Table 1.
List of group 1 patients treated using combined systemic and local bleomycin administration in the second treatment session
| Patient | Breed | Location of the tumor | Weight (kg) | Histology | Stage | Size (cm3) | Response 1 (ECT) | Response 2 (S+L) |
|---|---|---|---|---|---|---|---|---|
| 1 | Labrador retriever | Oral | 32 | Mastocytoma | II | 10.6 | PR | CR |
| 2 | Cross-breed | Oral | 21 | Squamous cell carcinoma | II | 36.2 | SD | PR |
| 3 | Labrador retriever | Nasal | 32 | Squamous cell carcinoma | II | 43.5 | PR | CR |
| 4 | Yorkshire | Perianal | 5 | Solid differentiated carcinoma | IV | 173.8 | SD | SD |
| 5 | Cross-breed | Elbow | 12 | Schwannoma | I | 67.6 | SD | PR |
| 6 | Rottweiler | Oral | 37 | Fibrosarcoma | I | 109.5 | SD | CR |
| 7 | Labrador retriever | Nasal | 38 | Squamous cell carcinoma | III | 42.4 | SD | PR |
| 8 | Boxer | Oral | 37 | Fibrosarcoma | III | 112.2 | SD | PR |
| 9 | Cocker spaniel | Oral | 15 | Melanoma | II | 8.7 | PR | CR |
| 10 | Beagle | Oral | 16 | Melanoma | III | 12.4 | PR | CR |
| 11 | Cocker spaniel | Oral | 16 | Melanoma | III | 26.64 | PR | CR |
CR = complete response; ECT = electrochemotherapy; PR = partial response; SD = stable disease; S+L = systemic + local
Table 2.
List of group 2 patients (control) treated using a repetition of the first session
| Patient | Breed | Location of the tumor | Weight (kg) | Histology | Stage | Size (cm3) | Response 1 (ECT) | Response 2 (ECT) |
|---|---|---|---|---|---|---|---|---|
| 12 | Cross-breed | Oral | 30 | Melanoma | I | 158.2 | PR | SD |
| 13 | Cross-breed | Oral | 21 | Sarcoma | III | 79.76 | PR | SD |
| 14 | Cross-breed | Oral | 20 | Carcinoma | III | 96.5 | PR | SD |
| 15 | Toy Poodle | Oral | 5 | Fibrosarcoma | II | 23.23 | PD | PD |
| 16 | Cross-breed | Oral | 11 | Melanoma | II | 73.8 | PR | SD |
| 17 | Cross-breed | Oral | 16 | Schwannoma | II | 467.02 | PD | SD |
| 18 | Cross-breed | Oral | 6 | Squamous cell carcinoma | II | 12.32 | SD | SD |
| 19 | Labrador retriever | Oral | 32 | Fibrosarcoma | II | 40 | PR | SD |
| 20 | Rottweiler | Oral | 34 | Melanoma | II | 33 | PR | PR |
| 21 | German Shepherd | Oral | 39 | Fibrosarcoma | II | 101.18 | PR | PD |
| 22 | Cross-breed | Oral | 14 | Melanoma | II | 14.4 | PR | PR |
CR = complete response; ECT = electrochemotherapy; PD = progressive disease; PR = partial response; SD = stable disease; S+L = systemic + local
Figure 1.
Case number 6. (A) before combined treatment, a fibrosarcoma which failed to respond to the first ECT treatment. (B) CR was obtained after combined treatment.
Figure 2.
Graph shows the objective response rate obtained in the second session, in a comparison between combined bleomycin administration, both systemic and local (S+L), and systemic alone (S Alone).
ECT = electrochemotherapy