Antioxidant defence-related genetic variants are not associated with higher risk of secondary thyroid cancer after treatment of malignancy in childhood or adolescence

SNP	Genotype	All patients N (%)	Cases N (%)	Controls N (%)	P_HWE controls
GPX1 rs1050450 p. Pro200Leu	CC	28 (58.3)	16 (66.7)	12 (50)	0.967
	CT	17 (35.4)	7 (29.2)	10 (41.7)
	TT	3 (6.3)	1 (4.2)	2 (8.3)
SOD2a rs4880 p.Val16Ala	GG	10 (21.7)	4 (16.7)	6 (27.3)	0.338
	GA	31 (67.4)	18 (75)	13 (59.1)
	AA	5 (10.9)	2 (8.3)	3 (13.6)
CAT rs1001179 c.-262G>A	GG	32 (66.7)	16 (66.7)	16 (66.7)	0.834
	GA	14 (29.2)	7 (29.2)	7 (29.2)
	AA	2 (4.2)	1 (4.2)	1 (4.2)
GSTP1 rs1695 p.Ile105Val	AA	22 (45.8)	10 (41.7)	12 (50)	0.432
	AG	23 (47.9)	12 (50)	11 (45.8)
	GG	3 (6.3)	2 (8.3)	1 (4.2)
GSTP1 rs1138272 p.Ala114Val	CC	39 (81.3)	19 (79.2)	20 (83.3)	0.106
	CT	8 (16.7)	5 (20.8)	3 (12.5)
	TT	1 (2.1)	/	1 (4.2)
GSTM1bb gene deletion	non-null	23 (48.9)	14 (58.3)	9 (39.1)
GSTM1bb gene deletion	null	24 (51.1)	10 (41.7)	14 (60.9)
GSTT1bb gene deletion	non-null	39 (83)	19 (79.2)	20 (87)
GSTT1bb gene deletion	null	8 (17)	5 (20.8)	3 (13)

CAT = catalase

GPX = glutathione peroxidase

GSTM1 = glutathione S-transferase Mu 1

GSTP1= glutathione S-transferase pi gene

GSTT1 = glutathione S-transferase theta 1

HWE= Hardy-Weinberg equilibrium

N = number

SNP = single nucleotide polymorphism

SOD2 = manganese superoxide dismutase

a data missing for 2 controls

bb data missing for 1 control

Table 2

Influence of selected polymorphisms on the risk for secondary thyroid cancer

SNP	OR (95% CI)	p
GPX1 (rs1050450)	0.43 (0.07-1.88)	0.344
SOD2a (rs4880)	1.50 (0.36-7.23)	0.754
CAT (rs 1001179)	1.00 (0.27-3.74)	1.000
GSTP1 (rs1695)	1.40 (0.38-5.59)	0.774
GSTP1 (rs 1138272)	1.25 (0.27-6.30)	1.000
GSTM1 (gene deletion)b	0.43 (0.07-1.88)	0.344
GSTT1 (gene deletion)b	2.00 (0.29-22.11)	0.687

CAT = catalase

CI = confident interval

GPX = glutathione peroxidase

GSTM1 = glutathione S-transferase Mu 1

GSTP1= glutathione S-transferase pi gene

GSTT1 = glutathione S-transferase theta 1

OR = odd ratio

SNP = single nucleotide polymorphism

SOD2 = manganese superoxide dismutase

a data missing for 2 controls

b data missing for 1 control

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DOI: https://doi.org/10.1515/raon-2015-0026 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 80 - 86

Submitted on: Feb 2, 2015

Accepted on: Feb 23, 2015

Published on: Feb 16, 2016

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

secondary thyroid cancer,

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© 2016 Ana Lina Vodusek, Katja Goricar, Barbara Gazic, Vita Dolzan, Janez Jazbec, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 50 (2016): Issue 1 (March 2016)