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PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung Cover

PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung

Open Access
|Sep 2017

Figures & Tables

Figure 1

PD-L1 expression in NSCLC. Positive membranous reaction in tumor cells in adenocarcinoma (A), and squamous-cell carcinoma (B), positive cytoplasmic reaction in immune cells (C), negative reaction in adenocarcinoma (D).
PD-L1 expression in NSCLC. Positive membranous reaction in tumor cells in adenocarcinoma (A), and squamous-cell carcinoma (B), positive cytoplasmic reaction in immune cells (C), negative reaction in adenocarcinoma (D).

Figure 2

Proportions of PD-L1 positive samples of adenocarcinoma and squamous-cell carcinoma in tumor cells (TC) and i mmune cells (IC) at pre-defined cut-off values (≥ 5% and ≥ 10%) with corresponding p values.
Proportions of PD-L1 positive samples of adenocarcinoma and squamous-cell carcinoma in tumor cells (TC) and i mmune cells (IC) at pre-defined cut-off values (≥ 5% and ≥ 10%) with corresponding p values.

Clinicopathological patient characteristics

TotalN = 54
Histology
     Squamous-cell carcinoma25 (46%)
     Adenocarcinoma29 (54%)
Sex
     Male34 (63%)
     Female20 (37%)
Age (years)
     Mean (SD)62.4 (8.6)
Smoking status
     Current smoker25 (46%)
     Former-smoker (>1 year)21 (39%)
     Non-smoker0 (0%)
     Unknown8 (15%)

PD-L1 positivity according to histology for cut-off value of 5% and higher and 10% and higher

Tumor specimens N

PD-L1 positivity (cut-off ≥ 5%)PD-L1 positivity (cut-off ≥ 10%)

TC or ICTCICp valueTC or ICTCICp value

N (%)N (%)N (%)TC vs. ICN (%)N (%)N (%)TC vs. IC
Total5443 (80)18 (33)40 (74) 31 (57)17 (31)28 (52)
Adenocarcinoma2921 (72)5 (17)21 (72)< 0.00112 (41)4 (14)12 (41)0.008
Squamous-cell carcinoma2522 (88)13 (52)19 (76)0.14619 (76)13 (52)16 (64)0.508
DOI: https://doi.org/10.1515/raon-2017-0037 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 357 - 362
Submitted on: Apr 27, 2017
Accepted on: Aug 9, 2017
Published on: Sep 14, 2017
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2017 Urska Janzic, Izidor Kern, Andrej Janzic, Luka Cavka, Tanja Cufer, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution 4.0 License.