Influence of selected polymorphisms on the risk for secondary thyroid cancer
| SNP | OR (95% CI) | p |
|---|---|---|
| GPX1 (rs1050450) | 0.43 (0.07-1.88) | 0.344 |
| SOD2 data missing for 2 controls | 1.50 (0.36-7.23) | 0.754 |
| CAT (rs 1001179) | 1.00 (0.27-3.74) | 1.000 |
| GSTP1 (rs1695) | 1.40 (0.38-5.59) | 0.774 |
| GSTP1 (rs 1138272) | 1.25 (0.27-6.30) | 1.000 |
| GSTM1 (gene deletion) data missing for 1 control | 0.43 (0.07-1.88) | 0.344 |
| GSTT1 (gene deletion) data missing for 1 control | 2.00 (0.29-22.11) | 0.687 |
Genotype frequencies of the antioxidant defence-related genes
| SNP | Genotype | All patients N (%) | Cases N (%) | Controls N (%) | PHWE controls |
|---|---|---|---|---|---|
| GPX1 rs1050450 p. Pro200Leu | CC | 28 (58.3) | 16 (66.7) | 12 (50) | 0.967 |
| CT | 17 (35.4) | 7 (29.2) | 10 (41.7) | ||
| TT | 3 (6.3) | 1 (4.2) | 2 (8.3) | ||
| SOD2 data missing for 2 controls | GG | 10 (21.7) | 4 (16.7) | 6 (27.3) | 0.338 |
| GA | 31 (67.4) | 18 (75) | 13 (59.1) | ||
| AA | 5 (10.9) | 2 (8.3) | 3 (13.6) | ||
| CAT rs1001179 c.-262G>A | GG | 32 (66.7) | 16 (66.7) | 16 (66.7) | 0.834 |
| GA | 14 (29.2) | 7 (29.2) | 7 (29.2) | ||
| AA | 2 (4.2) | 1 (4.2) | 1 (4.2) | ||
| GSTP1 rs1695 p.Ile105Val | AA | 22 (45.8) | 10 (41.7) | 12 (50) | 0.432 |
| AG | 23 (47.9) | 12 (50) | 11 (45.8) | ||
| GG | 3 (6.3) | 2 (8.3) | 1 (4.2) | ||
| GSTP1 rs1138272 p.Ala114Val | CC | 39 (81.3) | 19 (79.2) | 20 (83.3) | 0.106 |
| CT | 8 (16.7) | 5 (20.8) | 3 (12.5) | ||
| TT | 1 (2.1) | / | 1 (4.2) | ||
| GSTM1 b gene deletiondata missing for 1 control | non-null | 23 (48.9) | 14 (58.3) | 9 (39.1) | |
| null | 24 (51.1) | 10 (41.7) | 14 (60.9) | ||
| GSTT1 b gene deletiondata missing for 1 control | non-null | 39 (83) | 19 (79.2) | 20 (87) | |
| null | 8 (17) | 5 (20.8) | 3 (13) |