Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Performance pooled analysis for MRI, diffusion weighted imaging (DWI), dynamic contrast enhanced MRI (DCE-MRI), PET/CT and multimodal imaging
| Performance | Sensitivity | Specificity | Positive | Negative | Accuracy |
|---|---|---|---|---|---|
| MRI | 75,84 | 78,21 | 74,34 | 79,55 | 77,13 |
| DCE-MRI | 87,18 | 84,15 | 82,42 | 88,51 | 85,55 |
| DWI | 75,95 | 79,25 | 84,51 | 68,85 | 77,27 |
| PET/CT | 80,25 | 83,08 | 79,27 | 83,92 | 81,82 |
| MULTIMODAL IMAGING | 85,00 | 96,08 | 89,47 | 94,23 | 92,96 |
Number of studies and participants for each diagnostic modality
| Diagnostic modality | Studies | Participants |
|---|---|---|
| MRI | 6 | 329 |
| DCE-MRI | 6 | 340 |
| DWI | 4 | 133 |
| PET/CT | 7 | 366 |
| MULTIMODAL IMAGING | 2 | 70 |
Main characteristics summary of included studies in the systematic review: for each study the table reports imaging modality used; number of patients examined; parameters examined
| Imaging modality | Authors | Approach | N. patients | Gold standard |
|---|---|---|---|---|
| Barbaro et al.69 | Score system | 53 | TNM | |
| Denecke et al.46 | Morphologic criteria | 23 | TNM | |
| MRI | Dresen et al.45 | Morphologic + volumetric criteria | 67 | TNM |
| Intven et al.56 | Relative volume | 51 | TRG | |
| Petrillo et al.52 | Score system | 106 | TRG | |
| Petrillo et al.64 | Relative volume | 29 | TRG | |
| Intven et al.56 | Relative Ktrans | 51 | TRG | |
| Kim et al.55 | Relative Ktrans | 50 | TNM | |
| DCE-MRI | Martens et al.67 | TIC slope | 30 | TRG |
| Petrillo et al.52 | TIC visual inspection | 106 | TRG | |
| Petrillo et al.64 | Relative volume | 29 | TRG | |
| Petrillo et al.53 | Standardized index of shape | 74 | TRG | |
| Birlik et al.65 | ADC | 43 | TRG | |
| DWI | Ippolito et al.40 | ADC | 30 | TRG |
| Monguzzi et al.68 | ADC | 31 | TRG | |
| Petrillo et al.64 | Relative volume | 29 | TRG | |
| MULTIMODAL IMAGING | Intven et al.56 | Relative volume + relative Ktrans | 51 | TRG |
| Marouf et al.63 | MRI + DWI Score system | 19 | TNM | |
| Altini et al.36 | SUV | 68 | TRG | |
| Capirci et al.42 | SUV | 81 | TRG | |
| Ippolito et al.40 | SUV | 30 | TRG | |
| PET/CT | Murcia et al.43 | SUV | 41 | TRG |
| Sun et al.41 | Total lesion glycolysis | 35 | TRG | |
| Yoon et al.66 | Dual-point index | 61 | TRG | |
| Palma et al.73 | SUV | 50 | TRG |