Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid

Dusan Lj. Tomovic; Andriana M. Bukonjic; Aleksandar Kocovic; Milos V. Nikolic; Marina Z. Mijajlovic; Verica V. Jevtic; Zoran R. Ratkovic; Aleksandar N. Arsenijevic; Jelena Z. Milovanovic; Bojana Stojanovic; Srecko R. Trifunovic; Gordana P. Radic

doi:10.1515/sjecr-2016-0071

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Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid

EABR. Experimental and Applied Biomedical Research

Volume 18 (2017): Issue 1 (March 2017)

By: Dusan Lj. Tomovic, Andriana M. Bukonjic, Aleksandar Kocovic, Milos V. Nikolic, Marina Z. Mijajlovic, Verica V. Jevtic, Zoran R. Ratkovic, Aleksandar N. Arsenijevic, Jelena Z. Milovanovic, Bojana Stojanovic, Srecko R. Trifunovic and Gordana P. Radic

Open Access

|Mar 2017

Abstract

New complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (alkenyl = propenyl-(L1), isobutenyl-(L2)) have been synthesized and characterized by microanalysis, infrared spectra, magnetic measurements, and by NMR spectra. The cytotoxic activity of two newly synthesized precursor S-alkenyl derivatives of thiosalicylic acid were tested using an MTT colorimetric technique on HCT-116 human colon carcinoma cells. The cytotoxic effect of the copper(II)- complexes were higher compared to the cytotoxicity of the corresponding ligand (for concentrations from 31.25 to 250 μM). Copper(II)-complexes showed a slightly lower cytotoxicity compared to cisplatin. Complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (at concentrations from 250 to 1000 μM) had a cytotoxic effect on HCT-116 cells compared to cisplatin.

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Articles in this issue

DOI: https://doi.org/10.1515/sjecr-2016-0071 | Journal eISSN: 2956-2090 | Journal ISSN: 2956-0454

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Language: English

Page range: 13 - 18

Submitted on: Jul 12, 2016

Accepted on: Jul 25, 2016

Published on: Mar 16, 2017

Published by: University of Kragujevac, Faculty of Medical Sciences

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

S-alkenyl derivatives of thiosalicylic acid,

copper(II)-complexes,

IR and NMR spectroscopy,

cytotoxic activity

Related subjects:

Medicine,

Clinical medicine,

Clinical medicine, other

© 2017 Dusan Lj. Tomovic, Andriana M. Bukonjic, Aleksandar Kocovic, Milos V. Nikolic, Marina Z. Mijajlovic, Verica V. Jevtic, Zoran R. Ratkovic, Aleksandar N. Arsenijevic, Jelena Z. Milovanovic, Bojana Stojanovic, Srecko R. Trifunovic, Gordana P. Radic, published by University of Kragujevac, Faculty of Medical Sciences
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 18 (2017): Issue 1 (March 2017)