Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

Jeremic, Nevena; Zivkovic, Vladimir; Srejovic, Ivan; Jeremic, Jovana; Petkovic, Anica; Bradic, Jovana; Jakovljevic, Vladimir

doi:10.1515/sjecr-2017-0008

Abstract

Aim of present study was to determine the participation of various biomarkers of oxidative damage: nitrite (NO₂⁻), superoxide anion radicals (O₂⁻), index of lipid peroxidation (TBARS) and hydrogen peroxide (H₂O₂) in coronary circulation after application of the different models of preconditioning such as ischemic and preconditioning with proton pump inhibitors.

Examining a biochemical markers of oxidative damage we did not notice any increased production values of any parameter, according to that we can hypothesize that possible occurrence of reperfusion injury after ischemia and PPIs preconditioning is not mediated by this mechanism.

Due to the very difficult and controversial application of ischemic preconditioning in clinical practice, the results of this study suggest that in the future proton pump inhibitors can contribute to the prevention of myocardial damage following ischemia

References

1. Przyklenk, K., & Kloner, R. A. (1998). Ischemic preconditioning: exploring the paradox. Prog Cardiovasc Dis, 40(6), 517-547.10.1016/S0033-0620(98)80002-9
Open DOI Search in Google Scholar Back to article
2. Ara, J., Fekete, S., Frank, M., Golden, J. A., Pleasure, D., & Valencia, I. (2011). Hypoxic-preconditioning induces neuroprotection against hypoxia-ischemia in newborn piglet brain. Neurobiol Dis, 43(2), 473-485.10.1016/j.nbd.2011.04.021
Open DOI Search in Google Scholar Back to article
3. Cantagrel, S., Krier, C., Ducrocq, S., Bodard, S., Payen, V., Laugier, J., Chalon, S. (2003). Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia. Neurosci Lett, 347(2), 106-110.10.1016/S0304-3940(03)00525-1
Search in Google Scholar Back to article
4. Altug, S., Demiryurek, A. T., Kane, K. A., & Kanzik, I. (2000). Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts. Br J Pharmacol, 130(1), 125-131.10.1038/sj.bjp.0703280
Search in Google Scholar Back to article
5. Verma, S., Maitland, A., Weisel, R. D., Li, S. H., Fedak, P. W., Pomroy, N. C., Rao, V. (2002). Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. J Thorac Cardiovasc Surg, 123(6), 1120-1124.10.1067/mtc.2002.121973
Search in Google Scholar Back to article
6. Yellon, D. M., & Hausenloy, D. J. (2007). Myocardial reperfusion injury. N Engl J Med, 357(11), 1121-1135.10.1056/NEJMra071667
Search in Google Scholar Back to article
7. Gomes, O. M., Magalhaes Mde, M., & Abrantes, R. D. (2010). Myocardium functional recovery protection by omeprazole after ischemia-reperfusion in isolated rat hearts. Rev Bras Cir Cardiovasc, 25(3), 388-392.10.1590/S0102-76382010000300016
Search in Google Scholar Back to article
8. Gomes, O. M., Magalhaes Mde, M., Abrantes, R. D., & Kallas, E. (2011). Pantoprazole provides myocardial protection similar to ischemic preconditioning: experimental study of isolated hearts of rats. Rev Bras Cir Cardiovasc, 26(3), 433-439.10.5935/1678-9741.20110019
Search in Google Scholar Back to article
9. Jeremic, N., Petkovic, A., Srejovic, I., Zivkovic, V., Djuric, D., & Jakovljevic, V. (2015). Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart. Rev Bras Cir Cardiovasc, 30(2), 266-275.10.5935/1678-9741.20150020
Search in Google Scholar Back to article
10. Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95(2), 351-358.10.1016/0003-2697(79)90738-3
Search in Google Scholar Back to article
11. Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982). Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem, 126(1), 131-138.10.1016/0003-2697(82)90118-X
Search in Google Scholar Back to article
12. C Auclair, E Voisin. (1985). Nitroblue tetrazolium reduction Vol. 123. Handbook of methods for oxygen radical research (pp. 123–132).
Search in Google Scholar Back to article
13. Pick, E., & Keisari, Y. (1980). A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Methods, 38(1-2), 161-170.10.1016/0022-1759(80)90340-3
Open DOI Search in Google Scholar Back to article
14. Goswami, S. K., Maulik, N., & Das, D. K. (2007). Ischemia-reperfusion and cardioprotection: a delicate balance between reactive oxygen species generation and redox homeostasis. Ann Med, 39(4), 275-289.10.1080/0785389070137467717558599
Open DOI Search in Google Scholar Back to article
15. Kurzelewski, M., Czarnowska, E., & Beresewicz, A. (2005). Superoxide- and nitric oxide-derived species mediate endothelial dysfunction, endothelial glycocalyx disruption, and enhanced neutrophil adhesion in the post-ischemic guinea-pig heart. J Physiol Pharmacol, 56(2), 163-178.
Search in Google Scholar Back to article
16. Raedschelders, K., Ansley, D. M., & Chen, D. D. (2012). The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther, 133(2), 230-255.10.1016/j.pharmthera.2011.11.00422138603
Search in Google Scholar Back to article
17. Nonami, Y. (1997). The role of nitric oxide in cardiac ischemia-reperfusion injury. Jpn Circ J, 61(2), 119-132.10.1253/jcj.61.1199070967
Open DOI Search in Google Scholar Back to article
18. Hess, M. L., & Manson, N. H. (1984). Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol, 16(11), 969-985.
Search in Google Scholar Back to article
19. Pagliaro, P., & Penna, C. (2015). Redox signalling and cardioprotection: translatability and mechanism. Br J Pharmacol, 172(8), 1974-1995.10.1111/bph.12975438697625303224
Search in Google Scholar Back to article
20. Wandall, J. H. (1992). Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245. Gut, 33(5), 617-621.10.1136/gut.33.5.61713792891319381
Search in Google Scholar Back to article
21. Hackert, T., Tudor, S., Felix, K., Dovshanskiy, D., Hartwig, W., Simon, W. A., & Werner, J. (2010). Effects of pantoprazole in experimental acute pancreatitis. Life Sci, 87(17-18), 551-557.10.1016/j.lfs.2010.09.00820851132
Search in Google Scholar Back to article
22. Simon, W. A., Sturm, E., Hartmann, H. J., & Weser, U. (2006). Hydroxyl radical scavenging reactivity of proton pump inhibitors. Biochem Pharmacol, 71(9), 1337-1341.10.1016/j.bcp.2006.01.00916494850
Search in Google Scholar Back to article
23. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I., Varadaraj, A., Ali, E., & Banerjee, R. K. (2003). A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem, 278(13), 10993-11001.10.1074/jbc.M21032820012529378
Search in Google Scholar Back to article
24. Gozal, Y., Chevion, M., Elami, A., Berenshtein, E., Kitrossky, N., & Drenger, B. (2005). Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion. Eur J Anaesthesiol, 22(1), 49-55.10.1017/S0265021505000116
Search in Google Scholar Back to article
25. Doucet, A. (1997). H+, K(+)-ATPASE in the kidney: localization and function in the nephron. Exp Nephrol, 5(4), 271-276.
Search in Google Scholar Back to article
26. Hayashi, H., Shimamoto, K., Taniai, E., Ishii, Y., Morita, R., Suzuki, K., Mitsumori, K. (2012). Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action. J Toxicol Sci, 37(3), 491-501.10.2131/jts.37.49122687989
Open DOI Search in Google Scholar Back to article
27. Petronilho, F., Araujo, J. H., Steckert, A. V., Rezin, G. T., Ferreira, G. K., Roesler, R., Streck, E. L. (2009). Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis. Peptides, 30(8), 1460-1465.10.1016/j.peptides.2009.04.02619505518
Search in Google Scholar Back to article

Effects of Ischemic and Proton Pump Inhibitors Preconditioning on Oxidative Stress of Isolated Rat Heart

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