Table 1
The characteristics of patients and surgical outcomes
| Primary surgery N = 80 | NACT N = 80 | p | |
|---|---|---|---|
| Age (years) | 60.2 | 64.8 | 0.006 |
| High grade serous | 43 (54%) | 53 (66%) | 0.307 |
| Performance 0 or 1 | 66 (83%) | 32 (40%) | < 0.0001 |
| >1 | 14 (17%) | 48 (60%) | |
| R0 resection | 16 (20%) | 34 (42%) | 0.011 |
| R1 resection | 18 (23%) | 18 (22%) | 1.0 |
| R2 resection | 46 (57%) | 11 (14%) | < 0.0001 |
| Inoperable | - | 17 (21%) | - |
| PFS (months) | 17.7 | 14.1 | 0.213 |
| OS (months) | 31.6 | 24.8 | 0.012 |
NACT = neoadjuvant chemotherapy; OS = overall survival; PFS = progression-free survival; R0 = no macroscopic residual disease; R1= < 1 cm residual disease; R2= >1 cm residual disease
Figure 1
Progression free survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).
Figure 2
Overall survival of patients after primary surgery and neoadjuvant chemotherapy (NACT).
Figure 3
Survival curves of patients after different surgical outcomes.
NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= < 1 cm residual disease; R2= >1 cm residual disease
Table 2
Five-year and eight-year survival of patients after different surgical outcomes
| Five-year survival | Eight year survival | p | |
|---|---|---|---|
| Surgery - R0 resection | 62.5% | 62.5% | P < 0.0001 |
| NACT -R0 resection | 20.6% | 17.1% | |
| Surgery - R1 resection | 38.9% | 27.8% | P < 0.0001 |
| NACT -R1 resection | 16.7% | 11.1% | |
| Surgery - R2 resection | 15.5% | 0% | P < 0.0001 |
| NACT -R2 resection | 0% | 0% | |
| Inoperable disease | 0% | 0% | - |
NACT = neoadjuvant chemotherapy; R0 = no macroscopic residual disease; R1= < 1 cm residual disease; R2= >1 cm residual disease