IHC IGF1R expression by histological/clinical characteristics and diabetes mellitus
| Variable | IGF1R positive No (%) | IGF1R negative No (%) | P value |
|---|---|---|---|
| All patients | 133 (79.6%) | 34 (20.4%) | |
| Histology | 0.03 | ||
| - NSCC | 78 (74.3%) | 27 (25.7%) | |
| - SCC | 55 (88.7%) | 7 (11.3%) | |
| Sex | 0.17 | ||
| - Male | 98 (82.4%) | 21 (17.6%) | |
| - Female | 35 (72.9%) | 13 (27.1%) | |
| Smoking status | 0.77 | ||
| - Current/former smoker | 116 (80.0%) | 29 (20.0%) | |
| - Never smoker | 17 (77.3%) | 5 (22.7%) | |
| ECOG - PS | 0.97 | ||
| - 0–1 | 121 (79.6%) | 31 (20.4%) | |
| - ≥ 2 | 12 (80.0%) | 3 (20.0%) | |
| Diabetes mellitus type 2 | 0.84 | ||
| - No | 119 (79.9%) | 30 (20.1%) | |
| - Yes | 14 (77.8%) | 4 (22.2%) |
Patient and tumour characteristics
| Variable | No (%) |
|---|---|
| All patients | 167 (100%) |
| Histology | |
| - NSCC | 105 (62.9%) |
| - SCC | 62 (37.1%) |
| Sex | |
| - Male | 119 (71.3%) |
| - Female | 48 (28.7%) |
| Smoking status | |
| - Current/former smoker | 145 (86.8%) |
| - Never smoker | 22 (13.2%) |
| ECOG-PS | |
| - 0-1 | 152 (91.0%) |
| - ≥ 2 | 15 (9.0%) |
| Diabetes mellitus type 2 | |
| - No | 149 (89.2%) |
| - Yes | 18 (10.8%) |
| IGF1R expression | |
| - Positive | 133 (79.6%) |
| - Negative | 34 (20.4%) |
Univariate and multivariate analysis of overall survival
| Variable | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Histology | ||||||
| SCC vs NSCC | 1.097 | 0.798–1.509 | 0.569 | 1.249 | 0.885–1.763 | 0.206 |
| Sex | ||||||
| Male vs female | 1.396 | 0.994–1.961 | 0.054 | 1.390 | 0.939–2.057 | 0.100 |
| Smoking status | ||||||
| Current/former smoker vs. non-smoker | 1.692 | 1.064–2.689 | 0.026 | 1.509 | 0.908–2.510 | 0.113 |
| ECOG-PS | ||||||
| 0.1 vs ≥ 2 | 0.600 | 0.351–1.025 | 0.061 | 0.589 | 0.341–1.015 | 0.057 |
| Diabetes mellitus type 2 | ||||||
| Yes vs No | 0.869 | 0.531–1.423 | 0.576 | 0.828 | 0.498–1.378 | 0.468 |
| IGF1R | ||||||
| Positive vs negative | 0.766 | 0.523–1.121 | 0.170 | 0.776 | 0.518–1.162 | 0.219 |