Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor

Smrdel, Uros; Popovic, Mara; Zwitter, Matjaz; Bostjancic, Emanuela; Zupan, Andrej; Kovac, Viljem; Glavac, Damjan; Bokal, Drago; Jerebic, Janja

Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor

Volume 50 (2016): Issue 4 (December 2016)

By:

Uros Smrdel, Mara Popovic, Matjaz Zwitter, Emanuela Bostjancic, Andrej Zupan, Viljem Kovac, Damjan Glavac, Drago Bokal and Janja Jerebic

Open Access

|Nov 2016

Figures & Tables

Methyl guanine methyl transferase (MGMT) promoter methylation in long term survivors and control group.

Izocitratedehidrogenaze1 (IDH1) mutations in long term survivors and control group.

Demographics, standard prognostic factors and treatment for long-term survivor (LTS) group and control group

Variable		LTS group	Control group
Mean age (range)		47,5 (21–74)	49, 6 (23–74)
Gender	Male	24	31
	Female	16	9
Surgery	Gross total	22	23
	Reduction	15	15
	Biopsy	3	2
WHO PS	0	9	5
	1	25	26
	2	4	9
	3	2	0
Mean RT dose (Gy)		58	57,9
RT technique	1D	1	0
	2D	3	3
	3D	36	37
No. of fractions		25–33	25–33
Chemotherapy	Yes	37	39
	Adjuvant only	3	1

Molecular and genetic markers

	LTS group	Control group	P value
IDH1(immunohistochemistry)	6/40	1/34	0.043
IDH1 (genetic)	6/38	1/33	0.043
IDH2 (genetic)	0/38	0/33	n.s.
1p/19q	0/38	1/34	n.s.
1p	3/38	1/34	n.s.
19q	10/38	6/34	n.s.
MGMT methylation	36/38	12/33	< 0.001
CDKN2A (deletion)	29/39	25/34	n.s.
CDKN2B (deletion)	27/39	24/34	n.s.

Response to primary treatment

	LTS group	Control group	P value
Complete response * Includes patients reported by surgeon as gross total resection; LTS = long term survivor	24	4	< 0.001
Partial response	5	2	n.s.
Stable disease	4	13	0.013
Progression	7	20	0.002
Overall response	31/40	19/40	< 0.001
Non evaluable	0	1

DOI: https://doi.org/10.1515/raon-2015-0041 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 394 - 401

Submitted on: Jul 15, 2015

Accepted on: Aug 6, 2015

Published on: Nov 10, 2016

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 times per year

Keywords:

glioblastoma,

long-term survival,

methyl guanine methyl transferase,

Related subjects:

Haematology, oncology,

Radiology

© 2016 Uros Smrdel, Mara Popovic, Matjaz Zwitter, Emanuela Bostjancic, Andrej Zupan, Viljem Kovac, Damjan Glavac, Drago Bokal, Janja Jerebic, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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