Median survival rates of patients with T1 to T4 N0 tumours according to their positive and negative Ca19-9 serum levels around the cut-off of 3_5 IU/ml
| Tumour stage | Ca19-9 cut-off | Median survival (months ± SD |
|---|---|---|
| T1N0 | Negative | 121 ± 15.7 |
| Positive | 126 ± 12.2 | |
| T2N0 | Negative | 121 ± 13.9 |
| Positive | 89 ± 13.1 | |
| T3N0 | Negative | 103 ± 18 |
| Positive | 65 ± 12.4 | |
| T4N0 | Negative | 47 ± 18.9 |
| Positive | 18 ± 2.2 |
Patient demographic and tumor characteristics according to their positive and negative Ca19-9 serum levels around the cut-off of 3_5 IU/ml
| Characteristic | Ca19-9 negative | Ca19-9 positive |
|---|---|---|
| Gender [male (%)] | 63 | 57 |
| Age (years ± SD) | 64 ± 12.2 | 64 ± 11.9 |
| ASA (%) | ||
| I | 41.8 | 37.1 |
| II | 37.3 | 37.1 |
| III | 20.9 | 25.7 |
| Lymphadenectomy (%) | ||
| D1 | 19.2 | 23.9 |
| D2 | 80.8 | 76.1 |
| Tumou r site (%) | ||
| Lesser curvature | 33.3 | 38.6 |
| Greater curvature | 38.9 | 40.4 |
| Anterior wall | 25.0 | 15.8 |
| Posterior wall | 1.4 | 2.6 |
| Circumferential | 1.4 | 2.6 |
| Differentiation (%) | ||
| Well | 27.4 | 21.0 |
| Moderate | 25.8 | 33.0 |
| Poor | 46.8 | 46.0 |
| Lauren (%) | ||
| Intestinal | 63.9 | 47.2 |
| Diffuse | 19.7 | 31.5 |
| Mixed | 16.4 | 21.3 |
| Lymphangial invasion [yes (%)] | 52.9 | 54.7 |
| Vascular invasion[yes (%)] | 7.3 | 11.1 |
| Perineural invasion[yes (%)] | 15.7 | 14.4 |
| T stage (%) | ||
| 1 | 31.5 | 43.8 |
| 2 | 38.4 | 28.9 |
| 3 | 26.0 | 18.4 |
| 4 | 4.1 | 8.8 |
| UICC (%) | ||
| Ia | 31.5 | 45.6 |
| Ib | 38.4 | 28.9 |
| IIa | 26.0 | 16.7 |
| IIb | 1.4 | 5.3 |
| IIIb | 2.7 | 3.5 |
| Tumour diameter (mm ± SD) | 52 ± 33.8 | 50 ± 32.4 |
| Number of extractedlymph nodes (n ± SD) | 21 ± 11.2 | 20 ± 10.7 |
Results of the multivariate regression model analysis
| Factor | Hazard ratio | 95% confidence interval | p | |
|---|---|---|---|---|
| Lower | Upper | |||
| Perineural invasion | 1.337 | 0.612 | 2.921 | NS |
| Tumour site | 1.151 | 0.881 | 1.502 | NS |
| T stage | 1.755 | 1.321 | 2.330 | < 0.0001 |
| Extracted lymph nodes | 0.972 | 0.948 | 0.997 | 0.026 |
| Preoperative Ca19-9 serum level | 1 | 1.000 | 1.001 | NS |
| Ca19-9 cut-off (3.5 IU/ml) | 1.045 | 0.528 | 2.068 | NS |