Figure 1
Figure 2
Impact of the eleven factors on local control of SCC (univariate analysis)
| At 1 year(%) | At 2 years(%) | At 3 years(%) | p-value | |
|---|---|---|---|---|
| Age | ||||
| ≤ 64 years (n = 125) | 94 | 86 | 86 | |
| ≥ 65 years (n = 113) | 92 | 75 | 75 | 0.81 |
| Gender | ||||
| Female (n = 88) | 90 | 78 | 78 | |
| Male (n = 150) | 94 | 85 | 85 | 0.47 |
| Myeloma subtype | ||||
| IgG subtype (n = 153) | 96 | 84 | 84 | |
| Other subtypes (n = 85) | 88 | 78 | 78 | 0.14 |
| Time from myeloma diagnosis to SCC | ||||
| ≤ 15 months (n = 128) | 95 | 81 | 81 | |
| > 15 months (n = 110) | 91 | 85 | 85 | 0.83 |
| Extra-osseous lesions | ||||
| No (n = 218) | 94 | 82 | 82 | |
| Yes (n = 20) | 67 | n.a. | n.a. | 0.19 |
| Further osseous lesions | ||||
| No (n = 91) | 93 | 86 | 86 | |
| Yes (n = 147) | 93 | 76 | 76 | 0.73 |
| Time developing motor deficits | ||||
| Faster (≤ 14 days) (n = 112) | 93 | 81 | 81 | |
| Slower (> 14 days = (n = 126) | 93 | 83 | 83 | 0.79 |
| Gait function before the start of RT | ||||
| Ambulatory (n = 169) | 95 | 85 | 85 | |
| Not ambulatory (n = 69) | 85 | 57 | 57 | 0.08 |
| Number of vertebrae involved by SCC | ||||
| 1-2 (n = 112) | 95 | 87 | 87 | |
| ≤ 3 (n = 126) | 92 | 77 | 77 | 0.17 |
| ECOG performance score | ||||
| 1-2 (n = 150) | 96 | 86 | 86 | |
| 3-4 (n = 88) | 83 | 62 | 62 | 0.07 |
| Radiotherapy regimen | ||||
| Short-course RT (n = 84) | 94 | 69 | 69 | |
| Longer-course RT (n = 154) | 93 | 90 | 90 | 0.29 |
| Entire cohort (n = 238) | 93 | 82 | 82 | |