac M, Mitic G, Mikovic Z, Djordjevic V, Savic O, Mandic V, Rakicevic LJ, Antonijevic N, Radojkovic D. Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Gynecol Obstet Invest. 2010;69(4):233-238.
- 19 Madjunkova S, Volk M, Peterlin B, Plaseska-Karanfilska D. Detection of Thrombophilic Mutations Related to Spontaneous Abortions by a Multiplex SNaPshot Method. Genetic Testing and Molecular Biomarkers. 2012;16(4):259-264.
- 20 Elezović I. Role of gene polymorphism in development of thromboses. Srp Arh Celok Lek. 2006;134 Suppl 1:64-71.
- 21 Isaoglu U, Ulug P, Delibas IB, Yilmaz M, Kumtepe Y, Dogan H, et al. The association between inherited thrombophilia and recurrent pregnancy loss in Turkish women. Clin Exp Obstet Gynecol. 2014;41(2):177-181.
- 22 Ocak Z, Özlü T, Ozyurt O. Association of recurrent pregnancy loss with chromosomal abnormalities and hereditary thrombophilias. African Health Sciences. 2013;13(2):447-452.
- 23 Khosravi F, Zarei S, Ahmadvand N, Akbarzadeh-Pasha Z, Savadi E, Zarnani AH, et al. Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure. J Assist Reprod Genet. 2014;31(1):121-124.
- 24 Shakarami F, Akbari MT, Zare Karizi S. Association of plasminogen activator inhibitor-1 and angiotensin converting enzyme polymorphisms with recurrent pregnancy loss in Iranian women. Iranian Journal of Reproductive Medicine. 2015;13(10):627-632.
- 25 Kurzawińska G, Barlik M, Drews K, Różycka A, Seremak-Mrozikiewicz A, Ożarowski M, Klejewski A, Czerny B, Wolski H. Coexistence of ACE (I/D) and PAI-1 (4G/5G) gene variants in recurrent miscarriage in Polish population. Ginekol Pol. 2016; 87(4):271-276.
- 26 Djordević V, Gvozdenović M, Pruner I, Mirjana Kovač M, Tomić B, Stanković M, Dragica Radojković D. The prevalence of PAI-1 4G/5G polymorphism in women with fetal loss-first data for a Serbian population J Med Biochem. 2014;33:203–207.
- 27 Liatsikos SA, Tsikouras P, Manav B, Csorba R, von Tempelhoff GF, Galazios G. Inherited thrombophilia and reproductive disorders. J Turk Ger Gynecol Assoc. 2016;17(1):45-50.
- 28 Li X, Liu Y, Zhang R, Tan J, Chen L, Liu Y. Meta-Analysis of the Association between Plasminogen Activator Inhibitor-1 4G/5G Polymorphism and Recurrent Pregnancy Loss. Med Sci Monit. 2015;21:1051-1056.
- 29 Dutra CG, Fraga LR, Nácul AP, Passos EP, Gonçalves RO, Nunes OL, De Godoy BA, Leistner-Segal S, Vianna FS, Schüler-Faccini L, Sanseverino MT. Lack of association between thrombophilic gene variants and recurrent pregnancy loss. Hum Fertil (Camb). 2014;17(2):99-105.
- 30 Wu X, Zhao L, Zhu H, He D, Tang W, Luo Y. Association between the MTHFR C677T polymorphism and recurrent pregnancy loss: a meta-analysis. Genet Test Mol Biomarkers. 2012;16(7):806-811.
- 31 Luo L, Chen Y, Wang L, et al. Polymorphisms of Genes Involved in the Folate Metabolic Pathway Impact the Occurrence of Unexplained Recurrent Pregnancy Loss. Reproductive Sciences. 2015;22(7):845-851.
- 32 Ivanov P, Gecheva S, Tsvyatkovska T, Izmailov A, Komsa-Penkova R, Kovacheva K, Konova E, Simeonova M, Tanchev S. A weak association of 677 C>T polymorphism in MTHFR with recurrent embryonic loss [Article in Bulgarian] Akush Ginekol (Sofiia). 2014;53(1):8-12.
- 33 Margetić S. Laboratory investigation of thrombophilia. J Med Biochem. 2014;33:28–46.
- 34 Ozdemir O, Yenicesu GI, Silan F, Köksal B, Atik S, Ozen F, Göl M, Cetin A. Recurrent pregnancy loss and its relation to combined parental thrombophilic gene mutations. Genet Test Mol Biomarkers. 2012;16(4):279-286.
Language: English
Page range: 19 - 25
Submitted on: Oct 13, 2017
Accepted on: Dec 14, 2017
Published on: Jun 5, 2020
Published by: University of Kragujevac, Faculty of Medical Sciences
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
Related subjects:
© 2020 Gordana M. Sosic, Snezana Sretenovic, Danijela Radivojevic, Nikola Jovic, Mirjana Varjacic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.