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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease Cover

Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease

Romanian Journal of Internal Medicine
Volume 53 (2015): Issue 1 (March 2015)
By: ,  ,  ,   and    
Open Access
|Oct 2015
References

References

  1. 1. CHEUNG O, KAPOOR A, PURI P, SISTRUN S, LUKETIC VA, SARGEANT CC, CONTOS MJ, SHIFFMAN ML, STRAVITZ RT, STERLING RK, SANYAL AJ. The impact of fat distribution on the severity of nonalcoholic fatty liver disease and metabolic syndrome. Hepatology 2007; 46(4): 1091-1100.
    Open DOISearch in Google Scholar
  2. 2. SANYAL AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology 2002; 123: 1705-1725.
    Open DOISearch in Google Scholar
  3. 3. MARCHESINI G, BUGIANESI E, FORLANI G, CERRELLI F, LENZI M, MANINI R, NATALE S, VANNI E, VILLANOVA N, MELCHIONDA N, RIZZETTO M. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003; 37: 917-923.
    Open DOISearch in Google Scholar
  4. 4. FORD ES, GILES WH, DIETZ WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359.
    Open DOISearch in Google Scholar
  5. 5. JAMES WP. OVERWEIGHT AND OBESITY. IN: EZZATI A, LOPEZ HD, ROGERS HR, MURRAY CJL, eds. WHO Comparative Quantification of Health Risks. Volume 1. Geneva, Switzerland: World Health Organization, 2003: 497-596.
    Search in Google Scholar
  6. 6. BJORNTORP P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14: 1132-1143.
    Open DOISearch in Google Scholar
  7. 7. GOODPASTER BH, KRISHNASWAMI S, HARRIS TB, KATSIARAS A, KRITCHEVSKY SB, SIMONSICK EM, NEVITT M, HOLVOET P, NEWMAN AB. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005; 165:777-783.
    Open DOISearch in Google Scholar
  8. 8. STANTON MC, CHEN SC, JACKSON JV, ROJAS-TRIANA A, KINSLEY D, CUI L, FINE JS, GREENFEDER S, BOBER LA, JENH CH. Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. J Inflamm (Lond). 2011; 8:8.
    Open DOISearch in Google Scholar
  9. 9. PARK SH, KIM BI, KIM SH, KIM HJ, PARK DI, CHO YK, SUNG IK, SOHN CI, KIM H, KEUM DK, KIM HD, PARK JH, KANG JH, JEON WK. Body fat distribution and insulin resistance: beyond obesity in nonalcoholic fatty liver disease among overweight men. J Am Coll Nutr 2007; 26:321-326.
    Open DOISearch in Google Scholar
  10. 10. PARK BJ, KIM YJ, KIM DH, KIM W, JUNG YJ, YOON JH, KIM CY, CHO YM, KIM SH, LEE KB, JANG JJ, LEE HS. Visceral adipose tissue area is an independent risk factor for hepatic steatosis. J Gastroenterol Hepatol 2008; 23:900-907.
    Open DOISearch in Google Scholar
  11. 11. VEGA GL, ADAMS-HUET B, PESHOCK R, WILLETT D, SHAH B, GRUNDY SM. Influence of body fat content and distribution on variation in metabolic risk. J Clin Endocrinol Metab 2006; 91: 4459-4466.
    Open DOISearch in Google Scholar
  12. 12. TARGHER G, MARRA F, MARCHESINI G. Increased risk of cardio-vascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 2008; 51: 1947-1953.
    Search in Google Scholar
  13. 13. MISRA VL, KHASHAB M, CHALASANI N. Nonalcoholic fatty liver disease and cardiovascular risk. Curr Gastroenterol Rep 2009; 11:50-55.
    Open DOISearch in Google Scholar
  14. 14. BIDDINGER SB, HERNANDEZ-ONO A, RASK-MADSEN C, HAAS JT, ALEMAN JO, SUZUKI R, SCAPA EF, AGARWAL C, CAREY MC, STEPHANOPOULOS G, COHEN DE, KING GL, GINSBERG HN, KAHN CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008; 7:125-134.
    Open DOISearch in Google Scholar
  15. 15. IRWIN ML, AINSWORTH BE, MAYER-DAVIS EJ, ADDY CL, PATE RR, DURSTINE JL. Physical activity and the metabolic syndrome in a tri-ethnic sample of women. Obes Res 2002; 10:1030.
    Open DOISearch in Google Scholar
  16. 16. KATZMARZYK PT, CHURCH TS, BLAIR SN. Cardiorespiratory fitness attenuates the effects of the metabolic syndrome on all-cause and cardiovascular disease mortality in men. Arch Intern Med 2004; 164:1092-1097.
    Open DOISearch in Google Scholar
  17. 17. CHURCH TS, KUK JL, ROSS R, PRIEST EL, BILTOFT E, BLAIR SN. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 2006; 130:2023-2030.
    Open DOISearch in Google Scholar
  18. 18. PERSEGHIN G, LATTUADA G, DE COBELLI F, RAGOGNA F, NTALI G, ESPOSITO A, BELLONI E, CANU T, TERRUZZI I, SCIFO P, DEL MASCHIO A, LUZI L. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 2007; 30:683-688.
    Open DOISearch in Google Scholar
  19. 19. JOHNSON NA, GEORGE J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 2010; 52(1):370-381.
    Open DOISearch in Google Scholar
  20. 20. KANTARTZIS K, THAMER C, PETER A, MACHANN J, SCHICK F, SCHRAML C, KÖNIGSRAINER A, KÖNIGSRAINER I, KRÖBER S, NIESS A, FRITSCHE A, HÄRING HU, STEFAN N. High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease. Gut 2009; 58:1281-1288.
    Open DOISearch in Google Scholar
  21. 21. NEUSCHWANDER-TETRI BA, CALDWELL SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37:1202-1219.
    Open DOISearch in Google Scholar
  22. 22. ZELBER-SAGI S, NITZAN-KALUSKI D, GOLDSMITH R, WEBB M, ZVIBEL I, GOLDINER I, BLENDIS L, HALPERN Z, OREN R. Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study. Hepatology 2008; 48(6): 1791-1798.
    Open DOISearch in Google Scholar
  23. 23. WILLIAMS MA, HASKELL WL, ADES PA, AMSTERDAM EA, BITTNER V, FRANKLIN BA, GULANICK M, LAING ST, STEWART KJ; American Heart Association Council on Clinical Cardiology; American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Resistance exercise in individuals with and without cardiovascular disease. 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2007; 116:572-584.
    Open DOISearch in Google Scholar
  24. 24. LAWLOR DA, SATTAR N, SMITH GD, EBRAHIM S. The associations of physical activity and adiposity with alanin aminotransferase and gamma glutamyltransferase. Am J Epidemiol 2005; 161:1081-1088.
    Open DOISearch in Google Scholar
  25. 25. KHAOSHBATEN M, GHOLAMI N, SOKHTEHZARI S, MONAZAMI AH, NEJAD MR. The effect of an aerobic exercise on serum level of liver enzymes and liver echogenicity in patients with non-alcoholic fatty liver disease. Gastroenterol Hepatol Bed Bench 2013; 6 (Suppl.1):S112-S116).
    Search in Google Scholar
  26. 26. KEATING SE, HACKETT DA, GEORGE J, JOHNSON NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2012; 57: 157-166.
    Open DOISearch in Google Scholar
  27. 27. RECTOR RS, THYFAULT JP, MORRIS RT, LAYE MJ, BORENGASSER SJ, BOOTH FW, IBDAH JA. Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats. Am J Physiol Gastrointest Liver Physiol 2008; 294: G619-G626.
    Open DOISearch in Google Scholar
  28. 28. ROCHA R, COTRIM HP, CARVALHO FM, SIQUEIRA AC, BRAGA H, FREITAS LA. Body mass index and waist circumference in nonalcoholic fatty liver disease. J Hum Nutr Diet 2005; 18: 365-370.
    Open DOISearch in Google Scholar
  29. 29. DESPRES JP, LEMIEUX I, BERGENON J, PIBAROT P, MATHIEU P, LAROSE E, RODÉS-CABAU J, BERTRAND OF, POIRIER P. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Tromb Vasc Biol 2008; 28: 1039-1049.
    Open DOISearch in Google Scholar
  30. 30. MATHURIN P, HOLLEBECQUE A, ARNALSTEEN L, BUOB D, LETEURTRE E, CAIAZZO R, PIGEYRE M, VERKINDT H, DHARANCY S, LOUVET A, ROMON M, PATTOU F. Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 2009; 137: 532-540.
    Open DOISearch in Google Scholar
  31. 31. SIRI-TARINO PW, SUN Q, HU FB, KRAUSS RM. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 2010; 12: 384-390.
    Open DOISearch in Google Scholar
  32. 32. DE LUIS DA, ALLER R, IZAOLA O, GONZALEZ SAGRADO M, CONDE R. Effect of two different hypocaloric diets in transaminases and insulin resistance in nonalcoholic fatty liver disease and obese patients. Nutr Hosp 2010; 25: 730-735.
    Search in Google Scholar
  33. 33. PROMRAT K, KLEINER DE, NIEMEIER HM, JACKVONY E, KEARNS M, WANDS JR, FAVA JL, WING RR. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010, 51 (1): 121-129.
    Open DOISearch in Google Scholar
  34. 34. CHEN SM, LIU CY, LI SR, HUANG HT, TSAI CY, JOU HJ. Effects of therapeutic lifestyle program on ultrasound-diagnosed nonalcoholic fatty liver disease. J Clin Med Assoc 2008; 71:551-558.
    Open DOISearch in Google Scholar
  35. 35. CHITTURI S, FARRELL G, FROST L, KRIKETOS A, LIN R, FUNG C, LIDDLE C, SAMARASINGHE D, GEORGE J. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 2002; 36: 403-409.
    Search in Google Scholar
  36. 36. BAJAJ M, SURAAMORNKUL S, HANDIES LJ, PRATIPANAWATR T, DEFRONZO RA. Plasma resistin concentration, hepatic fat content and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients. Int J Obes Relat Metab Disord 2004; 28: 783-789.
    Open DOISearch in Google Scholar
  37. 37. DYCK DJ. Leptin sensitivity in skeletal muscle is modulated by diet and exercise. Exerc Sport Sci Rev 2005; 33: 189-194.
    Open DOISearch in Google Scholar
  38. 38. GOMEZ-MERINO D, CHENNAOUI M, DROGOU C, BONNEAU D, GUEZENNEC CY. Decrease in serum leptin after prolonged physical activity in men. Med Sci Sports Exerc 2002; 34: 1594-1599.
    Open DOISearch in Google Scholar
  39. 39. FISHMAN S, MUZUMDAR RH, ATZMON G, MA X, YANG X, EINSTEIN FH, BARZILAI N. Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo. FASEB J 2007; 21: 53-60.
    Open DOISearch in Google Scholar
  40. 40. THONG FS, HUDSON R, ROSS R, JANSSEN I, GRAHAM TE. Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise. Am J Physiol Endocrinol Metab 2000; 279(2): E307-13.
    Open DOISearch in Google Scholar
  41. 41. CHATTERJEE S, GANINI D, TOKAR EJ, KUMAR A, DAS S, CORBETT J, KADIISKA MB, WAALKES MP, DIEHL AM, MASON RP. Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. J Hepatol 2013; 58:778-784.
    Open DOISearch in Google Scholar
  42. 42. KAMMOUN HL, CHABANON H, HAINAULT I, LUQUET S, MAGNAN C, KOIKE T, FERRÉ P, FOUFELLE F. GRP78 expression inhibits insulin and ER stress - induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 2009; 119: 1201-1215.
    Open DOISearch in Google Scholar
  43. 43. TARGHER G, BERTOLINI L, ZENARI L. Hypoadiponectinemia is closely associated with nonalcoholic hepatic steatosis in obese subjects. Diabetes Care 2004; 27: 2085-2086.
    Open DOISearch in Google Scholar
  44. 44. BRAY GA, JABLONSKI KA, FUJIMOTO WY, BARRETT-CONNOR E, HAFFNER S, HANSON RL, HILL JO, HUBBARD V, KRISKA A, STAMM E, PI-SUNYER FX. Diabetes Prevention Program Research Group. Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program. Am J Clin Nutr 2008; 87:1212-8.
    Open DOISearch in Google Scholar
  45. 45. LAZO M, SOLGA SF, HORSKA A, BONEKAMP S, DIEHL AM, BRANCATI FL, WAGENKNECHT LE, PI-SUNYER FX, KAHN SE, CLARK JM. Fatty Liver Subgroup of the Look AHEAD Research Group. Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care 2010; 33: 2156-2163.
    Open DOISearch in Google Scholar
  46. 46. HWANG JH, STEIN DT, BARZILAI N, CUI MH, TONELLI J, KISHORE P, HAWKINS M. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 2007; 293: E1663-E1669.
    Open DOISearch in Google Scholar
  47. 47. KORENBLAT KM, FABBRINI E, MOHAMMED BS, KLEIN S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008; 134: 1369-1375.
    Open DOISearch in Google Scholar
  48. 48. SHEN W, WANG Z, PUNYANITA M, LEI J, SINAV A, KRAL JG, IMIELINSKA C, ROSS R, HEYMSFIELD SB. Adipose tissue quantification by imaging methods: a proposed classification. Obes Res 2003; 11:5-16.
    Open DOISearch in Google Scholar
  49. 49. ST GEORGE A, BAUMAN A, JOHNSTON A, FARRELL G, CHEY T, GEORGE J. Independent effects of physical activity in patients with nonalcoholic fatty liver disease. Hepatology 2009; 50: 68-76.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.1515/rjim-2015-0008 | Journal eISSN: 2501-062X (formerly 1220-4749) | Journal ISSN: 1220-4749
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Language: English, Romanian
Page range: 56 - 64
Submitted on: Feb 15, 2015
Published on: Oct 7, 2015
Published by: N.G. Lupu Internal Medicine Foundation
In partnership with: Paradigm Publishing Services
Keywords:
non-alcoholic fatty liver disease,
weight reduction,
steatosis
Related subjects:
Medicine,
Clinical medicine,
Internal medicine,
Internal medicine, other,
Cardiology,
Gastroenterology,
Rheumatology

© 2015 Ionel Copaci, Ioana Lupescu, Elena Caceaune, Grethi Chiriac, G. Ismail, published by N.G. Lupu Internal Medicine Foundation
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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