References
- 1. Jonasson, L., Holm, J., Skalli, O., Bondjers, G., & Hansson, G. K. (1986). Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis, Thrombosis, and Vascular Biology, 6(2), 131-138. doi:10.1161/01.atv.6.2.13110.1161/01.atv.6.2.131
- 2. Epstein, F. H., & Ross, R. (1999). Atherosclerosis — An Inflammatory Disease. New England Journal of Medicine, 340(2), 115-126. doi:10.1056/nejm19990114340020710.1056/NEJM199901143400207
- 3. Libby, P., Lichtman, A., & Hansson, G. (2013). Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans. Immunity, 38(6), 1092-1104. doi:10.1016/j.immuni.2013.06.009
- 4. Tuomisto, K., Jousilahti, P., Sundvall, J., Pajunen, P., & Salomaa, V. (2006). C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study. Thrombosis and Haemostasis. doi:10.1160/th05-08-057110.1160/TH05-08-0571
- 5. Breland, U. M., Michelsen, A. E., Skjelland, M., Folkersen, L., Krohg-Sørensen, K., Russell, D., Ueland, T., Yndestad, A., Paulsson-Berne, G., Damås, J.K., Oie, E., Hansson, G.K., Halvorsen, B., & Aukrust, P. (2010). Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation. Cardiovascular Research, 86(2), 265-273. doi:10.1093/cvr/cvq0442013911510.1093/cvr/cvq044
- 6. Martin-Ventura, J. L., Madrigal-Matute, J., Munoz- Garcia, B., Blanco-Colio, L. M., Oostrom, M. V., Zalba, G., Fortuño, A., Gomez-Guerrero, C., Ortega, L., Ortiy, A., Diey, J., & Egido, J. (2009). Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells. Cardiovascular Research, 83(3), 586-594. doi:10.1093/cvr/cvp14110.1093/cvr/cvp141
- 7. Szodoray, P., Timar, O., Veres, K., Der, H., Szomjak, E., Lakos, G., Aleksza, M., Nakken, B., Szegedi, G. & Soltesz, P. (2006). Th1/Th2 Imbalance, Measured by Circulating and Intracytoplasmic Inflammatory Cytokines – Immunological Alterations in Acute Coronary Syndrome and Stable Coronary Artery Disease. Scandinavian Journal of Immunology, 64(3), 336-344. doi:10.1111/j.1365-3083.2006.01816.x10.1111/j.1365-3083.2006.01816.x
- 8. Yamagami, H. (2005). Associations of Serum IL-18 Levels With Carotid Intima-Media Thickness. Arteriosclerosis, Thrombosis, and Vascular Biology, 25(7), 1458-1462. doi:10.1161/01.atv.0000168417.52486.56
- 9. Elkind, M. S., Rundek, T., Sciacca, R. R., Ramas, R., Chen, H., Boden-Albala, B., Rabbani, L., Sacco, R. L. (2005). Interleukin-2 levels are associated with carotid artery intima-media thickness. Atherosclerosis, 180(1), 181-187. doi:10.1016/j.atherosclerosis.2004.11.01510.1016/j.atherosclerosis.2004.11.015
- 10. Heeschen, C. (2003). Serum Level of the Antiinflammatory Cytokine Interleukin-10 Is an Important Prognostic Determinant in Patients With Acute Coronary Syndromes. Circulation, 107(16), 2109-2114. doi:10.1161/01.cir.0000065232.57371.25
- 11. Silveira, A., McLeod, O., Strawbridge, R. J., Gertow, K., Sennblad, B., Baldassarre, D., et al. (2015). Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis, 239(1), 125–130. doi.org/10.1016/j.atherosclerosis.2014.12.04610.1016/j.atherosclerosis.2014.12.046
- 12. Fiorentino, D. F. Bond MW, & Mosmann TB. (1989). Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. Journal of Experimental Medicine, 170(6), 2081-2095. doi:10.1084/jem.170.6.208110.1084/jem.170.6.2081
- 13. Malefyt, R. D. (1991). Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. Journal of Experimental Medicine, 174(5), 1209-1220. doi:10.1084/jem.174.5.1209
- 14. Mosser, D. M., & Zhang, X. (2008). Interleukin-10: new perspectives on an old cytokine. Immunological Reviews, 226(1), 205-218. doi:10.1111/j.1600-065x.2008.00706.x
- 15. Pestka, S., Krause, C.D., Sarkar, D., Walter, M.R., Shi, Y. & Fisher, P.B. (2004) Interleukin-10 and Related Cytokines and Receptors. Annual Review of Immunology, 22, 929-979.
- 16. Akdis, C. A. Joss A., Akdis M., Faith A. & Blaser K. A. (2000). A molecular basis for T cell suppression by IL- 10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding. The FASEB Journal. doi:10.1096/fj.99-0874fje
- 17. Opp, M., Smith, E., & Hughes, T. (1995). Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. Journal of Neuroimmunology, 60(1-2), 165-168. doi:10.1016/0165-5728(95)00066-b
- 18. Ma, X., Aste-Amezaga, M., Gri, G., Gerosa, F., & Trinchieri, G. (1997). Immunomodulatory Functions and Molecular Regulation of IL-12. Chemical Immunology and Allergy IL-12, 1-22. doi:10.1159/00005868710.1159/000058687
- 19. Varma, T. K., Toliver-Kinsky, T. E., Lin, C. Y., Koutrouvelis, A. P., Nichols, J. E., & Sherwood, E. R. (2001). Cellular Mechanisms That Cause Suppressed Gamma Interferon Secretion in Endotoxin-Tolerant Mice. Infection and Immunity, 69(9), 5249-5263. doi:10.1128/iai.69.9.5249-5263.200110.1128/IAI.69.9.5249-5263.2001
- 20. Mocellin, S. Panelli M.C., Wang E., Nagorsen D. & Marincola F.M. (2003). The dual role of IL-10. Trends in Immunology, 24(1), 36-43. doi:10.1016/s1471-4906(02)00009-1
- 21. Sikka, G., Miller, K. L., Steppan, J., Pandey, D., Jung, S. M., Fraser, C. D., et al. (2013). Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. Experimental Gerontology, 48(2), 128-135. doi:10.1016/j.exger.2012.11.001
- 22. Pinderski, L. J. (2002). Overexpression of Interleukin- 10 by Activated T Lymphocytes Inhibits Atherosclerosis in LDL Receptor-Deficient Mice by Altering Lymphocyte and Macrophage Phenotypes. Circulation Research, 90(10), 1064-1071. doi:10.1161/01.res.0000018941.10726.fa
- 23. Caligiuri, G., Rudling, M., Ollivier, V., Jacob, M.-P., Michel, J.-B., Hansson, G. K., & Nicoletti, A. (2003). Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice. Molecular Medicine, 9(1-2), 10–17.
- 24. Han, X., Kitamoto, S., Wang, H., & Boisvert, W. A. (2010). Interleukin-10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice. The FASEB Journal, 24(8), 2869-2880. doi:10.1096/fj.09-148155
- 25. Yoshioka, T., Okada, T., Maeda, Y., Ikeda, U., Shimpo, M., Nomoto, T. et al. (2004). Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice. Gene Therapy, 11(24), 1772-1779. doi:10.1038/sj.gt.3302348
- 26. Bancroft JD & Gamble M. (2002). Theory and practice of histological techniques. 5Thedition. Churchill Livingstone, Edeinburgh, London, New York, Oxford.
- 27. Stary H.C., Chandler A.B., Dinsmore R.E., Fuster V., Glagov S., Insull W. Jr, Rosenfeld M.E., Schwartz C.J., Wagner W.D. & Wissler R.W. (1995). A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis. A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation; 92: 1355-1374.
- 28. Moreno, P. R. (2010). Vulnerable Plaque: Definition, Diagnosis, and Treatment. Cardiology Clinics, 28(1), 1-30. doi:10.1016/j.ccl.2009.09.0081996204710.1016/j.ccl.2009.09.008
- 29. Shindo, A., Tanemura, H., Yata, K., Hamada, K., Shibata, M., Umeda, Y. et al. Tomimoto, H. (2014). Inflammatory Biomarkers in Atherosclerosis: Pentraxin 3 Can Become a Novel Marker of Plaque Vulnerability. PLoS ONE, 9(6). doi:10.1371/journal.pone.010004510.1371/journal.pone.0100045
- 30. Radosavljevic, G., Ljujic, B., Jovanovic, I., Srzentic, Z., Pavlovic, S., Zdravkovic, N., Milovanovic, M., Bankovic, D., Knezevic, M., Acimovic, LJ., & Arsenijevic, N. (2010). Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma. Neoplasma, 57(2), 135-144. doi:10.4149/neo_2010_02_13510.4149/neo_2010_02_135
- 31. Zhu, Y., Yang, H., Diao, Z., Li, Y., & Yan, C. (2015). Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study. Molecular Neurobiology, 53(4), 2698-2704. doi:10.1007/s12035-015-9368-y
- 32. Ambrosius, W., Kazmierski, R., Michalak, S., & Kozubski, W. (2006). Anti-inflammatory cytokines in subclinical carotid atherosclerosis. Neurology, 66(12), 1946-1948. doi:10.1212/01.wnl.0000219808.28678.4810.1212/01.wnl.0000219808.28678.48
- 33. Puz, P., & Lasek–Bal, A. (2017). Repeated measurements of serum concentrations of TNF-alpha, interleukin- 6 and interleukin-10 in the evaluation of internal carotid artery stenosis progression. Atherosclerosis, 263, 97-103. doi:10.1016/j.atherosclerosis.2017.06.008
- 34. Verma, S. K., Garikipati, V. N., Krishnamurthy, P., Khan, M., Thorne, T., Qin, G., Losordo, D. W. & Kishore, R. (2016). IL-10 Accelerates Re-Endothelialization and Inhibits Post-Injury Intimal Hyperplasia following Carotid Artery Denudation. Plos One, 11(1). doi:10.1371/journal.pone.0147615
- 35. Halvorsen, B., Wæhre, T., Scholz, H., Clausen, O. P., Thüsen, J. H., Müller, F., Heimli, H., Tonstad, S., Hall, C., Frøland, S.S., Biessen, E.A., Damås, J.K. & Aukrust, P. (2004). Interleukin-10 enhances the oxidized LDL-induced foam cell formation of macrophages by antiapoptotic mechanisms. Journal of Lipid Research, 46(2), 211-219. doi:10.1194/jlr.m400324-jlr200
- 36. Björkerud, S., & Björkerud, B. (1996). Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. The American Journal of Pathology, 149(2), 367–380.
- 37. Davies, M. J. (1996). Stability and Instability: Two Faces of Coronary Atherosclerosis: The Paul Dudley White Lecture 1995. Circulation, 94(8), 2013-2020. doi:10.1161/01.cir.94.8.2013
- 38. Libby, P. (1995). Molecular Bases of the Acute Coronary Syndromes. Circulation, 91(11), 2844-2850. doi:10.1161/01.cir.91.11.284410.1161/01.cir.91.11.2844
- 39. Han, X., & Boisvert, W. A. (2014). Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function. Thrombosis and Haemostasis, 113(3), 505-512. doi:10.1160/th14-06-0509
- 40. Chau, L., Lee, T., Yen, H., & Pan, C. (1998). Role of interleukin-12 in development of atherosclerosis in apoe-deficient mice. Atherosclerosis, 136. doi:10.1016/s0021-9150(97)84555-810.1016/S0021-9150(97)84555-8
- 41. Tits, L. V., Stienstra, R., Lent, P. V., Netea, M., Joosten, L., & Stalenhoef, A. (2011). Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2. Atherosclerosis, 214(2), 345-349. doi:10.1016/j.atherosclerosis.2010.11.01810.1016/j.atherosclerosis.2010.11.018
- 42. Du, L., Dronadula, N., Tanaka, S., & Dichek, D. A. (2011). Helper-Dependent Adenoviral Vector Achieves Prolonged, Stable Expression of Interleukin-10 in Rabbit Carotid Arteries but Does Not Limit Early Atherogenesis. Human Gene Therapy, 22(8), 959-968. doi:10.1089/hum.2010.17521198399
- 43. Kosmala, W., Derzhko, R., Przewlocka-Kosmala, M., Orda, A., & Mazurek, W. (2008). Plasma levels of TNF-α, IL-6, and IL-10 and their relationship with left ventricular diastolic function in patients with stable angina pectoris and preserved left ventricular systolic performance. Coronary Artery Disease, 19(6), 375-382. doi:10.1097/mca.0b013e3282fc617c
- 44. Zhang, D.-F., Song, X.-T., Chen, Y.-D., Yuan, F., Xu, F., Zhang, M., Zhang, M.-D., Wang, W., Dai, J & Lyu, S.- Z. (2016). Prognostic performance of interleukin-10 in patients with chest pain and mild to moderate coronary artery lesions—an 8-year follow-up study. Journal of Geriatric Cardiology : JGC, 13(3), 244–251. doi. org/10.11909/j.issn.1671-5411.2016.03.012
- 45. Fang, L., Moore, X.-L., Dart, A. M., & Wang, L.-M. (2015). Systemic inflammatory response following acute myocardial infarction. Journal of Geriatric Cardiology : JGC, 12(3), 305–312. doi.org/10.11909/j.issn.1671-5411.2015.03.02010.11909/j.issn.1671-5411.2015.03.020
- 46. Kozinski, M., Krzewina-Kowalska, A., Kubica, J., Żbikowska-Gotz, M., Dymek, G., Piasecki, R., Sukiennik, A., Grzesk, G., Bogdan, M., Chojnicki, M., Dziedziczko, A. & Sypniewska, G. (2005). Percutaneous coronary intervention triggers a systemic inflammatory response in patients treated for in-stent restenosis – comparison with stable and unstable angina. Inflammation Research, 54(5), 187-193. doi:10.1007/s00011-005-1342-010.1007/s00011-005-1342-0
- 47. Mallat, Z., Besnard, S., Duriez, M., Deleuze, V., Emmanuel, F., Bureau, M. F., et al. (1999). Protective Role of Interleukin-10 in Atherosclerosis. Circulation Research, 85(8). doi:10.1161/01.res.85.8.e17
- 48. Kimura T., Tse K., McArdle S., Gerhardt T., Miller J., Mikulski Z., Sidney J., Sette A., Wolf D., & Ley K. (2017)-Atheroprotective vaccination with MHC-II-re- -stricted ApoB peptides induces peritoneal IL-10-pro- -ducing CD4 T cells. Am J Physiol Heart Circ Physiol. Apr 1;312(4):H781-H790. doi: 10.1152/ajpheart.00798.- 2016. Epub 2017 Jan 13. PubMed PMID:28087520; PubMed Central PMCID: PMC5407161.