OXA-48-Carbapenemase-Producing Klebsiella pneumoniae infections - the first cases diagnosed in Romanian National Institute of Infectious Diseases

Cristina Popescu; Gabriel Adrian Popescu; Olga Dorobăț; Alexandru Rafilă; Diana Tănase; Claudia Mikula; Gudrun Weissensteiner; Steliana Huhulescu

doi:10.1515/rrlm-2017-0006

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OXA-48-Carbapenemase-Producing Klebsiella pneumoniae infections - the first cases diagnosed in Romanian National Institute of Infectious Diseases

Revista Romana de Medicina de Laborator

Volume 25 (2017): Issue 1 (January 2017)

By: Cristina Popescu, Gabriel Adrian Popescu, Olga Dorobăț, Alexandru Rafilă, Diana Tănase, Claudia Mikula, Gudrun Weissensteiner and Steliana Huhulescu

Open Access

|Feb 2017

Abstract

We report first description of clinical cases of OXA-48 carbapenemase-producing Klebsiella pneumoniae originating from patients hospitalized in the most important Infectious Diseases Hospital from Romania, between December 2012 and March 2013. All strains were isolated from patients who were previously admitted in surgical wards. None of the patients had been admitted in a hospital outside of Romania.

References

1. Poirel L, Pitout JD, Nordmann P. Carbapenemases: molecular diversity and clinical consequences. Future Microbiol. 2007 Oct;2(5): 501-12. DOI: 10.2217/17460913.2.5.50110.2217/17460913.2.5.50117927473
Search in Google Scholar Back to article
2. Poirel L, Héritier C, Tolün V, Nordmann P. Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004 Jan;48(1):15–22. DOI: 10.1128/AAC.48.1.15-22.200410.1128/AAC.48.1.15-22.200431016714693513
Search in Google Scholar Back to article
3. Carrër A, Poirel L, Yilmaz M, Akan OA, Feriha C, Cuzon G, et al. Spread of OXA-48–encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother. 2010 Mar;54(3):1369–73. DOI: 10.1128/AAC.01312-0910.1128/AAC.01312-09282596520086157
Search in Google Scholar Back to article
4. Benouda A, Touzani O, Khairallah MT, Araj GF, Matar GM. First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco. Ann Trop Med Parasitol. 2010 Jun;104(4):327–30. DOI: 10.1179/136485910X1274355476010810.1179/136485910X1274355476010820659393
Search in Google Scholar Back to article
5. Poirel L, Potron A, Nordmann P. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother. 2012 Jul;67(7):1597-606. DOI: 10.1093/jac/dks12110.1093/jac/dks12122499996
Search in Google Scholar Back to article
6. Lascols C, Peirano G, Hackel M Laupland KB, Pitout JD. Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America. Antimicrob Agents Chemother. 2013 Jan;57(1):130-6. DOI: 10.1128/AAC.01686-1210.1128/AAC.01686-12353597823070171
Search in Google Scholar Back to article
7. Lascols C, Hackel M, Marshal SH, Hujer AM, Bouchillon S, Badal R, et al. Increasing prevalence and dissemination of NDM-1 metallo-betalactamases in India: data from the SMART study. J Antimicrob Chemother. 2009 Sep;66(9):1992-7. DOI: 10.1093/jac/dkr24010.1093/jac/dkr240315350221676902
Search in Google Scholar Back to article
8. Vaux S, Carbonne A, Thiolet JM, Jarlier V, Coignard B. Emergence of carbapenemase-producing enterobacteriaceae in France, 2004 to 2011. Euro Surveill. 2011 Jun;16(22):pii=19880.10.2807/ese.16.22.19880-en21663708
Search in Google Scholar Back to article
9. Osterblad M, Kirveskari J, Hakanen AJ, Tissari P, Vaara M, Jalava J. Carbapenemase-producing Enterobacteriaceae in Finland: the first years (2008-11). J Antimicrob Chemother. 2012 Dec;67(12):2860-4. DOI: 10.1093/jac/dks29910.1093/jac/dks29922855858
Search in Google Scholar Back to article
10. O’Brien DJ, Wrenn C, Roche C Rose L, Fenelon C, Flynn A, et al. First isolation and outbreak of OXA-48-producing Klebsiella pneumoniae in an Irish hospital, March to June 2011. Euro Surveillance. 2011 Jul;16(29):pii=19921.10.2807/ese.16.29.19921-en
Search in Google Scholar Back to article
11. European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment. Transfer of Libyan patients to hospitals in the European Union. Stockholm: ECDC; 31 Oct 2011.
Search in Google Scholar Back to article
12. Pirš M, Andlovic A, Cerar T, Žohar-Čretnik T, Kobola L, Kolman J, et al. A case of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a patient transferred to Slovenia from Libya, November 2011. Euro Surveill. 2011 Dec;16(50):pii=20042.10.2807/ese.16.50.20042-en
Search in Google Scholar Back to article
13. Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010 Mar; 65(3):490-5. DOI: 10.1093/jac/dkp49810.1093/jac/dkp49820071363
Search in Google Scholar Back to article
14. Perez-Perez FJ, Hanson ND. Detection of plasmid-mediated AmpC β-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol. 2002 Jun;40(6):2153-62. DOI: 10.1128/JCM.40.6.2153-2162.200210.1128/JCM.40.6.2153-2162.200213080412037080
Search in Google Scholar Back to article
15. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase-producing enterobacteriaceae. Emerg Infect Dis. 2011 Oct;17(10):1791–8. DOI: 10.3201/eid1710.11065510.3201/eid1710.110655331068222000347
Search in Google Scholar Back to article
16. Szekely E, Damjanova I, Janvari L, Vas K.E, Molnar S, Bilca DV, et al. First description of blaNDM−1, blaOXA−48, blaOXA−181 producing Enterobacteriaceae strains in Romania. Int J Med Microbiol.2013 Dec; 303(8): 697-700. DOI: 10.1016/j.ijmm.2013.10.00110.1016/j.ijmm.2013.10.00124183483
Search in Google Scholar Back to article
17. Dortet L, Flonta M, Boudehen Y-M, Creton E, Bernabeu S, Vogel A, et al. Dissemination of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa in Romania. Antimicrob Agents Chemother. 2015 Nov; 59(11) 7100-3. DOI: 10.1128/AAC.01512-1510.1128/AAC.01512-15460439126303798
Search in Google Scholar Back to article
18. Gheorghe I, Czobor I, Chifiriuc MC, Borcan E, Ghita C, Banu O et al. Molecular screening of carbapenemase-producing Gram-negative strains in Romanian intensive care units during a one year survey. J Med Microbiol. 2014 Oct; 63 (Pt 10):1303-10. DOI: 10.1099/jmm.0.074039-010.1099/jmm.0.074039-025060972
Search in Google Scholar Back to article
19. Timofte D, Panzaru CV, Maciuca IE, Dan M, Mare AD, Man A, et al. Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015. Euro Surveill. 2016 Jun 23; 21(25): pii=30262. DOI: 10.2807/1560-7917.ES.2016.21.25.3026210.2807/1560-7917.ES.2016.21.25.3026227363583
Search in Google Scholar Back to article
20. Van der Bij AK, Pitout JD. The role of international travel in the worldwide spread of multiresistant Enterobacteriaceae. J Antimicrob Chemother. 2012 Sep;67(9):2090-100. DOI: 10.1093/jac/dks21410.1093/jac/dks21422678728
Search in Google Scholar Back to article

Articles in this issue

DOI: https://doi.org/10.1515/rrlm-2017-0006 | Journal eISSN: 2284-5623 | Journal ISSN: 1841-6624

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Language: English

Page range: 55 - 61

Submitted on: Oct 28, 2016

Accepted on: Jan 14, 2017

Published on: Feb 18, 2017

Published by: Romanian Association of Laboratory Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Klebsiella pneumoniae,

OXA-48 carbapenemase,

ESBL,

risk factors for resistance

Related subjects:

Microbiology and virology

© 2017 Cristina Popescu, Gabriel Adrian Popescu, Olga Dorobăț, Alexandru Rafilă, Diana Tănase, Claudia Mikula, Gudrun Weissensteiner, Steliana Huhulescu, published by Romanian Association of Laboratory Medicine
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 25 (2017): Issue 1 (January 2017)