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Nature or Nurture – Will Epigenomics Solve the Dilemma?

Open Access
|Sep 2016

References

  1. 1. Akbarian, S., Halene, T. The neuroepigenetics of suicide. The American Journal of Psychiatry 170(5), 2013, pp. 462-465.10.1176/appi.ajp.2013.13020235405556723632831
  2. 2. Aksoy-Aksel, A., Zampa, F., Schratt, G. MicroRNAs and synaptic plasticity--a mutual relationship. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0515414203625135976
  3. 3. Alexander, R. P., Fang, G., Rozowsky, J., Snyder, M., Gerstein, M. B. Annotating non-coding regions of the genome. Nature Reviews. Genetics 11(8), 2010, pp. 559-571.10.1038/nrg281420628352
  4. 4. Anthoni, H., Zucchelli, M., Matsson, H., Müller-Myhsok, B., Fransson, I., Schumacher, J., Massinen, S., Onkamo, P., Warnke, A., Griesemann, H., Hoffmann, P., Nopola-Hemmi, J., Lyytinen, H., Schulte-Körne, G., Kere, J., Nöthen, M. M., Peyrard-Janvid, M. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. Human Molecular Genetics 16(6), 2007, pp. 667-677.10.1093/hmg/ddm00917309879
  5. 5. Anway, M. D., Cupp, A. S., Uzumcu, M., Skinner, M. K. Epigenetic trans-generational actions of endocrine disruptors and male fertility. Science 308, 2005, pp. 1466-1469.10.1126/science.110819015933200
  6. 6. Arai, J. A., Li, S., Hartley, D. M., Feig, L. A. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. Journal of Neuroscience 29, 2009, pp. 1496-1502.10.1523/JNEUROSCI.5057-08.2009340823519193896
  7. 7. Bale, T. L. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues in Clinical Neuroscience 16(3), 2014, pp. 297-305.10.31887/DCNS.2014.16.3/tbale
  8. 8. Barker, D., Barker, M., Fleming, T., Lampl, M. Developmental biology: Support mothers to secure future public health. Nature 504(7479), 2013, pp. 209-211.
  9. 9. Barry, G. Lamarckian evolution explains human brain evolution and psychiatric disorders. Frontiers in Neuroscience 7, 2013, pp. 224.10.3389/fnins.2013.00224384050424324395
  10. 10. Berger, S., Pérez-Rodríguez, P., Veturi, Y., Simianer, H., de los Campos, G.. Effectiveness of shrinkage and variable selection methods for the prediction of complex human traits using data from distantly related individuals. Annals of Human Genetics 79(2), 2015, pp. 122-135.10.1111/ahg.12099442815525600682
  11. 11. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes, M., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the lactase gene. American Journal of Human Genetics 74(6), 2004, pp. 1111-1120.10.1086/421051118207515114531
  12. 12. Blaxter, M. Genetics. Revealing the dark matter of the genome. Science 330(6012), 2010, pp. 1758-1759.
  13. 13. Bohacek, J., Gapp, K., Saab, B. J., Mansuy, I. M. Transgenerational epigenetic effects on brain functions. Biological Psychiatry 73(4), 2013, pp. 313-320.10.1016/j.biopsych.2012.08.01923062885
  14. 14. Bowers, M. E., Yehuda, R. Intergenerational transmission of stress in humans. Neuropsychopharmacology 41(1), 2016, pp. 232-244.10.1038/npp.2015.247467713826279078
  15. 15. Bromer, J. G., Wu, J., Zhou, Y., Taylor, H. S. Hypermethylation of Homeobox A10 by in utero diethylstilbestrol exposure: An epigenetic mechanism for altered developmental programming. Endocrinology 150, 2009, pp. 3376-3382.10.1210/en.2009-0071270350819299448
  16. 16. Burggren, W. W. Epigenetics as a source of variation in comparative animal physiology - or - Lamarck is lookin' pretty good these days. The Journal of Experimental Biology 217(Pt 5), 2014, pp. 682-689.10.1242/jeb.08613224574384
  17. 17. Burggren, W. W., Crews, D. Epigenetics in comparative biology: why we should pay attention. Integrative and Comparative Biology 54(1), 2014, pp. 7-20.10.1093/icb/icu013413357224722321
  18. 18. Button, T. M., Lau, J. Y., Maughan, B., Eley, T. C. Parental punitive discipline, negative life events and gene-environment interplay in the development of externalizing behavior. Psychological Medicine 38(1), 2008, pp. 29-39.10.1017/S0033291707001328290639817803832
  19. 19. Cacabelos, R., Torrellas C. Epigenetics of aging and Alzheimer's disease: Implications for pharmacogenomics and drug response. International Journal of Molecular Sciences 16(12), 2015, pp. 30483-30543.10.3390/ijms161226236469117726703582
  20. 20. Cao-Lei, L., Elgbeili, G., Massart, R., Laplante, D. P., Szyf, M., King, S. Pregnant women's cognitive appraisal of a natural disaster affects DNA methylation in their children 13 years later: Project Ice Storm. Translational Psychiatry 5, 2015, p. e515.10.1038/tp.2015.13444575025710121
  21. 21. Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Shaw, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., Ziaugra, L., Friedland, L., Rolfe, A., Warrington, J., Lipshutz, R., Daley, G. Q., Lander, E. S. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genetics 22(3), 1999, pp. 231-238. Erratum in: Nature Genetics 23(3), 1999, p. 373.10.1038/1029010391209
  22. 22. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., Poulton, R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 2003, pp. 386-389.10.1126/science.108396812869766
  23. 23. Chabris, C. F., Hebert, B. M., Benjamin, D. J., Beauchamp, J., Cesarini, D., van der Loos, M., Johannesson, M., Magnusson, P. K., Lichtenstein, P., Atwood, C. S., Freese, J., Hauser, T. S., Hauser, R. M., Christakis, N., Laibson, D. Most reported genetic associations with general intelligence are probably false positives. Psychological Science 23(11), 2012, pp. 1314-23.10.1177/0956797611435528349858523012269
  24. 24. Chen, C., Meng, S. Q., Xue, Y. X., Han, Y., Sun, C. Y., Deng, J. H., Chen, N., Bao, Y. P., Zhang, F. L., Cao, L. L., Zhu, W. G., Shi, J., Song, W. H., Lu, L. Epigenetic modification of PKMζ rescues aging-related cognitive impairment. Scientific Reports 6, 2016, p. 22096.10.1038/srep22096477200326926225
  25. 25. Chong, S., Whitelaw, E. Epigenetic germline inheritance. Current Opinion in Genetics & Development 14, 2004, pp. 692-696.10.1016/j.gde.2004.09.00115531166
  26. 26. Clarke, A.J., Cooper, D.N., GWAS: heritability missing in action? European Journal of Human Genetics 18, 2010, pp. 859-861.10.1038/ejhg.2010.35298738920234388
  27. 27. Conrad, D. F., Pinto, D., Redon, R., Feuk, L., Gokcumen, O., Zhang, Y., Aerts, J., Andrews, T. D., Barnes, C., Campbell, P., Fitzgerald, T., Hu, M., Ihm, C. H., Kristiansson, K., Macarthur, D. G., Macdonald, J. R., Onyiah, I., Pang, A. W., Robson, S., Stirrups, K., Valsesia, A., Walter, K., Wei, J., Wellcome Trust Case Control Consortium, Tyler-Smith, C., Carter, N. P., Lee, C., Scherer, S. W., Hurles, M. E. Origins and functional impact of copy number variation in the human genome. Nature 464(7289), 2010, pp. 704-712.
  28. 28. Cortés-Mendoza, J., Díaz de León-Guerrero, S., Pedraza-Alva, G., Pérez-Martínez, L. Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription. International Journal of Developmental Neuroscience 31(6), 2013, pp. 359-69.10.1016/j.ijdevneu.2013.04.00323665156
  29. 29. Crews, D., Gillette, R., Scarpino, S. V., Manikkam, M., Savenkova, M. I., Skinner, M. K. Epigenetic transgenerational inheritance of altered stress responses. Proceedings of the National Academy of Sciences of the United States of America 109, 2012, pp. 9143-9148. 10.1073/pnas.1118514109338416322615374
  30. 30. Curley, J. P., Champagne, F.A. Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods. Frontiers in Neuroendocrinology 40, 2016, pp. 52-66.10.1016/j.yfrne.2015.11.001478328426616341
  31. 31. Dawson, M. A., Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150(1), 2012, pp. 12-27.10.1016/j.cell.2012.06.01322770212
  32. 32. Daxinger, L., Whitelaw, E. Transgenerational epigenetic inheritance: More questions than answers. Genome Research 20, 2010, pp. 1623-1628.10.1101/gr.106138.110298998821041414
  33. 33. Daxinger, L., Whitelaw, E. Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nature Reviews Genetics 13, 2012, pp. 153-162.10.1038/nrg318822290458
  34. 34. de los Campos, G., Vazquez, A. I., Fernando, R., Klimentidis, Y. C., Sorensen, D. Prediction of complex human traits using the genomic best linear unbiased predictor. PLoS Genetics 9(7), 2013, p. e1003608.10.1371/journal.pgen.1003608370884023874214
  35. 35. Desrivières, S., Lourdusamy, A., Tao, C., Toro, R., Jia, T., Loth, E., Medina, L. M., Kepa, A., Fernandes, A., Ruggeri, B., Carvalho, F. M., Cocks, G., Banaschewski, T., Barker, G. J., Bokde, A. L., Büchel, C., Conrod, P. J., Flor, H., Heinz, A., Gallinat, J., Garavan, H., Gowland, P., Brühl, R., Lawrence, C., Mann, K., Martinot, M. L., Nees, F., Lathrop, M., Poline, J. B., Rietschel, M., Thompson, P., Fauth-Bühler, M., Smolka, M. N., Pausova, Z., Paus, T., Feng, J., Schumann, G. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular Psychiatry 20(2), 2014, pp. 263-274.10.1038/mp.2013.197405159224514566
  36. 36. Devanna, P., Middelbeek, J., Vernes, S. C. FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways. Frontiers in Cellular Neuroscience 8, 2014, p. 305.10.3389/fncel.2014.00305417645725309332
  37. 37. Dias, B. G., Maddox, S. A., Klengel, T., Ressler, K. J. Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends in Neuroscience 38(2), 2015, pp. 96-107.10.1016/j.tins.2014.12.003432386525544352
  38. 38. Dias, B. G., Ressler, K. J. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience 17(1), 2014, pp. 89-96.10.1038/nn.3594392383524292232
  39. 39. Dick, D. M., Agrawal, A., Keller, M. C., Adkins, A., Aliev, F., Monroe, S., Hewitt, J. K., Kendler, K. S., Sher, K. J. Candidate gene-environment interaction research: reflections and recommendations. Perspectives on Psychological Science: A Journal of the Association for Psychological Science 10(1), 2015, pp. 37-59.
  40. 40. Dick, D. M., Bernard, M., Aliev, F., Viken, R., Pulkkinen, L., Kaprio, J., Rose, R. J. The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. Alcoholism: Clinical and Experimental Research 33(10), 2009, pp. 1739-1748.10.1111/j.1530-0277.2009.01011.x359484619624574
  41. 41. Dietz, D. M., LaPlant, Q., Watts, E. L., Hodes, G. E., Russo, S. J., Feng, J., Oosting, R. S., Vialou, V., Nestler, E. J. Paternal transmission of stress-induced pathologies. Biological Psychiatry 70, 2011, pp. 408-414.10.1016/j.biopsych.2011.05.005321719721679926
  42. 42. Drong, A. W., Lindgren, C. M., McCarthy, M. I. The genetic and epigenetic basis of type 2 diabetes and obesity. Clinical Pharmacology and Therapeutics 92(6), 2012, pp. 707-15.10.1038/clpt.2012.149711674723047653
  43. 43. Duncan, L. E., Keller, M. C. A critical review of the first 10 years of candidate gene-byenvironment interaction research in psychiatry. American Journal of Psychiatry 168, 2011, pp. 1041-1049.10.1176/appi.ajp.2011.11020191322223421890791
  44. 44. Egger, G., Liang, G., Aparicio, A., Jones, P. A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429(6990), 2004, pp. 457-463.
  45. 45. Ehrlich, M., Lacey, M. DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics 5, 2013, pp. 553-568.10.2217/epi.13.43386489824059801
  46. 46. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Järvelä, I. Identification of a variant associated with adult-type hypolactasia. Nature Genetics 30(2), 2002, pp. 233-237.10.1038/ng82611788828
  47. 47. Enattah, N. S., Jensen, T. G., Nielsen, M., Lewinski, R., Kuokkanen, M., Rasinpera, H., El- Shanti, H., Seo, J. K., Alifrangis, M., Khalil, I. F., Natah, A., Ali, A., Natah, S., Comas, D., Mehdi, S. Q., Groop, L., Vestergaard, E. M., Imtiaz, F., Rashed, M. S., Meyer, B., Troelsen, J., Peltonen, L. Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. American Journal of Human Genetics 82(1), 2008, pp. 57-72.10.1016/j.ajhg.2007.09.012225396218179885
  48. 48. English, A. C., Salerno, W. J., Hampton, O. A., Gonzaga-Jauregui, C., Ambreth, S., Ritter, D. I., Beck, C. R., Davis, C. F., Dahdouli, M., Ma, S., Carroll, A., Veeraraghavan, N., Bruestle, J., Drees, B., Hastie, A., Lam, E. T., White, S., Mishra, P., Wang, M., Han, Y., Zhang, F., Stankiewicz, P., Wheeler, D. A., Reid, J. G., Muzny, D. M., Rogers, J., Sabo, A., Worley, K. C., Lupski, J. R., Boerwinkle, E., Gibbs, R. A. Assessing structural variation in a personal genome-towards a human reference diploid genome. BMC Genomics 16, 2015, p. 286.10.1186/s12864-015-1479-3449061425886820
  49. 49. Fagiolini, M., Jensen, C. L., Champagne, F. A. Epigenetic influences on brain development and plasticity. Current Opinion in Neurobiology 19(2), 2009, pp. 207-212.10.1016/j.conb.2009.05.009274559719545993
  50. 50. Fass, D. M., Schroeder, F. A., Perlis, R. H., Haggarty, S. J. Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience 264, 2014, pp. 112-130.10.1016/j.neuroscience.2013.01.041383072123376737
  51. 51. Federman, N., Zalcman, G., de la Fuente, V., Fustiñana, M. S., Romano, A. Epigenetic mechanisms and memory strength: a comparative study. Journal of Physiology, Paris 108(4-6), 2014, pp. 278-85.10.1016/j.jphysparis.2014.06.00324978317
  52. 52. Feil, R., Fraga, M. Epigenetics and the environment: Emerging patterns and implications. Nature Review Genetics 13(2), 2012, pp. 97-109.10.1038/nrg314222215131
  53. 53. Feuk, L., Carson, A. R., Scherer, S. W. Structural variation in the human genome. Nature Reviews. Genetics 7(2), 2006, pp. 85-97.10.1038/nrg176716418744
  54. 54. Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M., Tsai, L. H. Recovery of learning and memory is associated with chromatin remodeling. Nature 447(7141), 2007, pp. 178-82.
  55. 55. Fisher, S.E. Tangled webs: tracing the connections between genes and cognition. Cognition. 101(2), 2006, pp. 270-97.10.1016/j.cognition.2006.04.00416764847
  56. 56. Fisher, S. E., Scharff, C. FOXP2 as a molecular window into speech and language. Trends in Genetics 25, 2009, pp. 166-177.10.1016/j.tig.2009.03.00219304338
  57. 57. Fisher, S. E., Vargha-Khadem, F., Watkins, K. E., Monaco, A. P., Pembrey, M. E. Localisation of a gene implicated in a severe speech and language disorder. Nature Genetics 18(2), 1998, pp. 168-170.10.1038/ng0298-1689462748
  58. 58. Flynn, J. R. The mean IQ of Americans: Massive gains 1932 to 1978. Psychological Bulletin 95, 1984, pp. 29-51.10.1037/0033-2909.95.1.29
  59. 59. Fox-Keller, E. The mirage of a space between nature and nurture. Duke University Press: Durham, NC and London, 2010.10.1515/9780822392811
  60. 60. Fraga, M. F., Ballesta, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., Boix-Chornet, M., Sanchez-Aguilera, A., Ling, C., Carlsson, E., Poulsen, P., Vaag, A., Stephan, Z., Spector, T. D., Wu, Y. Z., Plass, C., Esteller, M. Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences of the United States of America 102(30), 2005, pp. 10604-10609.10.1073/pnas.0500398102117491916009939
  61. 61. Franklin, T. B., Russig, H., Weiss, I. C., Graff, J., Linder, N., Michalon, A. Epigenetic transmission of the impact of early stress across generations. Biological Psychiatry 68, 2010, pp. 408-415.10.1016/j.biopsych.2010.05.03620673872
  62. 62. Fu, L., Shi, Z., Luo, G., Tu, W., Wang, X., Fang, Z., Li, X. Multiple microRNAs regulate human FOXP2 gene expression by targeting sequences in its 3' untranslated region. Molecular Brain 7, 2014, p. 71.10.1186/s13041-014-0071-0418959125269856
  63. 63. Fullard, J. F., Halene, T. B., Giambartolomei, C., Haroutunian, V., Akbarian, S., Roussos, P. Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophrenia Research Jan 27, 2016, pp. S0920-9964(16)30039-1.10.1016/j.schres.2016.01.039496330626827128
  64. 64. Galton, F. On men of science, their nature and nurture. In. Notices of the proceedings at the meetings of the members of the Royal Institution of Great Britain. Vol. VII. 1873-1875, William Clowes and Sons: London, 1875.
  65. 65. Gamazon, E. R., Stranger, B. E. The impact of human copy number variation on gene expression. Briefings in Functional Genomics 14(5), 2015, pp. 352-357.10.1093/bfgp/elv017459235425922366
  66. 66. Gao, M. C., Bellugi, U., Dai, L., Mills, D. L., Sobel, E. M., Lange, K., Korenberg, J. R. Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex. PLoS ONE 5(4), 2010, p. e10292.10.1371/journal.pone.0010292285821220422020
  67. 67. Gapp, K., Bohacek, J., Grossmann, J., Brunner, A. M., Manuella, F., Nanni, P., Mansuy, I. M. Potential of environmental enrichment to prevent transgenerational effects of paternal trauma. Neuropsychopharmacology Jun 9, 2016.10.1038/npp.2016.87502674427277118
  68. 68. Gerstein, M. B., Bruce, C., Rozowsky, J. S., Zheng, D., Du, J., Korbel, J. O., Emanuelsson, O., Zhang, Z. D., Weissman, S., Snyder M. What is a gene, post-ENCODE? History and updated definition. Genome Research 17(6), 2007, pp. 669-681.10.1101/gr.633960717567988
  69. 69. Glinsky, G. V. Phenotype-defining functions of multiple non-coding RNA pathways. Cell Cycle 7(11), 2008, pp. 1630-1639.10.4161/cc.7.11.597618469518
  70. 70. Gluckman, P. D., Hanson M. A. The fetal matrix: Evolution, development, and disease. Cambridge University Press: New York, 2005.
  71. 71. Gräff, J., Mansuy, I. M. Epigenetic codes in cognition and behavior. Behavioural Brain Research 192(1), 2008, pp. 70-87.10.1016/j.bbr.2008.01.02118353453
  72. 72. Gravlee, C. C. How race becomes biology: Embodiment of social inequality. American Journal of Physical Anthropology 139, 2009, pp. 47-57.10.1002/ajpa.2098319226645
  73. 73. Greiffenstein, M. F. Secular IQ increases by epigenesis? The hypothesis of cognitive genotype optimization. Psychological Reports 109(2), 2011, pp. 353-366.10.2466/03.04.10.19.PR0.109.5.353-36622238843
  74. 74. Griffiths, B. B., Hunter, R. G. Neuroepigenetics of stress. Neuroscience 275, 2014, pp. 420-435.10.1016/j.neuroscience.2014.06.04124976514
  75. 75. Grossniklaus, U., Kelly, W. G., Ferguson-Smith, A. C., Pembrey, M., Lindquist, S. Transgenerational epigenetic inheritance: How important is it? Nature Reviews Genetics 14(11), 2013, pp. 228-235.10.1038/nrg3435406684723416892
  76. 76. Gudbjartsson, D. F., Walters, G. B., Thorleifsson, G., Stefansson, H., Halldorsson, B. V., Zusmanovich, P., Sulem, P., Thorlacius, S., Gylfason, A., Steinberg, S., Helgadottir, A., Ingason, A., Steinthorsdottir, V., Olafsdottir, E. J., Olafsdottir, G. H., Jonsson, T., Borch-Johnsen, K., Hansen, T., Andersen, G., Jorgensen, T., Pedersen, O., Aben, K. K., Witjes, J. A., Swinkels, D. W., den Heijer, M., Franke, B., Verbeek, A. L., Becker, D. M., Yanek, L. R., Becker, L. C., Tryggvadottir, L., Rafnar, T., Gulcher, J., Kiemeney, L. A., Kong, A., Thorsteinsdottir, U., Stefansson, K. Many sequence variants affecting diversity of adult human height. Nature Genetics 40, 2008, pp. 609-615.10.1038/ng.12218391951
  77. 77. Gupta-Agarwal, S., Jarome, T. J., Fernandez, J., Lubin, F. D. NMDA receptor- and ERKdependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation. Learning & Memory 21(7), 2014, pp. 351-362.10.1101/lm.035105.114406142624939839
  78. 78. Hamatani, T. Human spermatozoal RNAs. Fertility and Sterility 97, 2012, pp. 275-281.10.1016/j.fertnstert.2011.12.03522289287
  79. 79. Haraksingh, R. R., Snyder, M. P. Impacts of variation in the human genome on gene regulation. Journal of Molecular Biology 425(21), 2013, pp. 3970-3977.10.1016/j.jmb.2013.07.01523871684
  80. 80. Harden, K. P., Hill, J. E., Turkheimer, E., Emery, R. E. Gene-environment correlation and interaction in peer effects on adolescent alcohol and tobacco use. Behavior Genetics 38, 2008, pp. 339-347.10.1007/s10519-008-9202-7289855818368474
  81. 81. Heard, E., Martienssen, R. A. Transgenerational Epigenetic Inheritance: Myths and Mechanisms. Cell 157, 2014, pp. 95-109.10.1016/j.cell.2014.02.045402000424679529
  82. 82. Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., Lumey, L. H. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proceedings of the National Academy of Sciences USA 105, 2008, pp. 17046-17049.10.1073/pnas.0806560105257937518955703
  83. 83. Heinzelmann, M., Gill, J. Epigenetic mechanisms shape the biological response to trauma and risk for PTSD: A critical review. Nursing Research and Practice 2013, 2013, p. 417010. 10.1155/2013/417010365433223710355
  84. 84. Hiemstra, M., Kleinjan, M., van Schayck, O. C., Engels, R. C., Otten, R. Environmental smoking and smoking onset in adolescence: the role of dopamine-related genes. Findings from two longitudinal studies. PLoS One 9(1), 2014, p. e86497.10.1371/journal.pone.0086497389772924466121
  85. 85. Hindorff, L. A, Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., Manolio, T. A. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proceedings of the National Academy of Sciences of the United States of America 106(23), 2009, pp. 9362-9367.10.1073/pnas.0903103106268714719474294
  86. 86. Imamura, T., Uesaka, M., Nakashima, K. Epigenetic setting and reprogramming for neural cell fate determination and differentiation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0511414203225135972
  87. 87. Jablonka, E. Epigenetic variations in heredity and evolution. Clinical Pharmacology and Therapeutics 92(6), 2012, pp. 683-688.10.1038/clpt.2012.15823073209
  88. 88. Jablonka, J., Raz, G. Transgenerational epigenetic inheritance: Prevalence, mechanisms, and implications for the study of heredity and evolution. Quarterly Review of Biology 84, 2009, pp. 131-176.10.1086/59882219606595
  89. 89. Jarome, T. J., Butler, A. A., Nichols, J. N., Pacheco, N. L., Lubin, F. D. NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation. Frontiers in Molecular Neuroscience 8, 2015, pp. 54.10.3389/fnmol.2015.00054458495626441517
  90. 90. Jarome, T. J., Thomas, J. S., Lubin, F. D. The epigenetic basis of memory formation and storage. Progress in Molecular Biology and Translational Science 28, 2014, pp. 1-27.10.1016/B978-0-12-800977-2.00001-225410539
  91. 91. Jia, Y., Chen, L., Ma, Y., Zhang, J., Xu, N., Liao, D.J. To know how a gene works, we need to redefine it first but then, more importantly, to let the cell itself decide how to transcribe and process its RNAs. International Journal of Biological Sciences 11(12), 2015, pp. 1413-1423.10.7150/ijbs.13436467199926681921
  92. 92. Jirtle, R. L., Skinner, M. K. Environmental epigenomics and disease susceptibility. Nature Reviews Genetics 8, pp. 253-262.10.1038/nrg2045594001017363974
  93. 93. Johnson, G. D., Lalancette, C., Linnemann, A. K., Leduc, F., Boissonneault, G., Krawetz, S. A. The sperm nucleus: Chromatin, RNA, and the nuclear matrix. Reproduction 141, 2011, pp. 21-36.10.1530/REP-10-0322535866920876223
  94. 94. Kaati, G., Bygren, L. O., Pembrey, M., Sjostrom, M. Transgenerational response to nutrition, early life circumstances and longevity. European Journal of Human Genetics 15(7), pp. 784-790.10.1038/sj.ejhg.520183217457370
  95. 95. Kahrer-Sawatzki, H. What a difference copy number variation makes. Bioessays 29(4), 2007, pp. 311-313.10.1002/bies.2055417373652
  96. 96. Kellermann, N. P. Epigenetic transmission of holocaust trauma: can nightmares be inherited? The Israel Journal of Psychiatry and Related Sciences 50(1), 2013, pp. 33-39.
  97. 97. Keverne, E. B., Curley, J. P. Epigenetics, brain evolution and behavior. Frontiers in Neuroendocrinology 29(3), 2008, pp. 398-412.10.1016/j.yfrne.2008.03.00118439660
  98. 98. Kevles, D. J. In the name of eugenics: Genetics and the uses of human heredity. Harvard University Press: Cambridge, MA, 1985.
  99. 99. Kim, D. H., Saetrom, P., Snove, O., Jr., Rossi, J. J. MicroRNA-directed transcriptional gene silencing in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 105, 2-8, pp. 16230-16235.10.1073/pnas.0808830105257102018852463
  100. 100. Kingsley, D. M. From atoms to traits. Scientific American 300(1), 2009, pp. 52-59.10.1038/scientificamerican0109-5219186749
  101. 101. Krawetz, S. A. Paternal contribution: New insights and future challenges. Nature Reviews Genetics 6, 2005, pp. 633-642.10.1038/nrg165416136654
  102. 102. Krawetz, S. A., Kruger, A., Lalancette, C., Tagett, R., Anton, E., Draghici, S., et al. A survey of small RNAs in human sperm. Human Reproduction 26, 2011, pp. 3401-3412.10.1093/humrep/der329321287921989093
  103. 103. Kubota ,T., Mochizuki, K. Epigenetic effect of environmental factors on autism spectrum disorders. International Journal of Environmental Research and Public Health 13(5), 2016, p. E504.10.3390/ijerph13050504488112927187441
  104. 104. Kuokkanen, M., Kokkonen, J., Enattah, N. S., Ylisaukko-oja, T., Komu, H., Varilo, T., Peltonen, L., Savilahti, E., Jarvela, I. Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency. American Journal of Human Genetics 78(2), 2006, pp. 339-344.10.1086/500053138024016400612
  105. 105. Kuzawa, C., Sweet, E. Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health. American Journal of Human Biology 21, 2009, pp. 2-15.10.1002/ajhb.2082218925573
  106. 106. Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M. J., Turecki, G. Genome-wide epigenetic regulation by earlylife trauma. Archives of General Psychiatry 69(7), 2012, pp. 722-731.10.1001/archgenpsychiatry.2011.2287499194422752237
  107. 107. Lander, E. S. Initial impact of the sequencing of the human genome. Nature 470(7333), 2011, pp. 187-197.
  108. 108. Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., McEwan, P., McKernan, K., Meldrim, J., Mesirov, J. P., Miranda, C., Morris, W., Naylor, J., Raymond, C., Rosetti, M., Santos, R., Sheridan, A., Sougnez, C., Stange-Thomann, Y., Stojanovic, N., Subramanian, A., Wyman, D., Rogers, J., Sulston, J., Ainscough, R., Beck, S., Bentley, D., Burton, J., Clee, C., Carter, N., Szustakowki, J., et al., International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409(6822), 2001, pp. 860-921. Erratum in: Nature 411(6838), 2001, pp. 720. Szustakowki, J. [corrected to Szustakowski, J]. Nature 412(6846), 2001, p. 565.
  109. 109. Leen-Feldner, E. W., Feldner, M. T., Knapp, A,, Bunaciu, L., Blumenthal, H., Amstadter, A.B. Offspring psychological and biological correlates of parental posttraumatic stress: review of the literature and research agenda. Clinical Psychology Review 33(8), 2013, pp. 1106-1133.10.1016/j.cpr.2013.09.00124100080
  110. 110. Lettre, G., Jackson, A. U., Gieger, C., Schumacher, F. R., Berndt, S. I., Sanna, S., Eyheramendy, S., Voight, B. F., Butler, J. L., Guiducci, C., Illig, T., Hackett, R., Heid, I. M., Jacobs, K. B., Lyssenko, V., Uda, M., et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nature Genetics 40, 2008, pp. 584-591.10.1038/ng.125268707618391950
  111. 111. Levy, Y., Ebstein, R. P. Research review: crossing syndrome boundaries in the search for brain endophenotypes. Journal of Child Psychology and Psychiatry, and Allied Disciplines 50(6), 2009, pp. 657-668.10.1111/j.1469-7610.2008.01986.x19175806
  112. 112. Liebers, R., Rassoulzadegan, M., Lyko, F. Epigenetic regulation by heritable RNA. PLoS Genetics 10(4), 2014, p. e1004296.10.1371/journal.pgen.1004296399047724743450
  113. 113. Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D. G., Mishkin, M., Vargha-Khadem, F. Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience 6(11), 2003, pp. 1230-1237.10.1038/nn1138
  114. 114. Lim, J. P., Brunet, A. Bridging the transgenerational gap with epigenetic memory. Trends in Genetics 29(3), 2013, pp. 176-186.10.1016/j.tig.2012.12.008
  115. 115. Liu, N., Pan, T. RNA epigenetics. Translational Research: The Journal of Laboratory and Clinical Medicine 165(1), 2015, pp. 28-35.10.1016/j.trsl.2014.04.003
  116. 116. Lock, M. The epigenome and nature/nurture reunification: a challenge for anthropology. Medical Anthropology 32(4), 2013, pp. 291-308.10.1080/01459740.2012.746973
  117. 117. Locke, J. Some Thoughts Concerning Education: Full and Fine 1693 Edition (Illustrated) Kindle Edition. www.WealthOfNation.com, 2014.10.1093/oseo/instance.00016977
  118. 118. Maccari, S., Krugers, H. J., Morley-Fletcher, S., Szyf, M., Brunton, P. J. The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. Journal of Neuroendocrinology 26(10), 2014, pp. 707-723.10.1111/jne.12175
  119. 119. Maher, B. Personal genomes: The case of the missing heritability. Nature 456(7218), 2008, pp. 18-21.
  120. 120. Makowsky, R., Pajewski, N. M., Klimentidis, Y. C., Vazquez, A. I., Duarte, C. W., Allison, D. B., de los Campos, G. Beyond Missing Heritability: Prediction of Complex Traits. PLoS Genetics 7, 2011, p. e1002051. 10.1371/journal.pgen.1002051
  121. 121. Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., Cho, J. H., Guttmacher, A. E., Kong, A., Kruglyak, L., Mardis, E., Rotimi, C. N., Slatkin, M., Valle, D., Whittemore, A. S., Boehnke, M., Clark, A. G., Eichler, E. E., Gibson, G., Haines, J. L., Mackay, T.F., McCarroll, S. A., Visscher, P. M. Finding the missing heritability of complex diseases. Nature 461, 2009, pp. 747-753.10.1038/nature08494
  122. 122. Mansuy, I. M., Mohanna, S. Epigenetics and the human brain: where nurture meets nature. Cerebrum 2011 May, 2011, p. 8.
  123. 123. Marcus, G. F., Fisher, S. E. FOXP2 in focus: what can genes tell us about speech and language? Trends in Cognitive Science 7(6), 2003, pp. 257-262.10.1016/S1364-6613(03)00104-9
  124. 124. Marian, A. J. Molecular genetic studies of complex phenotypes. Translational Research: The Journal of Laboratory and Clinical Medicine 159(2), 2012, pp. 64-79.10.1016/j.trsl.2011.08.001325953022243791
  125. 125. Marino, C., Mascheretti, S., Riva, V., Cattaneo, F., Rigoletto, C., Rusconi, M., Gruen, J. R., Giorda, R., Lazazzera, C., Molteni, M. Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia. Behavior Genetics 41(1), 2011, pp. 67-76.10.1007/s10519-010-9412-7393967621046216
  126. 126. Mascheretti, S., Riva, V., Giorda, R., Beri, S., Lanzoni, L. F., Cellino, M. R., Marino, C. KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia. Journal of Human Genetics 59(4), 2014, pp. 189-197.10.1038/jhg.2013.14124430574
  127. 127. McGowan, P. O., Szyf, M. The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiology of Disease 39(1), 2010, pp. 66-72.10.1016/j.nbd.2009.12.02620053376
  128. 128. Meloni, M., Testa, G. Scrutinizing the epigenetics revolution. Biosocieties 9(4), 2014, pp. 431-456.10.1057/biosoc.2014.22425506625484911
  129. 129. Miller, G. The seductive allure of behavioral epigenetics. Science 329, 2010, pp. 24-27.10.1126/science.329.5987.2420595592
  130. 130. Mitchell, E., Klein, S. L., Argyropoulos, K. V., Sharma, A., Chan, R. B., Toth, J. G., Barboza, L., Bavley, C., Bortolozzi, A., Chen, Q., Liu, B., Ingenito, J., Mark, W., Dudakov, J., Gross, S., Di Paolo, G., Artigas, F., van den Brink, M., Toth, M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature Communications 7, 2016, p. 11492.10.1038/ncomms11492486917627173585
  131. 131. Monsey, M. S., Ota, K. T., Akingbade, I. F., Hong, E. S., Schafe, G. E. Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdale. PLoS One 6(5), 2011, p. e19958.10.1371/journal.pone.0019958309885621625500
  132. 132. Morris, K. V. Chan, S.W.-L., Jacobsen, S.E., Looney, D.J. Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305, 2004, pp. 1289-1292.10.1126/science.110137215297624
  133. 133. Mozzi, A., Forni, D., Clerici, M., Pozzoli, U., Mascheretti, S., Guerini, F. R., Riva, S., Bresolin, N., Cagliani, R., Sironi, M. The evolutionary history of genes involved in spoken and written language: beyond FOXP2. Scientific Reports 6, 2016, p. 22157.10.1038/srep22157476644326912479
  134. 134. Mukamel, Z., Konopka, G., Wexler, E., Osborn, G. E., Dong, H., Bergman, M. Y., Levitt, P., Geschwind, D. H. Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. Journal of Neuroscience 31(32), 2011, pp. 11437-11442.10.1523/JNEUROSCI.0181-11.2011366761021832174
  135. 135. Nagy, C., Turecki, G. Transgenerational epigenetic inheritance: an open discussion. Epigenomics 7(5), 2015, pp. 781-790.10.2217/epi.15.4626344807
  136. 136. Naumova, O. Y., Lee, M., Koposov, R., Szyf, M., Dozier, M., Grigorenko, E. L. Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents”, Development and Psychopathology 24(1), 2012, 143-155.10.1017/S0954579411000605347085322123582
  137. 137. Nestler, E. J. Transgenerational epigenetic contributions to stress responses: fact or fiction? PLoS Biology 14(3), 2016, p. e1002426 (Correction: PLoS Biology 14(6), 2016, p. e1002486).
  138. 138. Newbury, D. F., Winchester, L., Addis, L., Paracchini, S., Buckingham, L. L., Clark, A., Cohen, W., Cowie, H., Dworzynski, K., Everitt, A., Goodyer, I. M., Hennessy, E., Kindley, A. D., Miller, L. L., Nasir, J., O'Hare, A., Shaw, D., Simkin, Z., Simonoff, E., Slonims, V., Watson, J., Ragoussis, J., Fisher, S. E., Seckl, J. R., Helms, P. J., Bolton, P. F., Pickles, A., Conti-Ramsden, G., Baird, G., Bishop, D. V., Monaco, A. P. CMIP and ATP2C2 modulate phonological short-term memory in language impairment. American Journal of Human Genetics 85(2), 2009, pp. 264-272.10.1016/j.ajhg.2009.07.004272523619646677
  139. 139. Nilsson, E. E., Skinner, M. K. Environmentally induced epigenetic transgenerational inheritance of disease susceptibility. Translational Research: The Journal of Laboratory and Clinical Medicine 165(1), 2015, pp. 12-17.10.1016/j.trsl.2014.02.003414847124657180
  140. 140. Olfson, E., Edenberg, H. J., Nurnberger, J., Jr., Agrawal, A., Bucholz, K. K., Almasy, L. A., Chorlian, D., Dick, D. M., Hesselbrock, V. M., Kramer, J. R., Kuperman, S., Porjesz, B., Schuckit, M. A., Tischfield, J. A., Wang, J. C., Wetherill, L., Foroud, T. M., Rice, J., Goate, A., Bierut, L. J. An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction. Alcoholism: Clinical and Experimental Research 38(10), 2014, pp. 2541-2549.
  141. 141. Painter, R., Osmond, C., Gluckman, P., Hanson, M., Phillips, D., Roseboom, T. J. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG: An International Journal of Obstetrics and Gynaecology 115, 2008, pp. 1243-1249.10.1111/j.1471-0528.2008.01822.x18715409
  142. 142. Paracchini, S. Dissection of genetic associations with language-related traits in populationbased cohorts. Journal of Neurodevelopmental Disorders 3, 2011, pp. 365-373.10.1007/s11689-011-9091-6323076321894572
  143. 143. Pearson, H. Genetics: what is a gene? Nature 441(7092), 2006, pp. 398-401.
  144. 144. Peixoto, L., Abel, T. The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology 38(1), 2013, pp. 62-76.10.1038/npp.2012.86352199422669172
  145. 145. Pennisi, E. Genomics. ENCODE project writes eulogy for junk DNA. Science 337(6099), pp. 1159-1161.
  146. 146. Perera, F., Herbstman, J. Prenatal environmental exposures, epigenetics, and disease. Reproductive Toxicology 31(3), 2011, pp. 363-373.10.1016/j.reprotox.2010.12.055317116921256208
  147. 147. Perroud, N., Rutembesa, E., Paoloni-Giacobino, A., Mutabaruka, J., Mutesa, L., Stenz, L., et al. The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis. The World Journal of Biological Psychiatry: the Official Journal of the World Federation of Societies of Biological Psychiatry 15(4), 2014, pp. 334-345.
  148. 148. Perry, G. H., Dominy, N. J., Claw, K. G., Lee, A. S., Fiegler, H., Redon, R., Werner, J., Villanea, F. A., Mountain, J. L., Misra, R., Carter, N. P., Lee, C., Stone, A. C. Diet and the evolution of human amylase gene copy number variation. Nature Genetics 39(10), 2007, pp. 1256-1260.10.1038/ng2123237701517828263
  149. 149. Pietschnig, .J, Voracek, M., Formann, A. K. Pervasiveness of the IQ rise: a cross-temporal meta-analysis. PLoS One 5(12), 2010, p. e14406.10.1371/journal.pone.0014406300867321203545
  150. 150. Plomin, R., DeFries, J. C., Knopik, V. S., Neiderhiser, J. M. Top 10 replicated findings from behavioral genetics. Perspectives on Psychological Science 11, 2016, pp. 3-23.10.1177/1745691615617439
  151. 151. Plomin, R., DeFries, J. C., McClearn, G. E., McGuffin, P. Behavioral genetics. Worth Publishers: New York, 2001.
  152. 152. Plomin, R., Kovas, Y. Generalist genes and learning disabilities. Psychological Bulletin 131, 2005, pp. 592-617.10.1037/0033-2909.131.4.592
  153. 153. Przeworski, M., Hudson, R. R., Di Rienzo, A. Adjusting the focus on human variation. Trends in Genetics 16(7), 2000, pp. 296-302.10.1016/S0168-9525(00)02030-8
  154. 154. Qureshi, I. A., Mehler, M. F. An evolving view of epigenetic complexity in the brain. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0506414202725135967
  155. 155. Radtke, K. M., Ruf, M., Gunter, H. M., Dohrmann, K., Schauer, M., Meyer, A., Elbert, T. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Translational Psychiatry 1, 2011, p. e21. 10.1038/tp.2011.21330951622832523
  156. 156. Radtke, K. M., Schauer, M., Gunter, H. M., Ruf-Leuschner, M., Sill, J., Meyer, A., Elbert, T. Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment. Translational Psychiatry 5, 2015, p. e571.10.1038/tp.2015.63447129426080088
  157. 157. Reich, D. E., Schaffner, S. F., Daly, M. J., McVean, G., Mullikin, J. C., Higgins, J. M., Richter, D. J., Lander, E. S., Altshuler, D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nature Genetics 32(1), 2002, pp. 135-142.10.1038/ng94712161752
  158. 158. Richards, E. J. Inherited epigenetic variation - revisiting soft inheritance. Nature Reviews Genetics 7, 2006, pp. 395-401.10.1038/nrg183416534512
  159. 159. Richardson, Sarah S. Maternal bodies in the postgenomic order: Gender and the explanatory landscape of epigenetics. In. Richardson S. S., Stevens H. (eds.). Postgenomics: Perspectives on biology after the genome. Duke University Press, 2015
  160. 160. Richardson, Sarah S., Daniels, C. R., Gillman, M. W., Golden, J., Kukla, R., Kuzawa, Ch., Rich-Edwards, J. Don’t blame the mothers. Nature 512, 2014, pp. 131-132.10.1038/512131a25119222
  161. 161. Rietveld, C. A., Esko, T., Davies, G., Pers, T. H., Turley, P., Benyamin, B., Chabris, C. F., Emilsson, V., Johnson, A. D., Lee, J. J., de Leeuw, C., Marioni, R. E., Medland, S. E., Miller, M. B., Rostapshova, O., van der Lee, S. J., Vinkhuyzen, A. A., Amin, N., Conley, D., Derringer, J., van Duijn, C. M., Fehrmann, R., Franke, L., Glaeser, E. L., et al. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proceedings of the National Academy of Sciences of the United States of America 111(38), 2014, pp. 13790-13794.10.1073/pnas.1404623111418331325201988
  162. 162. Rivera, C. M., Ren, B. Mapping human epigenomes. Cell 155, 2013, pp. 39-55.10.1016/j.cell.2013.09.011383889824074860
  163. 163. Roberts, T. C., Morris, K. V., Wood, M. J. The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1652), 2014.10.1098/rstb.2013.0507414202825135968
  164. 164. Rodgers, A. B, Bale, T. L. Germ cell origins of posttraumatic stress disorder risk: the transgenerational impact of parental stress experience. Biological Psychiatry 78(5), 2015, pp. 307-314.10.1016/j.biopsych.2015.03.018452633425895429
  165. 165. Rodgers, A. B, Morgan, C. P., Leu, N. A., Bale, T. L. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proceedings of the National Academy of Sciences of the United States of America 112(44), 2015, pp. 13699-13704.10.1073/pnas.1508347112464073326483456
  166. 166. Rose, N. R., Klose, R. J. Understanding the relationship between DNA methylation and histone lysine methylation. Biochimica et Biophysica Acta 1839(12), 2014, pp. 1362-72.10.1016/j.bbagrm.2014.02.007431617424560929
  167. 167. Roseboom, T., de Rooij, S. Painter, R. The Dutch famine and its long-term consequences for adult health. Early Human Development 82(8), 2006, pp. 485-491.10.1016/j.earlhumdev.2006.07.00116876341
  168. 168. Rutter, M., Moffitt, T. E., Caspi, A. Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry, and Allied Disciplines 47(3-4), 2006, pp. 226-61.10.1111/j.1469-7610.2005.01557.x16492258
  169. 169. Ruzicka, W. B. Epigenetic mechanisms in the pathophysiology of psychotic disorders. Harvard Review of Psychiatry 23(3), 2015, pp. 212-222.10.1097/HRP.0000000000000048554757525943315
  170. 170. Sapolsky, R. M. Mothering style and methylation. Nature Neuroscience 7(8), 2004, pp. 791-792.10.1038/nn0804-79115280887
  171. 171. Scerri, T. S., Morris, A. P., Buckingham, L. L., Newbury, D. F., Miller, L. L., Monaco, A. P., Bishop, D.V ., Paracchini, S. DCDC2, KIAA0319 and CMIP are associated with reading-related traits. Biological Psychiatry 70(3), 2011, pp. 237-245.10.1016/j.biopsych.2011.02.005313983621457949
  172. 172. Schubert, C. The genomic basis of the Williams-Beuren syndrome. Cellular and Molecular Life Sciences 66(7), 2009, pp. 1178-1197.10.1007/s00018-008-8401-y19039520
  173. 173. Shen, E., Shulha, H., Weng, Z., Akbarian, S. Regulation of histone H3K4 methylation in brain development and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369 (1652), 2014.10.1098/rstb.2013.0514414203525135975
  174. 174. Sherry, S. T., Ward, M. H., Kholodov, M., Baker, J., Phan, L., Smigielski, E. M., Sirotkin, K. dbSNP: the NCBI database of genetic variation. Nucleic Acid Research 29, 2001, pp. 308-311. 10.1093/nar/29.1.3082978311125122
  175. 175. Simmons, J. P., Nelson, L. D., Simonsohn, U. False-positive psychology: undisclosed flexibility in data collection and analysis allows presenting anything as significant. Psychological Science 22(11), 2011, pp.1359-1366.10.1177/095679761141763222006061
  176. 176. Simpson, J., Kelly, J. P. The impact of environmental enrichment in laboratory rats: Behavioural and neurochemical aspects. Behavioural Brain Research 222, 2011, pp. 246-264.10.1016/j.bbr.2011.04.00221504762
  177. 177. Skinner, M. K. Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Molecular and Cellular Endocrinology 398(1-2), 2014, pp. 4-12.10.1016/j.mce.2014.07.019426258525088466
  178. 178. Skinner, M. K. Environmental Epigenetics and a Unified Theory of the Molecular Aspects of Evolution: A Neo-Lamarckian concept that facilitates neo-Darwinian evolution. Genome Biology and Evolution 7(5), 2015, pp. 1296-302.10.1093/gbe/evv073445306825917417
  179. 179. Skinner, M. K. Environmental stress and epigenetic transgenerational inheritance. BMC Medicine 12, 2014, p. 153.10.1186/s12916-014-0153-y424405925259699
  180. 180. Skinner, M. K., Anway, M. D., Savenkova, M. I., Gore, A. C., Crews, D. Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS One 3, 2008, p. e3745.10.1371/journal.pone.0003745258144019015723
  181. 181. South, S. C., Krueger, R. F., Johnson, W., Iacono, W. G. Adolescent personality moderates genetic and environmental influences on relationships with parents. Journal of Personality and Social Psychology 94(5), 2008, pp. 899-912.10.1037/0022-3514.94.5.899260302718444746
  182. 182. Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., Geschwind, D. H. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. American Journal of Human Genetics 81(6), 2007, pp. 1144-1157.10.1086/522237227635017999357
  183. 183. Suderman, M., Borghol, N., Pappas, J. J., Pinto Pereira, S. M., Pembrey, M., Hertzman, C., Power, C., Szyf, M. Childhood abuse is associated with methylation of multiple loci in adult DNA. BMC Medical Genomics 7, 2014, p. 13.10.1186/1755-8794-7-13400763124618023
  184. 184. Szyf, M. DNA methylation, behavior and early life adversity. Journal of Genetics and Genomics 40(7), 2013, pp. 331-338.10.1016/j.jgg.2013.06.00423876773
  185. 185. Szyf, M. Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nature Neuroscience 17(1), 2014, pp. 2-4.10.1038/nn.360324369368
  186. 186. Szyf, M. The early-life social environment and DNA methylation. Clinical Genetics 81(4), 2012, pp. 341-349.10.1111/j.1399-0004.2012.01843.x22236068
  187. 187. Szyf, M., Bick, J. DNA methylation: a mechanism for embedding early life experiences in the genome. Child Development 84(1), 2013, pp. 49-57.10.1111/j.1467-8624.2012.01793.x403919922880724
  188. 188. Szyf, M., Weaver, I., Meaney, M. Maternal care, the epigenome and phenotypic differences in behavior. Reproductive Toxicology 24(1), 2007, pp. 9-19.10.1016/j.reprotox.2007.05.00117561370
  189. 189. Toth, M. Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology 40(1), 2015, pp. 129-140.10.1038/npp.2014.127426289024889369
  190. 190. Trahan, L. H., Stuebing, K. K., Fletcher, J. M., Hiscock, M. The Flynn effect: a meta-analysis. Psychological Bulletin 140(5), 2014, pp. 1332-1360.10.1037/a0037173415242324979188
  191. 191. Trerotola, M., Relli, V., Simeone, P., Alberti, S. Epigenetic inheritance and the missing heritability. Human Genomics 9, 2015, p. 17.10.1186/s40246-015-0041-3451741426216216
  192. 192. Trzaskowski, M., Dale, P. S., Plomin, R. No genetic influence for childhood behavior problems from DNA analysis. Journal of the American Academy of Child and Adolescent Psychiatry 52, 2013, pp.1048-1056.10.1016/j.jaac.2013.07.016391476024074471
  193. 193. Trzaskowski, M., Davis, O. S., DeFries, J. C., Yang, J., Visscher, P. M., Plomin, R. DNA evidence for strong genome-wide pleiotropy of cognitive and learning abilities. Behavior Genetics 43(4), 2013, pp. 267-73.10.1007/s10519-013-9594-x369018323609157
  194. 194. Tuddenham, R. D. Soldier intelligence in world wars I and II. American Psychologist 3, 1948, pp. 54-56. 10.1037/h005496218911933
  195. 195. Turkheimer, E. Spinach and ice cream: Why social science is so difficult. In. DiLalla, L. (ed.). Behavior genetics principles: Perspectives in development, personality, and psychopathology.
  196. American Psychological Association: Washington DC, 2004.
  197. 196. Usher, C. L., McCarroll, S. A. Complex and multi-allelic copy number variation in human disease. Briefings in Functional Genomics 14(5), 2015, pp. 329-338.10.1093/bfgp/elv028457675726163405
  198. 197. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., Gocayne, J. D., Amanatides, P., Ballew, R. M., Huson, D. H., Wortman, J. R., Zhang, Q., Kodira, C. D., Zheng, X. H., Chen, L., Skupski, M., Subramanian, G., Thomas, P. D., Zhang, J., et al. The sequence of the human genome. Science 291(5507), 2001, pp. 1304-1351. Erratum in: Science 292(5523), 2001, p. 1838.
  199. 198. Vernes, S. C., Newbury, D. F., Abrahams, B. S., Winchester, L., Nicod, J., Groszer, M., Alarcon, M., Oliver, P. L., Davies, K. E., Geschwind, D. H., Monaco, A. P., Fisher, S. E. A functional genetic link between distinct developmental language disorders. The New England Journal of Medicine 359(22), 2008, pp. 2337-2345.10.1056/NEJMoa0802828275640918987363
  200. 199. Waggoner, M. R., Tobias, U. Epigenetic determinism in science and society. New Genetics and Society 34:2, 2015, pp. 177-195.10.1080/14636778.2015.1033052451335226217167
  201. 200. Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., Meaney, M. J. Epigenetic programming by maternal behavior. Nature Neuroscience 7(8), 2004, pp. 847-854.10.1038/nn127615220929
  202. 201. Weber-Stadlbauer, U., Richetto, J., Labouesse, M. A., Bohacek, J., Mansuy, I. M., Meyer, U. Transgenerational transmission and modification of pathological traits induced by prenatal immune activation. Molecular Psychiatry Mar 29, 2016.10.1038/mp.2016.4127021823
  203. 202. Weedon, M. N., Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., Perry, J. R., Stevens, S., Hall, A. S., Samani, N. J., Shields, B., Prokopenko, I., Farrall, M., Dominiczak, A., et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nature Genetics 40, 2008, pp. 575-583.10.1038/ng.121268122118391952
  204. 203. Wei, Y., Schatten, H., Sun, Q. Y. Environmental epigenetic inheritance through gametes and implications for human reproduction. Human Reproduction Update 21(2), 2015, pp. 194-208.10.1093/humupd/dmu06125416302
  205. 204. Weiss, I. C., Franklin, T. B., Vizi, S., Mansuy, I. M. Inheritable effect of unpredictable maternal separation on behavioral responses in mice. Frontiers in Behavioral Neuroscience 5, 2011, p. 3.10.3389/fnbeh.2011.00003303493721331159
  206. 205. Welter, D., MacArthur, J., Morales, J., Burdett, T., Hall, P., Junkins, H., Klemm, A., Flicek, P., Manolio, T., Hindorff, L., Parkinson, H. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Research 42 (Database issue), 2014, pp. D1001-D1006.10.1093/nar/gkt1229396511924316577
  207. 206. West-Eberhard, M. J. Are genes good markers of biological traits? In. Weinstein, M., Vaupel, J. W., Wachter, K. W. (eds.). Biosocial Surveys. The National Academies Press: Washington DC, 2008.
  208. 207. Wolstenholme, J. T., Edwards, M., Shetty, S. R. J., Gatewood, J. D., Taylor, J. A., Rissman, E. F., et al. Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology 153, 2012, pp. 3828-3838.10.1210/en.2012-1195340434522707478
  209. 208. Yahyavi, S. T., Zarghami, M., Marwah, U. A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability. Revista Brasileira de Psiquiatria: Orgão Oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina 36(1), 2014, pp. 89-94.10.1590/1516-4446-2012-099524402183
  210. 209. Yan, W. Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance. Molecular and Cellular Endocrinology 398(1-2), 2014, pp. 24-30.10.1016/j.mce.2014.09.008426268125224488
  211. 210. Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., Goddard, M. E., Visscher, P. M. Common SNPs explain a large proportion of the heritability for human height. Nature Genetics 42, 2010, pp. 565-569. 10.1038/ng.608323205220562875
  212. 211. Yehuda, R., Daskalakis, N. P., Lehrner, A., Desarnaud, F., Bader, H. N., Makotkine, I., Flory, J. D., Bierer, L. M., Meaney, M. J. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. The American Journal of Psychiatry 171(8), 2014, pp. 872-880.10.1176/appi.ajp.2014.13121571412739024832930
  213. 212. Zhang, F., Lupski, J. R. Non-coding genetic variants in human disease. Human Molecular Genetics 24 (R1), 2015, pp. R102-R110.10.1093/hmg/ddv259457200126152199
  214. 213. Zheng, G., Dahl, J. A., Niu, Y., Fu, Y., Klungland, A., Yang, Y. G., He, C. Sprouts of RNA epigenetics. RNA Biology 10(6), 2013, pp. 915-918.10.4161/rna.24711390458923619745
  215. 214. Zuk, O., Hechter, E., Sunyaev, S. R., Lander, E. S. The mystery of missing heritability: Genetic interactions create phantom heritability. Proceedings of the National Academy of Sciences of the United States of America 109, 2012, pp. 1193-1198. 10.1073/pnas.1119675109326827922223662
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