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Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder Cover

Comparison between cryoablation and irreversible electroporation of rabbit livers at a location close to the gallbladder

Open Access
|Jan 2016

Figures & Tables

Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.
Photos of the liver and gallbladder bef ore cryoablation. (A) Cryoprobe insertion. (B) Ice ball formation. Th e white arrows in (A and B) indicate the gallbladder. The black arrow in (A) indicates the cryoprobe.
Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.
Photos of the liver and gallbladder before IRE ablation. (A) Electrode placement. (B) Immediately after the probes are pulled out, the gallbladder and liver do not show any significant changes. The white arrows in (A and B) indicate the gallbladder. The black arrows in (A) indicate the IRE probes. The blue arrows in (B) indicate the insertion sites of the two monopolar IRE probes.
Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.
Distance between two monopolar IRE probes. The two probes are 1.5 cm apart.
Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after cryoablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Photos of the liver and gallbladder after IRE ablation. The liver as viewed from the (A) gallbladder and (B) diaphragmatic side 7 days after the ablation.
Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).
Pathological changes in the cryoablation (Cryo) and IRE ablation zones 7 days after ablation. (A) The top images show the ablated liver and gallbladder areas (magnification, 40×). The bottom images (A to E) show enlarged versions of the areas marked in the top images (magnification, 400×). (B) The top images and (F) show the ablated liver, gallbladder and common bile duct (magnification, 40×). The bottom images (A to D) show the enlarged versions of the areas marked in the top images (magnification, 400×).

Sizes of liver and gallbladder lesions at 7 days after the ablation (X̅± s)

AblationMajor diameter of liver lesions (cm)Gallbladder lesions
methodsGallbladder side (n = 12)Diaphragm side (n = 12)P valueMajor diameter (cm)P value
Cryo1.5 ± 0.43.8 ± 0.8> 0.051.5 ± 0.4 (n = 8)> 0.05
IRE1.4 ± 0.44.1 ± 0.7> 0.050.8 ± 0.2 (n = 12)

Changes in aminotransferase and serum bilirubin levels over time (X̅± s)

Hepatic functionAblation methodd-1d-1d-3d-5d-7
ALT(U/L)RE38.35 ± 3.22167.05 ± 19.50214.83 ± 10.37119.60 ± 12.9968.25 ± 10.08
Cryo39.20 ± 3.90195.03 ± 9.75

P < 0.01, compared with the IRE group

289.58 ± 12.81

P < 0.01, compared with the IRE group

142.35 ± 57.85

P < 0.05

94.90 ± 9.78

P < 0.05

AST(U/L)IRE34.10 ± 0.8647.64 ± 0.6960.21 ± 2.5546.78 ± 1.7131.05 ± 0.43
Cryo35.26 ± 2.4560.11 ± 3.44

P < 0.01, compared with the IRE group

79.12 ± 2.58

P < 0.01, compared with the IRE group

52.80 ± 3.41

P < 0.05

37.41 ± 2.50

P < 0.05

Serum bilirubin(μmol/L)RE8.08 ± 2.1926.01 ± 3.6835.15 ± 5.7029.09 ± 3.2721.41 ± 3.39
Cryo7.59 ± 2.0132.72 ± 4.08

P < 0.01, compared with the IRE group

37.34 ± 6.14

P < 0.05

35.88 ± 4.28

P < 0.01, compared with the IRE group

25.86 ± 5.37

P < 0.05

DOI: https://doi.org/10.1515/raon-2017-0003 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 40 - 46
Submitted on: Aug 26, 2016
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Accepted on: Nov 19, 2016
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Published on: Jan 14, 2016
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2016 Jianying Zeng, Zilin Qin, Liang Zhou, Gang Fang, Jibing Chen, Jialiang Li, Lizhi Niu, Bing Liang, Kecheng Xu, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.