Table 1
Risk for coronary artery disease in testicular cancer survivors regarding to different treatment modalities
| Author (year) | N | Period of treatment | Median follow up (range), in years | Age at diagnosis (range) | Age at follow-up (range) | Risk for CAD (CI 95 %) | Treatment Modalities | Note |
|---|---|---|---|---|---|---|---|---|
| Meinardi et al.17 (2000) | 87 | Before 1987a | 14 (10 to 20) | 27 (17-36) | 42 (30-50) | SIR=7.1 (1.9 to 18.3) | ChT | Age adjusted results. Older than 50 years at follow-up were excluded |
| Huddart et al.24 (2003) | 992 | 1982-1992 | 10.2 (0 to 20.3) | 31.7 (10-82) | 44 (23-78) | RR=1.00 (reference) RR=2.59 (1.15 to 5.84) RR=2.40 (1.04 to 5.45) RR=2.78 (1.09 to 7.07) | Surveillance ChT ChT RT ChT and RT | Age adjusted results. Only 8.3 % of RT treated patients had also med. RT |
| Van der Belt- Dusebuot et al.11 (2006) | 2339 | 1965-1995 | 18.4 (5 to 38.4) | 38.3b (n.r.) 28.1c (n.r.) | 59.8b (n.r.) 50.4c (n.r.) | SIR=0.94 (0.61 to 1.39) SIR=1.35 (0.97 to 1.83) SIR=1.07 (0.92 to 1.23) SIR=2.48 (1.77 to 3.37) SIR=0.92 (0.77 to 1.08) SIR=2.97 (1.73 to 4.77) SIR=1.83 (1.08 to 2.90) | Surveillance ChT RT RT – med RT – subdia RT – med. + ChT RT – subdia. + ChT | Patients with CAD before or within 5 years from diagnosis were excluded |
| Haughnes et al.12 (2010) | 990 | 1980-1994 | 19 (13 to 28) | 31 (15-53) | 51 (31-69) | HR=1.0 (reference) HR=2.0 (0.64 to 6.1) HR=5.7 (1.9 to 17.1) HR=2.1 (0.78 to 5.4) HR=5.3 (1.5 to 18.3) | Surveillance ChT (CVB) ChT (BEP) RT ChT + RT | Age adjusted results. Patients with CAD before or within 2 years from diagnosis were excluded. Only 3 of 420 RT treated patients had also med. RT |
BEP = bleomycin, etoposid, cisplatin; CAD = coronary artery disease; ChT = chemotherapy; CVB = cisplatin, etoposid, bleomycin; HR = hazard ratio; med. = mediastinal; N = number of patients; n.r. = not reported; RT =radiotherapy; RR = relative risk; SIR = standardized incidence ratio; subdia. = subdiaphragmatic;