Experimental Research Into the Effect of Hyperbaric Exposures

Dolatkowski, Augustyn; Doboszyński, Tadeusz; Łokucijewski, Bogdan

doi:10.1515/phr-2017-0021

Abstract

Numerous research works indicate that staying in a hyperbaric environment is a stressor. We have undertaken studies using an animal model to determine the effect of hyperbaria on adrenocortical secretion and the level of adrenal ascorbic acid (a.a.a.). The research was conducted on 70 male hooded rats, which were divided into groups and subjected to hyperbaric air and oxygen at an overpressure of 1 and 3 atn, with some of the animals being additionally burdened with physical effort (swimming). It was found that short-term exposures (30 minutes) of rats to hyperbaric conditions caused a decrease in the content of a.a.a. With a prolonged (3-hour) exposure to 3 atm air the a.a.a. content returns to a normal level. A reduction in the a.a.a. content indicates the presence of stress in hyperbaric conditions in the rat, however, it does not allow to determine its intensity with the method used in the study.

References

1. Aschan G.: "Oxygen deficiency and oxygen poisoning as stress factors". Acta Soc.Med.Upsal.58, 265-268, 1953;
Search in Google Scholar Back to article
2. Bagramian E.R.: "O wlijanii narkoza na reakciju gipofizo-nadpoczecznikowoj sistiemy na naprjażenijo", Farmakoł. Toksikoł., 27, 335-338, 1964.
Search in Google Scholar Back to article
3. Bean J.W., Johnson P.C.: Am.J.Physiol., 179, 410-414, 1954;10.1152/ajplegacy.1954.179.3.410
Search in Google Scholar Back to article
4. Bean J.W.: "Tris buffer, CO2 and sympatho-adrenal system in reactions to O2 at high pressure", Am.J.Physiol.,201, 737-739, 1961;10.1152/ajplegacy.1961.201.4.737
Search in Google Scholar Back to article
5. Boulouard R.: "Effects of cold and starvation on adrenocartical activity of rats", Fed.Proc., 22, 750-754, 1963;
Search in Google Scholar Back to article
6. Charvat J.: "Steroid hormones", PZWL, Warsaw 1953;
Search in Google Scholar Back to article
7. Doboszyński T., Łokucijewski B.: Biul. Inst. Med. Mor., 17, 311-320, 1966;
Search in Google Scholar Back to article
8. Doboszyński T., Łokucijewski B.: "Ekspierymentalnoje issledowania wlijanija wysokogo dawlenia kisłoroda". II Międzynarodowe Sympozjum Medycyny Morskiej, Gdynia 1965;
Search in Google Scholar Back to article
9. Fenn W.O.: "Psychological effects of high pressures of nitrogen and oxygen", Circulation, 26, 1134-1143, 1962;10.1161/01.CIR.26.5.1134
Open DOI Search in Google Scholar Back to article
10. Gerschman R., Fenn W.O.: "Ascorbic acid content of adrenal inoxygen poisoning", Am.J.Physiol., 171, 726, 1952;
Search in Google Scholar Back to article
11. Gerschman R., Fenn W.O.: "Ascorbic acid content of adrenal inoxygen poisoning", Am.J.Physiol., 176, 6-8, 1954;10.1152/ajplegacy.1953.176.1.6
Search in Google Scholar Back to article
12. Jamieson D., Brenk H.A.S.:"The effects of antioxidants at high pressure oxygen toxicity", Biochem. Pharmacol., 13, 159-164, 1964;10.1016/0006-2952(64)90133-9
Open DOI Search in Google Scholar Back to article
13. Kołpakow M.G.: Nadpoczeczniki i reanimacija, Medicina, Moscow 1964;
Search in Google Scholar Back to article
14. Łokucijewski B., Doboszyński T.: "The effect of hyperbaric oxygenation on ascorbic acid content in the adrenal glands of rats", Med.Pracy, 18, 484-8, 1967;
Search in Google Scholar Back to article
15. Namysłowski L.: "The results of further observations on the behaviour of ascorbic acid in adrenal glands of rats under the influence of physical effort", Roczn. PZH, 8, 79-80, 1957;
Search in Google Scholar Back to article
16. Namysłowski L.: "The effect of physical effort on ascorbic acid content in adrenal glands of rats”, Roczn. PZH, 7, 425-433, 1956;
Search in Google Scholar Back to article
17. Pankow J.A.: "Niekotoryje dannyje ob. Imienienii funkcji kory nad pocecznikow u żywotnych w processie razwitja sostojanija naprażenja (stress)", Probl.Endokrin.Gormonoter., 9, 6, 3-6, 1963;
Search in Google Scholar Back to article
18. Pare W.P.:"The effect of chronic environmental stress on stomach ulceration, adrenal function and consummatory behaviour in the rat", J.Psychol., 57, 143-151, 1964;10.1080/00223980.1964.991668314100114
Search in Google Scholar Back to article
19. Ryłowa M.Ł.: Mietody issledowanija chroniczeskiego dejstwia wrednych faktorow sredy w eksperimentie, Medicina, Leningrad, 1964;
Search in Google Scholar Back to article
20. Sayers G., Sayers M., Lewis H.L., Long C.N.H.: "Effect of adrenotropi hormone on ascorbic acid and cholesterol content of the adrenal", Proc. Soc. Exp. Biol. Med., 55, 238-239, 1944;10.3181/00379727-55-14537P
Open DOI Search in Google Scholar Back to article
21. Sayers G., Sayers M.: "Regulation of pituitary adrenocorticotropin activity during the response of the rat to acute stress", Endocrinology, 40, 265-273, 194710.1210/endo-40-4-26520296119
Open DOI Search in Google Scholar Back to article

Experimental Research Into the Effect of Hyperbaric Exposures

Abstract

Paradigm

My account