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Prognostic significance of tumor regression in locally advanced rectal cancer after preoperative radiochemotherapy Cover

Prognostic significance of tumor regression in locally advanced rectal cancer after preoperative radiochemotherapy

By: Mirko Omejc and  Maja Potisek  
Open Access
|Dec 2017

Figures & Tables

Figure 1

Survival according to (A) postoperative T (ypT), (B) postoperative N (ypN) and (C) postoperative stage (yS).
Survival according to (A) postoperative T (ypT), (B) postoperative N (ypN) and (C) postoperative stage (yS).

Figure 2

Survival according to response to neoadjuvant therapy (0: no response,1: response): (A) group of patients with preoperative stage II, (B) group of patients with preoperative stage III.
Survival according to response to neoadjuvant therapy (0: no response,1: response): (A) group of patients with preoperative stage II, (B) group of patients with preoperative stage III.

Results of multivariate analysis

Hazard ratio95% confidence intervalp
ypT1.3070.847–2.0140.226
ypN1.5070.935–2.4280.092
Postoperative stage1.2680.793–2.0270.793
Downstaging (response to preoperative therapy)2.7251.4–5.30.003

Results of survival analysis

Median survival [years]95% confidence intervalp (log rank)
Pooperative stage 06.66.1–7.10.001
pooperative stage I6.45.8–6.9
Pooperative stage II5.54.9–6.1
Pooperative stage III4.94.3–5.6
Pooperative stage IV3.72.8–4.6
ypT06.66.1–6.70.011
ypT16.05.2–6.9
ypT26.15.5–6.7
ypT35.34.8–5.8
ypT43.92.0–5.8
ypN06.15.8–6.5< 0.001
ypN15.24.4–6.0
ypN23.73.0–4.4
Preoperative stage II5.85.0–6.60.389
Preoperative stage III5.65.1–6.0
DOI: https://doi.org/10.1515/raon-2017-0059 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 30 - 35
Submitted on: Sep 11, 2017
Accepted on: Oct 8, 2017
Published on: Dec 7, 2017
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2017 Mirko Omejc, Maja Potisek, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.