Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery

Jovanovic, Danijela; Milovanovic, Dragan R.; Jeremic, Nevena; Nikolic, Tamara; Stojic, Isidora; Jakovljevic, Vladimir; Vukovic, Natalija

doi:10.1515/sjecr-2017-0046

Abstract

Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.

The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1^st, 2^nd, 3^rd postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO₂⁻, H₂O₂, O₂⁻ ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.

QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H₂O₂ levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H₂O₂ from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O₂⁻, CAT) (p<0.05).

Women who underwent hysterectomy had significant changes of H₂O₂ and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.

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Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery

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