References
- 1. Wang HE, Devereaux RS, Yealy DM, Safford MM, Howard G. National variation in United States sepsis mortality: a descriptive study. Int J Health Geogr. 2010 Feb 15;9:9. DOI: 10.1186/1476-072X-9-9
- 2. Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence. 2014 Jan 1;5(1):4–11. DOI: 10.4161/viru.27372
- 3. Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013 May;41(5):1167–74. DOI: 10.1097/CCM.0b013e31827c09f8
- 4. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007 May;35(5):1244–50. DOI: 10.1097/01.CCM.0000261890.41311.E9
- 5. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992 Jun;101(6):1644–55. DOI: 10.1378/chest.101.6.1644
- 6. Pietropaoli AP, Glance LG, Oakes D, Fisher SG. Gender differences in mortality in patients with severe sepsis or septic shock. Gend Med. 2010 Oct;7(5):422–37. DOI: 10.1016/j.genm.2010.09.005
- 7. Nasir N, Jamil B, Siddiqui S, Talat N, Khan FA, Hussain R. Mortality in Sepsis and its relationship with Gender. Pakistan J Med Sci. 2015 Sep-Oct;31(5):1201–6. DOI: 10.12669/pjms.315.6925
- 8. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. 2012 Jun;10(6):701–6. DOI: 10.1586/eri.12.50
- 9. Wiersinga WJ, Leopold SJ, Cranendonk DR, van der Poll T. Host innate immune responses to sepsis. Virulence. 2014 Jan 1;5(1):36–44. DOI: 10.4161/viru.25436
- 10. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010 Feb;36(2):222–31. DOI: 10.1007/s00134-009-1738-3
- 11. Kaukonen K-M, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis. N Engl J Med. 2015 Mar;372(17):1629-38. DOI: 10.1056/NEJMoa1415236
- 12. Cohen IL, Lambrinos J. Investigating the impact of age on outcome of mechanical ventilation using a population of 41,848 patients from a statewide database. Chest. 1995 Jun;107(6):1673–80. DOI: 10.1378/chest.107.6.1673
- 13. Bochicchio G V, Joshi M, Knorr KM, Scalea TM. Impact of nosocomial infections in trauma: does age make a difference? J Trauma. 2001 Apr;50(4):612–9. DOI: 10.1097/00005373-200104000-00004
- 14. Giamarellos-Bourboulis EJ, Mega A, Grecka P, Scarpa N, Koratzanis G, Thomopoulos G, et al. Procalcitonin: a marker to clearly differentiate systemic inflammatory response syndrome and sepsis in the critically ill patient? Intensive Care Med. 2002 Sep;28(9):1351–6. DOI: 10.1007/s00134-002-1398-z
- 15. Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother. 2011 Apr; 66 Suppl 2:ii33–40. DOI: 10.1093/jac/dkq523
- 16. Jensen JU, Heslet L, Jensen TH, Espersen K, Steffensen P, Tvede M. Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med. 2006 Oct; 34(10):2596–602. DOI: 10.1097/01.CCM.0000239116.01855.61
- 17. Pettilä V, Hynninen M, Takkunen O, Kuusela P, Valtonen M. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med. 2002 Sep; 28(9):1220–5. DOI: 10.1007/s00134-002-1416-1
- 18. Devran O, Karakurt Z, Adıgüzel N, Güngör G, Moçin OY, Balcı MK, et al. C-reactive protein as a predictor of mortality in patients affected with severe sepsis in intensive care unit. Multidiscip Respir Med. 2012 Jan; 7(1):47. DOI: 10.1186/2049-6958-7-47
- 19. Lobo SMA, Lobo FRM, Bota DP, Lopes-Ferreira F, Soliman HM, Mélot C, et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest. 2003 Jun; 123(6):2043–9. DOI: 10.1378/chest.123.6.2043
- 20. Hirasawa H, Oda S, Nakamura M. Blood glucose control in patients with severe sepsis and septic shock. World J Gastroenterol. 2009 Sep 7; 15(33):4132–6. DOI: 10.3748/wjg.15.4132
- 21. Ali NA, O’Brien JM, Dungan K, Phillips G, Marsh CB, Lemeshow S, et al. Glucose variability and mortality in patients with sepsis. Crit Care Med. 2008 Aug; 36(8):2316–21. DOI: 10.1097/CCM.0b013e3181810378
- 22. Waeschle RM, Moerer O, Hilgers R, Herrmann P, Neumann P, Quintel M. The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability. Crit Care. 2008 Jan;12(5):R129. DOI: 10.1186/cc7097
- 23. Treggiari MM, Karir V, Yanez ND, Weiss NS, Daniel S, Deem SA. Intensive insulin therapy and mortality in critically ill patients. Crit Care. 2008 Jan;12(1):R29. DOI: 10.1186/cc6807
- 24. Wiener RS, Wiener DC, Larson RJ. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA. 2008 Aug 27;300(8):933–44. DOI: 10.1001/jama.300.8.933
- 25. Merz TM, Finfer S. Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients? Crit Care. 2008 Jan;12(2):212. DOI: 10.1186/cc6837
- 26. Trimarchi H, Nozieres C, Cámpolo Girard V, Lombi F, Smith C, Young P, et al. Acute kidney injury in severe sepsis. Medicina (B Aires). 2009 Jan;69(3):321–6.
- 27. Oppert M, Engel C, Brunkhorst F-M, Bogatsch H, Reinhart K, Frei U, et al. Acute renal failure in patients with severe sepsis and septic shock--a significant independent risk factor for mortality: results from the German Prevalence Study. Nephrol Dial Transplant. 2008 Mar;23(3):904–9. DOI: 10.1093/ndt/gfm610
- 28. Metnitz GH, Fischer M, Bartens C, Steltzer H, Lang T, Druml W. Impact of acute renal failure on antioxidant status in multiple organ failure. Acta Anaesthesiol Scand. 2000 Mar;44(3):236–40. DOI: 10.1034/j.1399-6576.2000.440304.x
- 29. du Cheyron D, Parienti J-J, Fekih-Hassen M, Daubin C, Charbonneau P. Impact of anemia on outcome in critically ill patients with severe acute renal failure. Intensive Care Med. 2005 Nov;31(11):1529–36. DOI: 10.1007/s00134-005-2739-5
- 30. Arnold RC, Shapiro NI, Jones AE, Schorr C, Pope J, Casner E, et al. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009 Jul;32(1):35–9. DOI: 10.1097/SHK.0b013e3181971d47
- 31. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest. 1991 Apr;99(4):956–62. DOI: 10.1378/chest.99.4.956
- 32. Schollin-Borg, M; Nordin, P.; Zetterström, H.; Johansson J. Blood Lactate Is a Useful Indicator for the Medical Emergency Team. Crit Care Res Pract. 2016 Mar 3:1–7. DOI: 10.1155/2016/5765202
- 33. Londoño J, León AL, Rodríguez F, Barrera L, de la Rosa G, Dennis R, et al. Serum lactate in the emergency department as a prognostic factor in patients with sepsis without hypotension. Med clínica. 2013 Sep 21;141(6):246–51.
- 34. Jansen TC, van Bommel J, Schoonderbeek FJ, Sleeswijk Visser SJ, van der Klooster JM, Lima AP, et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med. 2010 Sep 15;182(6):752–61. DOI: 10.1164/rccm.200912-1918OC
- 35. Malmir J, Bolvardi E, Afzal Aghaee M. Serum lactate is a useful predictor of death in severe sepsis and septic shock. Rev Clin Med. 2014 Jun 1;1(3):97–104.
- 36. Claushuis TAM, van Vught LA, Scicluna BP, Wiewel MA, Klein Klouwenberg PMC, Hoogendijk AJ, et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood. 2016 Mar;127(24):3062-72. DOI: 10.1182/blood-2015-11-680744
- 37. de Stoppelaar SF, van ‚t Veer C, van der Poll T. The role of platelets in sepsis. Thromb Haemost. 2014 Jun 26;112(4):666–77. DOI: 10.1160/TH14-02-0126
- 38. De Oliveira Boechat T, Da Silveira MFBB, Faviere W, De MacEdo GL. Thrombocytopenia in sepsis: An important prognosis factor. Rev Bras Ter Intensiva. 2012 Mar;24(1):35–42.
- 39. Akca S, Haji-Michael P, de Mendonça A, Suter P, Levi M, Vincent JL. Time course of platelet counts in critically ill patients. Crit Care Med. 2002 Apr;30(4):753–6. DOI: 10.1097/00003246-200204000-00005